HLA-B44
 | ||
| HLA-B (alpha)-β2MG with bound peptide | ||
| major histocompatibility complex (human), class I, B44 | ||
| Alleles | B*4401, 4402, 4403 . . | |
| Structure (See HLA-B) | ||
| Shared data | ||
| Locus | chr.6 6p21.31 | |
HLA-B44 (B44) is an HLA-B serotype. The serotype identifies the B*44 gene-allele protein products of HLA-B.[1]
Further information: HLA-serotype tutorial
B44 is a split antigen of the broad antigen B12, and is a sister type of B45.
Serotype
| B*44 | B44 | B12 | B45 | Sample |
| allele | % | % | % | size (N) |
| *4402 | 98 | 6959 | ||
| *4403 | 94 | 2854 | ||
| *4404 | 65 | 42 | ||
| *4405 | 92 | 130 | ||
| *4406 | 44 | 9 | ||
| B*4401 was shown to be B*4402 after errors corrected. | ||||
| Alleles link-out to IMGT/HLA Database at EBI | ||||
Disease
HLA-B44 increases recurrent sinopulmonary infections.[3] Protective effects: HLA-B44 appears to be protective against autoimmune lymphoproliferative syndrome in patients with C95 defect (ALPS type Ia).[4] B44 may be a cofactor in ankylosing spondylitis[5]
References
- ↑ Marsh SG, Albert ED, Bodmer WF et al. (2005). "Nomenclature for factors of the HLA system, 2004". Tissue Antigens 65 (4): 301–69. doi:10.1111/j.1399-0039.2005.00379.x. PMID 15787720.
- ↑ derived from IMGT/HLA
- ↑ Johnston DT, Mehaffey G, Thomas J et al. (June 2006). "Increased frequency of HLA-B44 in recurrent sinopulmonary infections (RESPI)". Clin. Immunol. 119 (3): 346–50. doi:10.1016/j.clim.2006.02.001. PMID 16542878.
- ↑ Vacek MM, Schäffer AA, Davis J et al. (January 2006). "HLA B44 is associated with decreased severity of autoimmune lymphoproliferative syndrome in patients with CD95 defects (ALPS type Ia)". Clin. Immunol. 118 (1): 59–65. doi:10.1016/j.clim.2005.09.006. PMID 16257267.
- ↑ Purrmann J, Zeidler H, Bertrams J et al. (November 1988). "HLA antigens in ankylosing spondylitis associated with Crohn's disease. Increased frequency of the HLA phenotype B27,B44". J. Rheumatol. 15 (11): 1658–61. PMID 3266250.