HIPK2

Homeodomain interacting protein kinase 2
Identifiers
SymbolsHIPK2 ; PRO0593
External IDsOMIM: 606868 HomoloGene: 68766 IUPHAR: 2034 ChEMBL: 4576 GeneCards: HIPK2 Gene
EC number2.7.11.1
Orthologs
SpeciesHumanMouse
Entrez2899615258
EnsemblENSG00000064393ENSMUSG00000061436
UniProtQ9H2X6Q9QZR5
RefSeq (mRNA)NM_001113239NM_001136065
RefSeq (protein)NP_001106710NP_001129537
Location (UCSC)Chr 7:
139.25 – 139.48 Mb		Chr 6:
38.69 – 38.88 Mb
PubMed search

Homeodomain-interacting protein kinase 2 is an enzyme that in humans is encoded by the HIPK2 gene.[1]

HIPK2 is a conserved serine/threonine nuclear kinase that interacts with homeodomain transcription factors.[supplied by OMIM][2]

Interactions

HIPK2 has been shown to interact with SKI protein,[3] Death associated protein 6,[4] P53,[5][6][7] CREB binding protein,[6] Mothers against decapentaplegic homolog 1,[3] TP53INP1[8] and RANBP9.[9]

References

  1. ↑ Wang Y, Hofmann TG, Runkel L, Haaf T, Schaller H, Debatin K, Hug H (Mar 2001). "Isolation and characterization of cDNAs for the protein kinase HIPK2". Biochim Biophys Acta 1518 (1–2): 168–72. doi:10.1016/S0167-4781(00)00308-0. PMID 11267674.
  2. ↑ "Entrez Gene: HIPK2 homeodomain interacting protein kinase 2".
  3. ↑ 3.0 3.1 Harada, Jun; Kokura Kenji, Kanei-Ishii Chie, Nomura Teruaki, Khan Md Matiullah, Kim Yongsok, Ishii Shunsuke (Oct 2003). "Requirement of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activation". J. Biol. Chem. (United States) 278 (40): 38998–9005. doi:10.1074/jbc.M307112200. ISSN 0021-9258. PMID 12874272.
  4. ↑ Hofmann, Thomas G; Stollberg Nicole; Schmitz M Lienhard; Will Hans (Dec 2003). "HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in human hepatoma cells". Cancer Res. (United States) 63 (23): 8271–7. ISSN 0008-5472. PMID 14678985.
  5. ↑ Wang Y, Debatin KM, Hug H (Aug 2001). "HIPK2 overexpression leads to stabilization of p53 protein and increased p53 transcriptional activity by decreasing Mdm2 protein levels". BMC Mol Biol. 2: 8. doi:10.1186/1471-2199-2-8. PMC 48146. PMID 11532197.
  6. ↑ 6.0 6.1 Hofmann, Thomas G; Möller Andreas; Sirma Hüaeyin; Zentgraf Hanswalter; Taya Yoichi; Dröge Wulf; Will Hans; Schmitz M Lienhard (Jan 2002). "Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2". Nat. Cell Biol. (England) 4 (1): 1–10. doi:10.1038/ncb715. ISSN 1465-7392. PMID 11740489.
  7. ↑ Kim, Eun-Joo; Park Jong-Sup; Um Soo-Jong (Aug 2002). "Identification and characterization of HIPK2 interacting with p73 and modulating functions of the p53 family in vivo". J. Biol. Chem. (United States) 277 (35): 32020–8. doi:10.1074/jbc.M200153200. ISSN 0021-9258. PMID 11925430.
  8. ↑ Tomasini, Richard; Samir Amina Azizi; Carrier Alice; Isnardon Daniel; Cecchinelli Barbara; Soddu Silvia; Malissen Bernard; Dagorn Jean-Charles; Iovanna Juan L; Dusetti Nelson J (Sep 2003). "TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity". J. Biol. Chem. (United States) 278 (39): 37722–9. doi:10.1074/jbc.M301979200. ISSN 0021-9258. PMID 12851404.
  9. ↑ Wang, Ying; Marion Schneider E; Li Xin; Duttenhöfer Irina; Debatin Klaus; Hug Hubert (Sep 2002). "HIPK2 associates with RanBPM". Biochem. Biophys. Res. Commun. (United States) 297 (1): 148–53. doi:10.1016/S0006-291X(02)02020-X. ISSN 0006-291X. PMID 12220523.

Further reading

  • Möller A, Schmitz ML (2004). "Viruses as hijackers of PML nuclear bodies". Arch. Immunol. Ther. Exp. (Warsz.) 51 (5): 295–300. PMID 14626429.
  • Calzado MA, Renner F, Roscic A, Schmitz ML (2007). "HIPK2: a versatile switchboard regulating the transcription machinery and cell death". Cell Cycle 6 (2): 139–43. doi:10.4161/cc.6.2.3788. PMID 17245128.
  • Kim YH, Choi CY, Lee SJ et al. (1998). "Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors". J. Biol. Chem. 273 (40): 25875–9. doi:10.1074/jbc.273.40.25875. PMID 9748262.
  • Kim YH, Choi CY, Kim Y (1999). "Covalent modification of the homeodomain-interacting protein kinase 2 (HIPK2) by the ubiquitin-like protein SUMO-1". Proc. Natl. Acad. Sci. U.S.A. 96 (22): 12350–5. doi:10.1073/pnas.96.22.12350. PMC 22920. PMID 10535925.
  • Choi CY, Kim YH, Kwon HJ, Kim Y (1999). "The homeodomain protein NK-3 recruits Groucho and a histone deacetylase complex to repress transcription". J. Biol. Chem. 274 (47): 33194–7. doi:10.1074/jbc.274.47.33194. PMID 10559189.
  • Li X, Wang Y, Debatin KM, Hug H (2000). "The serine/threonine kinase HIPK2 interacts with TRADD, but not with CD95 or TNF-R1 in 293T cells". Biochem. Biophys. Res. Commun. 277 (2): 513–7. doi:10.1006/bbrc.2000.3700. PMID 11032752.
  • Wang Y, Hofmann TG, Runkel L et al. (2001). "Isolation and characterization of cDNAs for the protein kinase HIPK2". Biochim. Biophys. Acta 1518 (1–2): 168–72. doi:10.1016/S0167-4781(00)00308-0. PMID 11267674.
  • Missero C, Pirro MT, Simeone S et al. (2001). "The DNA glycosylase T:G mismatch-specific thymine DNA glycosylase represses thyroid transcription factor-1-activated transcription". J. Biol. Chem. 276 (36): 33569–75. doi:10.1074/jbc.M104963200. PMID 11438542.
  • Wang Y, Debatin KM, Hug H (2003). "HIPK2 overexpression leads to stabilization of p53 protein and increased p53 transcriptional activity by decreasing Mdm2 protein levels". BMC Mol. Biol. 2: 8. doi:10.1186/1471-2199-2-8. PMC 48146. PMID 11532197.
  • Pierantoni GM, Fedele M, Pentimalli F et al. (2001). "High mobility group I (Y) proteins bind HIPK2, a serine-threonine kinase protein which inhibits cell growth". Oncogene 20 (43): 6132–41. doi:10.1038/sj.onc.1204635. PMID 11593421.
  • Hofmann TG, Möller A, Sirma H et al. (2002). "Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2". Nat. Cell Biol. 4 (1): 1–10. doi:10.1038/ncb715. PMID 11740489.
  • D'Orazi G, Cecchinelli B, Bruno T et al. (2002). "Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis". Nat. Cell Biol. 4 (1): 11–9. doi:10.1038/ncb714. PMID 11780126.
  • Pierantoni GM, Bulfone A, Pentimalli F et al. (2002). "The homeodomain-interacting protein kinase 2 gene is expressed late in embryogenesis and preferentially in retina, muscle, and neural tissues". Biochem. Biophys. Res. Commun. 290 (3): 942–7. doi:10.1006/bbrc.2001.6310. PMID 11798164.
  • Kim EJ, Park JS, Um SJ (2002). "Identification and characterization of HIPK2 interacting with p73 and modulating functions of the p53 family in vivo". J. Biol. Chem. 277 (35): 32020–8. doi:10.1074/jbc.M200153200. PMID 11925430.
  • Wang Y, Marion Schneider E, Li X et al. (2002). "HIPK2 associates with RanBPM". Biochem. Biophys. Res. Commun. 297 (1): 148–53. doi:10.1016/S0006-291X(02)02020-X. PMID 12220523.
  • Scherer SW, Cheung J, MacDonald JR et al. (2003). "Human chromosome 7: DNA sequence and biology". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
  • Tomasini R, Samir AA, Carrier A et al. (2003). "TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity". J. Biol. Chem. 278 (39): 37722–9. doi:10.1074/jbc.M301979200. PMID 12851404.
  • Hillier LW, Fulton RS, Fulton LA et al. (2003). "The DNA sequence of human chromosome 7". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
  • Harada J, Kokura K, Kanei-Ishii C et al. (2003). "Requirement of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activation". J. Biol. Chem. 278 (40): 38998–9005. doi:10.1074/jbc.M307112200. PMID 12874272.