HECW2

HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2LFE

Identifiers

HECW2 ; NEDL2

External IDs

OMIM: None HomoloGene: 66192 GeneCards: HECW2 Gene

Gene ontology
Molecular function	• ubiquitin-protein transferase activity • ligase activity
Cellular component	• nucleus • cytoplasm
Biological process	• protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

ENSG00000138411

ENSMUSG00000042807

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 2:
196.19 – 196.59 Mb

Chr 1:
53.81 – 54.2 Mb

PubMed search

HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 is a protein that in humans is encoded by the HECW2 gene. ^[1]

References

↑ "Entrez Gene: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2". Retrieved 2014-10-24.

Further reading

Miyazaki, K; Ozaki, T; Kato, C; Hanamoto, T; Fujita, T; Irino, S; Watanabe, K; Nakagawa, T; Nakagawara, A (2003). "A novel HECT-type E3 ubiquitin ligase, NEDL2, stabilizes p73 and enhances its transcriptional activity". Biochemical and biophysical research communications 308 (1): 106–13. PMID 12890487.
Cui, Y; He, S; Xing, C; Lu, K; Wang, J; Xing, G; Meng, A; Jia, S; He, F; Zhang, L (2011). "SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1". The EMBO Journal 30 (13): 2675–89. doi:10.1038/emboj.2011.155. PMC 3155294. PMID 21572392.