HDAC7
Histone deacetylase 7 is an enzyme that in humans is encoded by the HDAC7 gene.[1][2][3]
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via transcriptional corepressor SMRT. Multiple alternatively spliced transcript variants encoding several isoforms have been found for this gene.[3]
Interactions
HDAC7A has been shown to interact with Endothelin receptor type A,[4] HDAC3,[5] HTATIP,[6] BCL6,[7] Nuclear receptor co-repressor 1[5] and IKZF1.[8]
See also
References
- ↑ Marks PA, Richon VM, Rifkind RA (Aug 2000). "Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells". J Natl Cancer Inst 92 (15): 1210–6. doi:10.1093/jnci/92.15.1210. PMID 10922406.
- ↑ Kao HY, Downes M, Ordentlich P, Evans RM (Feb 2000). "Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression". Genes Dev 14 (1): 55–66. doi:10.1101/gad.14.1.55. PMC 316336. PMID 10640276.
- ↑ 3.0 3.1 "Entrez Gene: HDAC7A histone deacetylase 7A".
- ↑ Lee, H J; Chun M; Kandror K V (May 2001). "Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream signaling". J. Biol. Chem. (United States) 276 (20): 16597–600. doi:10.1074/jbc.C000909200. ISSN 0021-9258. PMID 11262386.
- ↑ 5.0 5.1 Fischle, W; Dequiedt F; Fillion M; Hendzel M J; Voelter W; Verdin E (Sep 2001). "Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo". J. Biol. Chem. (United States) 276 (38): 35826–35. doi:10.1074/jbc.M104935200. ISSN 0021-9258. PMID 11466315.
- ↑ Xiao, Hui; Chung Jin; Kao Hung-Ying; Yang Yu-Chung (Mar 2003). "Tip60 is a co-repressor for STAT3". J. Biol. Chem. (United States) 278 (13): 11197–204. doi:10.1074/jbc.M210816200. ISSN 0021-9258. PMID 12551922.
- ↑ Lemercier, Claudie; Brocard Marie-Paule, Puvion-Dutilleul Francine, Kao Hung-Ying, Albagli Olivier, Khochbin Saadi (Jun 2002). "Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor". J. Biol. Chem. (United States) 277 (24): 22045–52. doi:10.1074/jbc.M201736200. ISSN 0021-9258. PMID 11929873.
- ↑ Koipally, Joseph; Georgopoulos Katia (Aug 2002). "A molecular dissection of the repression circuitry of Ikaros". J. Biol. Chem. (United States) 277 (31): 27697–705. doi:10.1074/jbc.M201694200. ISSN 0021-9258. PMID 12015313.
Further reading
- Verdin E, Dequiedt F, Kasler HG (2003). "Class II histone deacetylases: versatile regulators.". Trends Genet. 19 (5): 286–93. doi:10.1016/S0168-9525(03)00073-8. PMID 12711221.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Lee HJ, Chun M, Kandror KV (2001). "Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream signaling". J. Biol. Chem. 276 (20): 16597–600. doi:10.1074/jbc.C000909200. PMID 11262386.
- Fischle W, Dequiedt F, Fillion M et al. (2001). "Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo". J. Biol. Chem. 276 (38): 35826–35. doi:10.1074/jbc.M104935200. PMID 11466315.
- Lemercier C, Brocard MP, Puvion-Dutilleul F et al. (2002). "Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor". J. Biol. Chem. 277 (24): 22045–52. doi:10.1074/jbc.M201736200. PMID 11929873.
- Bryant H, Farrell PJ (2002). "Signal Transduction and Transcription Factor Modification during Reactivation of Epstein-Barr Virus from Latency". J. Virol. 76 (20): 10290–8. doi:10.1128/JVI.76.20.10290-10298.2002. PMC 136559. PMID 12239305.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Xiao H, Chung J, Kao HY, Yang YC (2003). "Tip60 is a co-repressor for STAT3". J. Biol. Chem. 278 (13): 11197–204. doi:10.1074/jbc.M210816200. PMID 12551922.
- Dequiedt F, Kasler H, Fischle W et al. (2003). "HDAC7, a thymus-specific class II histone deacetylase, regulates Nur77 transcription and TCR-mediated apoptosis". Immunity 18 (5): 687–98. doi:10.1016/S1074-7613(03)00109-2. PMID 12753745.
- Lee CH, Chawla A, Urbiztondo N et al. (2003). "Transcriptional repression of atherogenic inflammation: modulation by PPARdelta". Science 302 (5644): 453–7. doi:10.1126/science.1087344. PMID 12970571.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Li X, Song S, Liu Y et al. (2004). "Phosphorylation of the histone deacetylase 7 modulates its stability and association with 14-3-3 proteins". J. Biol. Chem. 279 (33): 34201–8. doi:10.1074/jbc.M405179200. PMID 15166223.
- Kato H, Tamamizu-Kato S, Shibasaki F (2004). "Histone deacetylase 7 associates with hypoxia-inducible factor 1alpha and increases transcriptional activity". J. Biol. Chem. 279 (40): 41966–74. doi:10.1074/jbc.M406320200. PMID 15280364.
- Beausoleil SA, Jedrychowski M, Schwartz D et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Jin J, Smith FD, Stark C et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
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External links
- HDAC7A protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.