HCLS1

Hematopoietic cell-specific Lyn substrate 1

Identifiers

HCLS1 ; CTTNL; HS1; lckBP1; p75

External IDs

OMIM: 601306 MGI: 104568 HomoloGene: 38034 GeneCards: HCLS1 Gene

Gene ontology
Molecular function	• RNA polymerase II transcription factor binding • actin binding • protein binding • SH3 domain binding • protein kinase binding • protein complex binding
Cellular component	• nucleus • transcription factor complex • cytoplasm • mitochondrion • membrane
Biological process	• negative regulation of transcription from RNA polymerase II promoter • regulation of transcription, DNA-templated • positive regulation of cell proliferation • response to hormone • positive regulation of phosphatidylinositol 3-kinase signaling • actin filament polymerization • erythrocyte differentiation • regulation of actin filament polymerization • positive regulation of granulocyte differentiation • positive regulation of peptidyl-serine phosphorylation • intracellular signal transduction • positive regulation of tyrosine phosphorylation of STAT protein • positive regulation of transcription factor import into nucleus • positive regulation of macrophage differentiation • positive regulation of transcription from RNA polymerase II promoter • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of protein kinase B signaling • cellular response to cytokine stimulus • negative regulation of leukocyte apoptotic process • positive regulation of actin cytoskeleton reorganization
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000180353

ENSMUSG00000022831

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 3:
121.35 – 121.38 Mb

Chr 16:
36.93 – 36.96 Mb

PubMed search

Hematopoietic lineage cell-specific protein is a protein that in humans is encoded by the HCLS1 gene.^[1]^[2]^[3]

Interactions

HCLS1 has been shown to interact with Caspase 3.^[4]^[5]

References

↑ Egashira M, Kitamura D, Watanabe T, Niikawa N (Jan 1997). "The human HCLS1 gene maps to chromosome 3q13 by fluorescence in situ hybridization". Cytogenet Cell Genet 72 (2-3): 175–6. doi:10.1159/000134179. PMID 8978766.
↑ van Rossum AG, Schuuring-Scholtes E, van Buuren-van Seggelen V, Kluin PM, Schuuring E (Mar 2005). "Comparative genome analysis of cortactin and HS1: the significance of the F-actin binding repeat domain". BMC Genomics 6: 15. doi:10.1186/1471-2164-6-15. PMC 554100. PMID 15710041.
↑ "Entrez Gene: HCLS1 hematopoietic cell-specific Lyn substrate 1".
↑ Ruzzene, Maria; Penzo Daniele; Pinna Lorenzo A (May 2002). "Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells". Biochem. J. (England) 364 (Pt 1): 41–7. ISSN 0264-6021. PMC 1222543. PMID 11988074.
↑ Chen, Y R; Kori R; John B; Tan T H (Nov 2001). "Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis". Biochem. Biophys. Res. Commun. (United States) 288 (4): 981–9. doi:10.1006/bbrc.2001.5862. ISSN 0006-291X. PMID 11689006.

Further reading

Kitamura D, Kaneko H, Miyagoe Y et al. (1990). "Isolation and characterization of a novel human gene expressed specifically in the cells of hematopoietic lineage.". Nucleic Acids Res. 17 (22): 9367–79. PMC 335138. PMID 2587259.
Yamanashi Y, Okada M, Semba T et al. (1993). "Identification of HS1 protein as a major substrate of protein-tyrosine kinase(s) upon B-cell antigen receptor-mediated signaling.". Proc. Natl. Acad. Sci. U.S.A. 90 (8): 3631–5. doi:10.1073/pnas.90.8.3631. PMC 46355. PMID 7682714.
Hata D, Nakamura T, Kawakami T et al. (1994). "Tyrosine phosphorylation of MB-1, B29, and HS1 proteins in human B cells following receptor crosslinking.". Immunol. Lett. 40 (1): 65–71. doi:10.1016/0165-2478(94)90208-9. PMID 7927516.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Egerton M, Moritz RL, Druker B et al. (1996). "Identification of the 70kD heat shock cognate protein (Hsc70) and alpha-actinin-1 as novel phosphotyrosine-containing proteins in T lymphocytes.". Biochem. Biophys. Res. Commun. 224 (3): 666–74. doi:10.1006/bbrc.1996.1082. PMID 8713105.
Suzuki Y, Demoliere C, Kitamura D et al. (1997). "HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src family tyrosine kinases.". J. Immunol. 158 (6): 2736–44. PMID 9058808.
Yamanashi Y, Fukuda T, Nishizumi H et al. (1997). "Role of tyrosine phosphorylation of HS1 in B cell antigen receptor-mediated apoptosis.". J. Exp. Med. 185 (7): 1387–92. doi:10.1084/jem.185.7.1387. PMC 2196252. PMID 9104825.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Brunati AM, Donella-Deana A, James P et al. (1999). "Molecular features underlying the sequential phosphorylation of HS1 protein and its association with c-Fgr protein-tyrosine kinase.". J. Biol. Chem. 274 (11): 7557–64. doi:10.1074/jbc.274.11.7557. PMID 10066823.
Nagata Y, Kiefer F, Watanabe T, Todokoro K (1999). "Activation of hematopoietic progenitor kinase-1 by erythropoietin.". Blood 93 (10): 3347–54. PMID 10233887.
Takemoto Y, Furuta M, Sato M et al. (2000). "Isolation and characterization of a novel HS1 SH3 domain binding protein, HS1BP3.". Int. Immunol. 11 (12): 1957–64. doi:10.1093/intimm/11.12.1957. PMID 10590261.
Ruzzene M, Brunati AM, Sarno S et al. (2000). "Ser/Thr phosphorylation of hematopoietic specific protein 1 (HS1): implication of protein kinase CK2.". Eur. J. Biochem. 267 (10): 3065–72. doi:10.1046/j.1432-1033.2000.01333.x. PMID 10806407.
Chen YR, Kori R, John B, Tan TH (2001). "Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis.". Biochem. Biophys. Res. Commun. 288 (4): 981–9. doi:10.1006/bbrc.2001.5862. PMID 11689006.
Ruzzene M, Penzo D, Pinna LA (2002). "Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells.". Biochem. J. 364 (Pt 1): 41–7. PMC 1222543. PMID 11988074.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Salomon AR, Ficarro SB, Brill LM et al. (2003). "Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 443–8. doi:10.1073/pnas.2436191100. PMC 141014. PMID 12522270.
Uruno T, Zhang P, Liu J et al. (2003). "Haematopoietic lineage cell-specific protein 1 (HS1) promotes actin-related protein (Arp) 2/3 complex-mediated actin polymerization.". Biochem. J. 371 (Pt 2): 485–93. doi:10.1042/BJ20021791. PMC 1223309. PMID 12534372.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Brill LM, Salomon AR, Ficarro SB et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.