HBXIP

Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5

Rendering based on PDB 3MS6.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
3MS6, 3MSH

Identifiers

LAMTOR5 ; HBXIP; XIP

External IDs

OMIM: 608521 MGI: 1915826 HomoloGene: 4668 GeneCards: LAMTOR5 Gene

Gene ontology
Molecular function	• guanyl-nucleotide exchange factor activity • protein binding • protein complex scaffold
Cellular component	• lysosome • cytosol • Ragulator complex
Biological process	• regulation of cell size • response to virus • viral genome replication • positive regulation of TOR signaling • negative regulation of apoptotic process • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of GTPase activity • protein localization to lysosome • cellular response to amino acid stimulus
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000134248

ENSMUSG00000087260

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
110.94 – 110.95 Mb

Chr 3:
107.28 – 107.28 Mb

PubMed search

Hepatitis B virus X-interacting protein is a protein that in humans is encoded by the HBXIP gene.^[1]^[2]

This gene encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx). The function of this protein is to negatively regulate HBx activity and thus to alter the replication life cycle of the virus.^[2]

Interactions

HBXIP has been shown to interact with NCOA6.^[3]

References

↑ Melegari M, Scaglioni PP, Wands JR (Mar 1998). "Cloning and Characterization of a Novel Hepatitis B Virus x Binding Protein That Inhibits Viral Replication". J Virol 72 (3): 1737–43. PMC 109461. PMID 9499022.
↑ 2.0 2.1 "Entrez Gene: HBXIP hepatitis B virus x interacting protein".
↑ Kong, Hee Jeong; Park Min Jung; Hong SunHwa; Yu Hyun Jung; Lee Young Chul; Choi Young Hyun; Cheong JaeHun (Nov 2003). "Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2". Hepatology (United States) 38 (5): 1258–66. doi:10.1053/jhep.2003.50451. ISSN 0270-9139. PMID 14578865.

Further reading

Shamay M; Barak O; Doitsh G et al. (2002). "Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to coactivate transcription". J. Biol. Chem. 277 (12): 9982–8. doi:10.1074/jbc.M111354200. PMID 11788598.
Li Y, Lu YY (2002). "Applying a highly specific and reproducible cDNA RDA method to clone garlic up-regulated genes in human gastric cancer cells". World J. Gastroenterol. 8 (2): 213–6. PMID 11925594.
Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Marusawa H; Matsuzawa S; Welsh K et al. (2003). "HBXIP functions as a cofactor of survivin in apoptosis suppression". EMBO J. 22 (11): 2729–40. doi:10.1093/emboj/cdg263. PMC 156760. PMID 12773388.
Kong HJ; Park MJ; Hong S et al. (2003). "Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2". Hepatology 38 (5): 1258–66. doi:10.1053/jhep.2003.50451. PMID 14578865.
Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Lee SH, Park SG, Lim SO, Jung G (2005). "The hepatitis B virus X protein up-regulates lymphotoxin alpha expression in hepatocytes". Biochim. Biophys. Acta 1741 (1–2): 75–84. doi:10.1016/j.bbadis.2004.10.004. PMID 15955450.
Lee AT; Ren J; Wong ET et al. (2005). "The hepatitis B virus X protein sensitizes HepG2 cells to UV light-induced DNA damage". J. Biol. Chem. 280 (39): 33525–35. doi:10.1074/jbc.M506628200. PMID 16055925.
Stelzl U; Worm U; Lalowski M et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Minczuk M, Mroczek S, Pawlak SD, Stepien PP (2005). "Human ATP-dependent RNA/DNA helicase hSuv3p interacts with the cofactor of survivin HBXIP". FEBS J. 272 (19): 5008–19. doi:10.1111/j.1742-4658.2005.04910.x. PMID 16176273.
Muroyama R; Kato N; Yoshida H et al. (2007). "Nucleotide change of codon 38 in the X gene of hepatitis B virus genotype C is associated with an increased risk of hepatocellular carcinoma". J. Hepatol. 45 (6): 805–12. doi:10.1016/j.jhep.2006.07.025. PMID 17050029.
Chen J, Siddiqui A (2007). "Hepatitis B Virus X Protein Stimulates the Mitochondrial Translocation of Raf-1 via Oxidative Stress". J. Virol. 81 (12): 6757–60. doi:10.1128/JVI.00172-07. PMC 1900104. PMID 17428866.