Gurupí River
- This article is about the river; for the town, see Gurupi
The Gurupí River is a river in north-central Brazil which forms the boundary between Maranhão and Pará states. The Gurupí rises in the low hills which separate its basin from that of the Tocantins River to the south, and flows north into the Atlantic Ocean. The Serra do Tiracambu lies to the east, and separates the basin of the Gurupí from that of the Pindaré River.
The Gurupí basin is home to tropical moist broadleaf forest, and lies within the Tocantins-Araguaia-Maranhão moist forests ecoregion.