Guanylate cyclase activator

A guanylate cyclase activator (or "GUCA") is one of group of proteins which upregulates guanylate cyclase. It is also known as guanylate cyclase-activating protein, with the abbreviation "GCAP".Mutations can be associated with vision defects.^[1]

There are five genes involved:

• GUCA1A, GUCA1B, GUCA1C
• GUCA2A, GUCA2B

References

1. ↑ Payne AM, Downes SM, Bessant DA et al. (1998). "A mutation in guanylate cyclase activator 1A (GUCA1A) in an autosomal dominant cone dystrophy pedigree mapping to a new locus on chromosome 6p21.1". Hum. Mol. Genet. 7 (2): 273–7. doi:10.1093/hmg/7.2.273. PMID 9425234.  CS1 maint: Explicit use of et al. (link)

External links

• Guanylate Cyclase-Activating Proteins at the US National Library of Medicine Medical Subject Headings (MeSH)