Granulocyte macrophage colony-stimulating factor receptor

Colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsCSF2RA ; CD116; CDw116; CSF2R; CSF2RAX; CSF2RAY; CSF2RX; CSF2RY; GM-CSF-R-alpha; GMCSFR; GMR; SMDP4
External IDsOMIM: 425000 MGI: 1339754 HomoloGene: 48406 IUPHAR: 1707 ChEMBL: 2020 GeneCards: CSF2RA Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez143812982
EnsemblENSG00000198223ENSMUSG00000059326
UniProtP15509Q00941
RefSeq (mRNA)NM_001161529NM_009970
RefSeq (protein)NP_001155001NP_034100
Location (UCSC)Chr X:
1.39 – 1.43 Mb		Chr 19:
61.22 – 61.23 Mb
PubMed search

The granulocyte macrophage colony-stimulating factor receptor also known as CD116 (Cluster of Differentiation 116), is a receptor for granulocyte macrophage colony-stimulating factor, which stimulates the production of white blood cells. The receptor is normally located on myeloblast, mature neutrophil, but not on any erythroid or megakaryocytic lineage cells.[1]

It is associated with Surfactant metabolism dysfunction type 4.

Structure

The granulocyte macrophage colony-stimulating factor receptor is a heterodimer composed of at least two different subunits; an α chain, and a β chain which is also present in the receptors for IL-3 and IL-5. The α subunit contains a binding site for granulocyte macrophage colony-stimulating factor.[2] The β chain is involved in signal transduction. Association of the α and β subunits results in receptor activation.[3]

Signal transduction

Upon dimerisation of the α and β subunits the β subunit becomes phosphorylated on tyrosine residues by members of the Janus kinase (JAK) family.[3] This leads to association with a Shc adaptor protein. Then Shc interacts with GRB2/SoS complex which results in activation of more downstream molecules in the pathway.[4]

References

  1. ↑ Nicola NA, Metcalf D (1985). "Binding of 125I-labeled granulocyte colony-stimulating factor to normal murine hemopoietic cells". J. Cell. Physiol. 124 (2): 313–321. doi:10.1002/jcp.1041240222. PMID 3876343.
  2. ↑ McClure BJ, Hercus TR, Cambareri BA, Woodcock JM, Bagley CJ, Howlett GJ, Lopez AF (2003). "Molecular assembly of the ternary granulocyte-macrophage colony-stimulating factor receptor complex". Blood 101 (4): 1308–1315. doi:10.1182/blood-2002-06-1903. PMID 12393492.
  3. ↑ 3.0 3.1 Geijsen N, Koenderman L, Coffer PJ (2001). "Specificity in cytokine signal transduction: lessons learned from the IL-3/IL-5/GM-CSF receptor family". Cytokine Growth Factor Rev. 12 (1): 19–25. doi:10.1016/S1359-6101(00)00019-8. PMID 11312115.
  4. ↑ Doyle SE, Gasson JC (1998). "Characterization of the role of the human granulocyte-macrophage colony-stimulating factor receptor alpha subunit in the activation of JAK2 and STAT5" (– SCHOLAR SEARCH). Blood 92 (3): 867–76. PMID 9680354.

Further reading

  • Rappold G, Willson TA, Henke A, Gough NM (1992). "Arrangement and localization of the human GM-CSF receptor alpha chain gene CSF2RA within the X-Y pseudoautosomal region". Genomics 14 (2): 455–461. doi:10.1016/S0888-7543(05)80241-1. PMID 1358805.
  • Hayashida K; Kitamura T; Gorman DM et al. (1991). "Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor". Proc. Natl. Acad. Sci. U.S.A. 87 (24): 9655–9659. doi:10.1073/pnas.87.24.9655. PMC 55231. PMID 1702217.
  • Crosier KE; Wong GG; Mathey-Prevot B et al. (1991). "A functional isoform of the human granulocyte/macrophage colony-stimulating factor receptor has an unusual cytoplasmic domain". Proc. Natl. Acad. Sci. U.S.A. 88 (17): 7744–7748. doi:10.1073/pnas.88.17.7744. PMC 52379. PMID 1715577.
  • Raines MA; Liu L; Quan SG et al. (1991). "Identification and molecular cloning of a soluble human granulocyte-macrophage colony-stimulating factor receptor". Proc. Natl. Acad. Sci. U.S.A. 88 (18): 8203–8207. doi:10.1073/pnas.88.18.8203. PMC 52475. PMID 1832774.
  • Gough NM; Gearing DP; Nicola NA et al. (1990). "Localization of the human GM-CSF receptor gene to the X-Y pseudoautosomal region". Nature 345 (6277): 734–736. doi:10.1038/345734a0. PMID 1972780.
  • Ashworth A, Kraft A (1991). "Cloning of a potentially soluble receptor for human GM-CSF". Nucleic Acids Res. 18 (23): 7178–7178. doi:10.1093/nar/18.23.7178. PMC 332824. PMID 2148207.
  • Gearing DP, King JA, Gough NM, Nicola NA (1990). "Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor". EMBO J. 8 (12): 3667–76. PMC 402049. PMID 2555171.
  • DiPersio J; Billing P; Kaufman S et al. (1988). "Characterization of the human granulocyte-macrophage colony-stimulating factor receptor". J. Biol. Chem. 263 (4): 1834–41. PMID 2828352.
  • Williams WV; VonFeldt JM; Rosenbaum H et al. (1994). "Molecular cloning of a soluble form of the granulocyte-macrophage colony-stimulating factor receptor alpha chain from a myelomonocytic cell line. Expression, biologic activity, and preliminary analysis of transcript distribution". Arthritis Rheum. 37 (10): 1468–1478. doi:10.1002/art.1780371010. PMID 7945472.
  • Jubinsky PT; Laurie AS; Nathan DG et al. (1995). "Expression and function of the human granulocyte-macrophage colony-stimulating factor receptor alpha subunit". Blood 84 (12): 4174–85. PMID 7994031.
  • Hu X, Emanuel PD, Zuckerman KS (1994). "Cloning and sequencing of the cDNAs encoding two alternative splicing-derived variants of the alpha subunit of the granulocyte-macrophage colony-stimulating factor receptor". Biochim. Biophys. Acta 1223 (2): 306–308. doi:10.1016/0167-4889(94)90241-0. PMID 8086503.
  • Nakagawa Y; Kosugi H; Miyajima A et al. (1994). "Structure of the gene encoding the alpha subunit of the human granulocyte-macrophage colony stimulating factor receptor. Implications for the evolution of the cytokine receptor superfamily". J. Biol. Chem. 269 (14): 10905–12. PMID 8144676.
  • Zhao Y, Rong H, Chegini N (1996). "Expression and selective cellular localization of granulocyte-macrophage colony-stimulating factor (GM-CSF) and GM-CSF alpha and beta receptor messenger ribonucleic acid and protein in human ovarian tissue". Biol. Reprod. 53 (4): 923–930. doi:10.1095/biolreprod53.4.923. PMID 8547489.
  • Lia F, Rajotte D, Clark SC, Hoang T (1996). "A dominant negative granulocyte-macrophage colony-stimulating factor receptor alpha chain reveals the multimeric structure of the receptor complex". J. Biol. Chem. 271 (45): 28287–28293. doi:10.1074/jbc.271.45.28287. PMID 8910448.
  • Wei S; Liu JH; Epling-Burnette PK et al. (1996). "Critical role of Lyn kinase in inhibition of neutrophil apoptosis by granulocyte-macrophage colony-stimulating factor". J. Immunol. 157 (11): 5155–62. PMID 8943427.
  • Soldi R; Primo L; Brizzi MF et al. (1997). "Activation of JAK2 in human vascular endothelial cells by granulocyte-macrophage colony-stimulating factor". Blood 89 (3): 863–72. PMID 9028317.
  • Matsuguchi T, Zhao Y, Lilly MB, Kraft AS (1997). "The cytoplasmic domain of granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor alpha subunit is essential for both GM-CSF-mediated growth and differentiation". J. Biol. Chem. 272 (28): 17450–17459. doi:10.1074/jbc.272.28.17450. PMID 9211889.
  • Rivas CI; Vera JC; Delgado-López F et al. (1998). "Expression of granulocyte-macrophage colony-stimulating factor receptors in human prostate cancer". Blood 91 (3): 1037–43. PMID 9446667.
  • Hu X, Zuckerman KS (1998). "Cloning and sequencing of an alternative splicing-derived cDNA variant of the GM-CSF receptor alpha subunit, which encodes a truncated protein". Am. J. Hematol. 58 (2): 145–147. doi:10.1002/(SICI)1096-8652(199806)58:2<145::AID-AJH11>3.0.CO;2-A. PMID 9625584.
  • Taha RA; Leung DY; Ghaffar O et al. (1998). "In vivo expression of cytokine receptor mRNA in atopic dermatitis". J. Allergy Clin. Immunol. 102 (2): 245–250. doi:10.1016/S0091-6749(98)70093-4. PMID 9723668.

External links