George Little
George Little may refer to:
- George E. Little, Pentagon/Department of Defense press secretary
- George Little (actor), English TV actor and father of Tasmin Little
- George Little (American football coach) (1889–1957), American football and basketball coach, 1914–1926
- George Little (defensive lineman) (born 1953), American football player
- George Little (Manitoba politician) (died 1940), Manitoba MLA
- George Little (naval officer) (1754–1809), American naval officer during the Revolutionary War
- George Little (New Brunswick politician) (born 1937), leader of the New Democratic Party of New Brunswick
- George Little (North Carolina) (born 1942), Republican politician from North Carolina
- George W. Little, New York politician
- George Little (character), older brother of film character Stuart Little