Gene Tools

Gene Tools, LLC is a limited liability company located in Philomath, Oregon, United States that manufactures Morpholino antisense oligos and delivery reagents.[1][2] Gene Tools was founded in 1997 and began regularly shipping custom-sequence Morpholino oligos in 2000. Current products include Morpholino oligos, Vivo-Morpholinos (for improved delivery into cells) and Photo-Morpholinos (cleavable by 365nm light).

The manager and general partner, Dr. Jim Summerton, is a pioneer in antisense research,[3] conceived of and was co-inventor of the Morpholino antisense oligo structural type[4] and founded the first antisense therapeutics company, Sarepta Therapeutics Inc. (formerly AntiVirals Inc., renamed AVI BioPharma Inc., renamed Sarepta Therapeutics Inc.).

Sources

  1. ↑ Summerton, JE (2005). "Endo-porter: a novel reagent for safe, effective delivery of substances into cells.". Ann N Y Acad Sci 1058: 62–75. doi:10.1196/annals.1359.012. PMID 16394126.
  2. ↑ Morcos, PA (2001). "Achieving efficient delivery of morpholino oligos in cultured cells.". Genesis 30 (3): 94–102. doi:10.1002/gene.1039. PMID 11477682.
  3. ↑ Summerton, JE (May 1979). "Intracellular inactivation of specific nucleotide sequences: a general approach to the treatment of viral diseases and virally-mediated cancers.". J. Theor. Biol. 78 (1): 77–99. doi:10.1016/0022-5193(79)90327-8. PMID 114718.
  4. ↑ Summerton, J; Weller D (1997). "Morpholino Antisense Oligomers: Design, Preparation and Properties.". Antisense & Nucleic Acid Drug Development 7 (3): 187–95. doi:10.1089/oli.1.1997.7.187. PMID 9212909.

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