Gelonin

Gelonin is a protein toxin of approximately 30 kDa found in the seeds of the Himalayan plant Gelonium multiflorum. In cell-free systems gelonin exerts powerful N-glycosidase activity on the 28S rRNA unit of eukaryotic ribosomes by cleaving out adenine at the 4324 site.

See also

• Saporin

References

• Stirpe, F., Olsnes, S. & Pihl, A. Gelonin, a new inhibitor of protein synthesis, nontoxic to intact cells. Isolation, characterization, and preparation of cytotoxic complexes with concanavalin A. J. Biol. Chem. 255, 6947-6953 (1980)