Gallamine triethiodide

Gallamine triethiodide
Systematic (IUPAC) name
2,2’,2’’-[benzene-1,2,3-triyltris(oxy)]tris(N,N,N-triethylethanaminium) triiodide
Clinical data
Trade names Flaxedil
AHFS/Drugs.com International Drug Names
Identifiers
65-29-2 Yes
M03AC02
PubChem CID 6172
IUPHAR ligand 356
DrugBank DB00483 Yes
ChemSpider 5937 
UNII Q3254X40X2 Yes
KEGG D02292 Yes
ChEBI CHEBI:503442 Yes
ChEMBL CHEMBL1200993 
Chemical data
Formula C30H60N3O3+3 · 3 I− (gallamine triethiodide)
C24H45N3O3 (gallamine)
891.529 g/mol (gallamine triethiodide)
423.633 g/mol
(gallamine)
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Gallamine triethiodide (Flaxedil) is a non-depolarising muscle relaxant.[1] It acts by combining with the cholinergic receptor sites in muscle and competitively blocking the transmitter action of acetylcholine.[2] Gallamine triethiodide has a parasympatholytic effect on the cardiac vagus nerve which causes tachycardia[3][4] and occasionally hypertension. Very high doses cause histamine release.

Gallamine triethiodide is commonly used to stabilize muscle contractions during surgical procedures.

It was developed by Daniel Bovet in 1947.[5]

The pharmaceutical is no longer marketed in the United States, according to the FDA Orange Book.

An ampoule of gallamine.

References

  1. ↑ "Webster's Online Dictionary - Flaxedil". Retrieved 2008-12-15.
  2. ↑ "RxMed: Pharmaceutical Information - FLAXEDIL". Retrieved 2008-12-15.
  3. ↑ Morgenstern C, Splith G (October 1965). "[Studies on the causes of gallamine tachycardia and its antagonistic modification by beta adrenolytics]". Der Anaesthesist (in German) 14 (10): 298–301. PMID 4380161.
  4. ↑ WALTS LF (1963). "Ventricular tachycardia with gallamine and cyclopropane anesthesia". Anesthesiology 24: 119. doi:10.1097/00000542-196301000-00024. PMID 13998750. Retrieved 2014-09-20.
  5. ↑ Raghavendra T (July 2002). "Neuromuscular blocking drugs: discovery and development". J R Soc Med 95 (7): 363–7. doi:10.1258/jrsm.95.7.363. PMC 1279945. PMID 12091515.