Gag/pol translational readthrough site
Gag/pol translational readthrough site (or Retroviral readthrough element) is a cis-regulatory element found in retroviruses.[1] The readthrough site facilitates the mechanism of translation readthrough of the stop codon at the gag-pol junction producing the gag and pol fusion protein in certain retroviruses.
Retroviruses whose gag and pol genes are in the same reading frame often depend upon approximately 5% read-through of the gag UAG termination codon to form the gag-pol polyprotein. This readthrough is usually dependent on a pseudoknot located eight nucleotides downstream of the stop codon (UAG). Sequence conservation is found in the second pseudoknot loop.
Gallery of secondary structure images |
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| | GP_knot2: Secondary structure taken from the Rfam database. Family RF01092. Derived from Pseudobase PKB00048 |
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