GW-803,430
GW-803,430
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Systematic (IUPAC) name |
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6-(4-chlorophenyl)-3-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-3H-thieno[3,2-d]pyrimidin-4-one |
Clinical data |
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Identifiers |
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515141-51-2 |
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None |
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Chemical data |
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Formula |
C25H24ClN3O3S |
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481.993 g/mol |
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SMILES
- C5CCCN5CCOc3ccc(cc3OC)-n1cnc2cc(sc2c1=O)-c(cc4)ccc4Cl
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Y (what is this?) (verify) |
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GW-803,430 (GW-3430) is a drug used in scientific research and is a selective non-peptide antagonist at the melanin concentrating hormone receptor MCH1. In animal studies it has anxiolytic, antidepressant and anorectic effects.[1][2]
References
- ↑ Chaki S, Kanuma K. Neuropeptide receptors: Novel therapeutic targets for depression and anxiety disorders. Drugs of the Future. 2007;32(9):809.
- ↑ Gehlert DR, Rasmussen K, Shaw J, Li X, Ardayfio P, Craft L, Coskun T, Zhang HY, Chen Y, Witkin JM (May 2009). "Preclinical evaluation of melanin-concentrating hormone receptor 1 antagonism for the treatment of obesity and depression". The Journal of Pharmacology and Experimental Therapeutics 329 (2): 429–38. doi:10.1124/jpet.108.143362. PMID 19182070.
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| Non-selective | |
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| MAOA-selective | |
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| MAOB-Selective | |
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| Description | |
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| Disorders |
- Mental and behavioral
- Mood
- Developmental
- pervasive
- dyslexia and specific
- Substance-related
- Emotional and behavioral
- Symptoms and signs
- Evaluation and testing
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| Treatment |
- Psychotherapy
- Drugs
- depression
- antipsychotics
- anxiety
- dementia
- hypnotics and sedatives
- psychostimulants, ADHD and nootropics
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| 5-HT1A agonists | |
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| GABAAR PAMs | |
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| α2δ VDCC blockers | |
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| Antidepressants | |
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| Sympatholytics | |
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| Others | |
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| Description | |
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| Disorders |
- Mental and behavioral
- Mood
- Developmental
- pervasive
- dyslexia and specific
- Substance-related
- Emotional and behavioral
- Symptoms and signs
- Evaluation and testing
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| Treatment |
- Psychotherapy
- Drugs
- depression
- antipsychotics
- anxiety
- dementia
- hypnotics and sedatives
- psychostimulants, ADHD and nootropics
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| Central | |
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| Peripheral | |
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| Description |
- Vitamins
- Cofactors
- Metal metabolism
- Fats
- metabolism
- intermediates
- lipoproteins
- Sugars
- Glycolysis
- Glycogenesis and glycogenolysis
- Fructose and galactose
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| Disease |
- Vitamins
- Carbohydrate
- Lipid
- Metals
- Other
- Symptoms and signs
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| Treatment |
- Drugs
- Vitamins
- Mineral supplements
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| CGRP | |
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| Cholecystokinin | |
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| CRH | |
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| Galanin | |
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| MCH | | |
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- Agonists: Melanin concentrating hormone
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| Melanocortin | | |
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| Unsorted |
- Agonists: Alsactide
- Codactide
- Giractide
- Norleusactide
- Seractide
- Tosactide
- Tricosactide
- Tridecactide
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| Neuropeptide S | |
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| Neuropeptide Y | |
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| Neurotensin | |
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| Opioid | See here instead. |
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| Orexin | |
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| Oxytocin | |
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| Tachykinin | |
- Agonists: Substance P
Antagonists: Aprepitant
- Befetupitant
- Burapitant
- Casopitant
- CI-1021
- CP-96,345
- CP-99,994
- CP-122,721
- Dapitant
- Ezlopitant
- Figopitant
- FK-888
- Fosaprepitant
- GR-203,040
- GW-597,599
- HSP-117
- L-733,060
- L-741,671
- L-743,310
- L-758,298
- Lanepitant
- LY-306,740
- Maropitant
- Netupitant
- NKP-608
- Nolpitantium besilate
- Orvepitant
- Rolapitant
- RP-67,580
- SDZ NKT 343
- Serlopitant
- Telmapitant
- Vestipitant
- Vofopitant
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| Vasopressin | |
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| See also: Peptidergics |
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