GUCY1A3
Guanylate cyclase soluble subunit alpha-3 is an enzyme that in humans is encoded by the GUCY1A3 gene.[1][2]
Function
Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs.[2] Mutations in this gene have been associated to cases of myocardial infarction (10.1038/nature12722).
References
- ↑ Giuili G, Scholl U, Bulle F, Guellaen G (Jul 1992). "Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain". FEBS Lett 304 (1): 83–8. doi:10.1016/0014-5793(92)80594-7. PMID 1352257.
- ↑ 2.0 2.1 "Entrez Gene: GUCY1A3 guanylate cyclase 1, soluble, alpha 3".
Further reading
- Giuili G, Roechel N, Scholl U et al. (1993). "Colocalization of the genes coding for the alpha 3 and beta 3 subunits of soluble guanylyl cyclase to human chromosome 4 at q31.3-q33.". Hum. Genet. 91 (3): 257–60. doi:10.1007/BF00218267. PMID 8097486.
- Papapetropoulos A, Cziraki A, Rubin JW et al. (1996). "cGMP accumulation and gene expression of soluble guanylate cyclase in human vascular tissue.". J. Cell. Physiol. 167 (2): 213–21. doi:10.1002/(SICI)1097-4652(199605)167:2<213::AID-JCP4>3.0.CO;2-S. PMID 8613461.
- Zabel U, Weeger M, La M, Schmidt HH (1998). "Human soluble guanylate cyclase: functional expression and revised isoenzyme family.". Biochem. J. 335 (1): 51–7. PMC 1219751. PMID 9742212.
- Zhou Y, Zheng JB, Gu X et al. (2000). "A novel Pax-6 binding site in rodent B1 repetitive elements: coevolution between developmental regulation and repeated elements?". Gene 245 (2): 319–28. doi:10.1016/S0378-1119(00)00019-6. PMID 10717483.
- Behrends S, Vehse K, Scholz H et al. (2000). "Assignment of GUCY1A3, a candidate gene for hypertension, to human chromosome bands 4q31.1→q31.2 by in situ hybridization.". Cytogenet. Cell Genet. 88 (3–4): 204–5. doi:10.1159/000015548. PMID 10828587.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Saino M, Maruyama T, Sekiya T et al. (2005). "Inhibition of angiogenesis in human glioma cell lines by antisense RNA from the soluble guanylate cyclase genes, GUCY1A3 and GUCY1B3". Oncol. Rep. 12 (1): 47–52. doi:10.3892/or.12.1.47. PMID 15201957.
- Meurer S, Pioch S, Wagner K et al. (2005). "AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase". J. Biol. Chem. 279 (47): 49346–54. doi:10.1074/jbc.M410565200. PMID 15381706.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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