GUCY1A2

Guanylate cyclase 1, soluble, alpha 2
Identifiers
SymbolsGUCY1A2 ; GC-SA2; GUC1A2
External IDsOMIM: 601244 MGI: 2660877 HomoloGene: 47953 IUPHAR: 1289 ChEMBL: 3303 GeneCards: GUCY1A2 Gene
EC number4.6.1.2
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez2977234889
EnsemblENSG00000152402ENSMUSG00000041624
UniProtP33402F8VQK3
RefSeq (mRNA)NM_000855NM_001033322
RefSeq (protein)NP_000846NP_001028494
Location (UCSC)Chr 11:
106.54 – 106.89 Mb		Chr 9:
3.53 – 3.9 Mb
PubMed search

Guanylate cyclase soluble subunit alpha-2 is an enzyme that in humans is encoded by the GUCY1A2 gene.[1][2]

References

  1. ↑ Harteneck C, Wedel B, Koesling D, Malkewitz J, Bohme E, Schultz G (Jan 1992). "Molecular cloning and expression of a new alpha-subunit of soluble guanylyl cyclase. Interchangeability of the alpha-subunits of the enzyme". FEBS Lett 292 (1–2): 217–22. doi:10.1016/0014-5793(91)80871-Y. PMID 1683630.
  2. ↑ "Entrez Gene: GUCY1A2 guanylate cyclase 1, soluble, alpha 2".

Further reading

  • Baba H, Suzuki T, Arai H, Emson PC (2004). "Expression of nNOS and soluble guanylate cyclase in schizophrenic brain". Neuroreport 15 (4): 677–80. doi:10.1097/00001756-200403220-00020. PMID 15094474.
  • Bellamy TC, Wood J, Garthwaite J (2002). "On the activation of soluble guanylyl cyclase by nitric oxide". Proc. Natl. Acad. Sci. U.S.A. 99 (1): 507–10. doi:10.1073/pnas.012368499. PMC 117590. PMID 11752394.
  • Russwurm M, Wittau N, Koesling D (2002). "Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes". J. Biol. Chem. 276 (48): 44647–52. doi:10.1074/jbc.M105587200. PMID 11572861.
  • Bamberger AM; Koglin M; Kempfert J et al. (2001). "Expression and tissue localization of soluble guanylyl cyclase in the human placenta using novel antibodies directed against the alpha(2) subunit". J. Clin. Endocrinol. Metab. 86 (2): 909–12. doi:10.1210/jc.86.2.909. PMID 11158065.
  • Budworth J, Meillerais S, Charles I, Powell K (1999). "Tissue distribution of the human soluble guanylate cyclases". Biochem. Biophys. Res. Commun. 263 (3): 696–701. doi:10.1006/bbrc.1999.1444. PMID 10512742.
  • Yu F, Warburton D, Wellington S, Danziger RS (1997). "Assignment of GUCIA2, the gene coding for the alpha 2 subunit of soluble guanylyl cyclase, to position 11q21-q22 on human chromosome 11". Genomics 33 (2): 334–6. doi:10.1006/geno.1996.0208. PMID 8660992.
  • Behrends S, Harteneck C, Schultz G, Koesling D (1995). "A variant of the alpha 2 subunit of soluble guanylyl cyclase contains an insert homologous to a region within adenylyl cyclases and functions as a dominant negative protein". J. Biol. Chem. 270 (36): 21109–13. doi:10.1074/jbc.270.36.21109. PMID 7673142.