GSPT1

G1 to S phase transition 1

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
3E1Y, 3J5Y, 3KUI

Identifiers

Symbols

GSPT1 ; 551G9.2; ETF3A; GST1; eRF3a

External IDs

OMIM: 139259 MGI: 1316728 HomoloGene: 68226 GeneCards: GSPT1 Gene

Gene ontology
Molecular function	• translation release factor activity • GTPase activity • protein binding • GTP binding • poly(A) RNA binding
Cellular component	• intracellular
Biological process	• G1/S transition of mitotic cell cycle • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • GTP catabolic process • translational termination • protein methylation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 16:
11.96 – 12.01 Mb

Chr 16:
11.22 – 11.25 Mb

PubMed search

Eukaryotic peptide chain release factor GTP-binding subunit ERF3A is an enzyme that in humans is encoded by the GSPT1 gene.^[1]^[2]^[3]

Interactions

GSPT1 has been shown to interact with BIRC2.^[4]

References

↑ Hoshino S, Miyazawa H, Enomoto T, Hanaoka F, Kikuchi Y, Kikuchi A, Ui M (Jan 1990). "A human homologue of the yeast GST1 gene codes for a GTP-binding protein and is expressed in a proliferation-dependent manner in mammalian cells". EMBO J 8 (12): 3807–14. PMC 402068. PMID 2511002.
↑ Lee JA, Park JE, Lee DH, Park SG, Myung PK, Park BC, Cho S (Feb 2008). "G1 to S phase transition protein 1 induces apoptosis signal-regulating kinase 1 activation by dissociating 14-3-3 from ASK1". Oncogene 27 (9): 1297–305. doi:10.1038/sj.onc.1210740. PMID 17700517.
↑ "Entrez Gene: GSPT1 G1 to S phase transition 1".
↑ Hegde, Ramesh; Srinivasula Srinivasa M, Datta Pinaki, Madesh Muniswamy, Wassell Richard, Zhang ZhiJia, Cheong NaEun, Nejmeh Julie, Fernandes-Alnemri Teresa, Hoshino Shin-ichi, Alnemri Emad S (Oct 2003). "The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein". J. Biol. Chem. (United States) 278 (40): 38699–706. doi:10.1074/jbc.M303179200. ISSN 0021-9258. PMID 12865429.

Ozawa K, Murakami Y, Eki T et al. (1992). "Mapping of the human GSPT1 gene, a human homolog of the yeast GST1 gene, to chromosomal band 16p13.1.". Somat. Cell Mol. Genet. 18 (2): 189–94. doi:10.1007/BF01233164. PMID 1574740.
Kikuchi Y, Shimatake H, Kikuchi A (1988). "A yeast gene required for the G1-to-S transition encodes a protein containing an A-kinase target site and GTPase domain.". EMBO J. 7 (4): 1175–82. PMC 454453. PMID 2841115.
Czaplinski K, Ruiz-Echevarria MJ, Paushkin SV et al. (1998). "The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs.". Genes Dev. 12 (11): 1665–77. doi:10.1101/gad.12.11.1665. PMC 316864. PMID 9620853.
Hoshino S, Imai M, Mizutani M et al. (1998). "Molecular cloning of a novel member of the eukaryotic polypeptide chain-releasing factors (eRF). Its identification as eRF3 interacting with eRF1.". J. Biol. Chem. 273 (35): 22254–9. doi:10.1074/jbc.273.35.22254. PMID 9712840.
Merkulova TI, Frolova LY, Lazar M et al. (1999). "C-terminal domains of human translation termination factors eRF1 and eRF3 mediate their in vivo interaction.". FEBS Lett. 443 (1): 41–7. doi:10.1016/S0014-5793(98)01669-X. PMID 9928949.
Hoshino S, Imai M, Kobayashi T et al. (1999). "The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3'-Poly(A) tail of mRNA. Direct association of erf3/GSPT with polyadenylate-binding protein.". J. Biol. Chem. 274 (24): 16677–80. doi:10.1074/jbc.274.24.16677. PMID 10358005.
Loftus BJ, Kim UJ, Sneddon VP et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.". Genomics 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Cosson B, Berkova N, Couturier A et al. (2003). "Poly(A)-binding protein and eRF3 are associated in vivo in human and Xenopus cells.". Biol. Cell 94 (4-5): 205–16. doi:10.1016/S0248-4900(02)01194-2. PMID 12489690.
Hegde R, Srinivasula SM, Datta P et al. (2003). "The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein.". J. Biol. Chem. 278 (40): 38699–706. doi:10.1074/jbc.M303179200. PMID 12865429.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Janzen DM, Geballe AP (2004). "The effect of eukaryotic release factor depletion on translation termination in human cell lines.". Nucleic Acids Res. 32 (15): 4491–502. doi:10.1093/nar/gkh791. PMC 516063. PMID 15326224.
Le Roy F, Salehzada T, Bisbal C et al. (2005). "A newly discovered function for RNase L in regulating translation termination.". Nat. Struct. Mol. Biol. 12 (6): 505–12. doi:10.1038/nsmb944. PMID 15908960.
Brito M, Malta-Vacas J, Carmona B et al. (2006). "Polyglycine expansions in eRF3/GSPT1 are associated with gastric cancer susceptibility.". Carcinogenesis 26 (12): 2046–9. doi:10.1093/carcin/bgi168. PMID 15987717.
Chauvin C, Salhi S, Le Goff C et al. (2005). "Involvement of human release factors eRF3a and eRF3b in translation termination and regulation of the termination complex formation.". Mol. Cell. Biol. 25 (14): 5801–11. doi:10.1128/MCB.25.14.5801-5811.2005. PMC 1168810. PMID 15987998.
Kashima I, Yamashita A, Izumi N et al. (2006). "Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay.". Genes Dev. 20 (3): 355–67. doi:10.1101/gad.1389006. PMC 1361706. PMID 16452507.
Tompkins V, Hagen J, Zediak VP, Quelle DE (2006). "Identification of novel ARF binding proteins by two-hybrid screening.". Cell Cycle 5 (6): 641–6. PMID 16582619.
Lim J, Hao T, Shaw C et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Chauvin C, Salhi S, Jean-Jean O (2007). "Human eukaryotic release factor 3a depletion causes cell cycle arrest at G1 phase through inhibition of the mTOR pathway.". Mol. Cell. Biol. 27 (16): 5619–29. doi:10.1128/MCB.00035-07. PMC 1952125. PMID 17562865.

GSPT1

Interactions

References

Further reading