GSG2

Germ cell associated 2 (haspin)

Rendering based on PDB 2VUW.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2VUW, 2WB8, 3DLZ, 3E7V, 3F2N, 3FMD, 3IQ7, 4OUC

Identifiers

GSG2 ; HASPIN

External IDs

OMIM: 609240 MGI: 1194498 HomoloGene: 49236 IUPHAR: 2028 ChEMBL: 1075163 GeneCards: GSG2 Gene

Gene ontology
Molecular function	• DNA binding • protein kinase activity • protein binding • ATP binding • histone kinase activity (H3-T3 specific)
Cellular component	• nucleus • chromosome • cytoplasm • centrosome • spindle
Biological process	• protein phosphorylation • mitotic sister chromatid cohesion • intracellular signal transduction • protein localization to chromosome, centromeric region • regulation of spindle checkpoint • negative regulation of G1/S transition of mitotic cell cycle • histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

ENSG00000177602

ENSMUSG00000050107

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 17:
3.63 – 3.63 Mb

Chr 11:
73.14 – 73.14 Mb

PubMed search

Serine/threonine-protein kinase haspin is an enzyme that in humans is encoded by the GSG2 gene.^[1]

References

↑ "Entrez Gene: GSG2 germ cell associated 2 (haspin)".

Further reading

Dai J, Sullivan BA, Higgins JM (2007). "Regulation of mitotic chromosome cohesion by Haspin and Aurora B.". Dev. Cell 11 (5): 741–50. doi:10.1016/j.devcel.2006.09.018. PMID 17084365.
Nousiainen M, Silljé HH, Sauer G et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Dai J, Sultan S, Taylor SS, Higgins JM (2005). "The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment.". Genes Dev. 19 (4): 472–88. doi:10.1101/gad.1267105. PMC 548948. PMID 15681610.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Higgins JM (2001). "The Haspin gene: location in an intron of the integrin alphaE gene, associated transcription of an integrin alphaE-derived RNA and expression in diploid as well as haploid cells.". Gene 267 (1): 55–69. doi:10.1016/S0378-1119(01)00387-0. PMID 11311556.
Tanaka H, Iguchi N, Nakamura Y et al. (2001). "Cloning and characterization of human haspin gene encoding haploid germ cell-specific nuclear protein kinase.". Mol. Hum. Reprod. 7 (3): 211–8. doi:10.1093/molehr/7.3.211. PMID 11228240.