GRINL1A
| Polymerase (RNA) II (DNA directed) polypeptide M | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | POLR2M ; GCOM1; GRINL1A; Gdown; Gdown1 | ||||||||||||
| External IDs | OMIM: 606485 HomoloGene: 9181 GeneCards: POLR2M Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 81488 | 28015 | |||||||||||
| Ensembl | ENSG00000255529 | ENSMUSG00000032199 | |||||||||||
| UniProt | P0CAP1 | Q6P6I6 | |||||||||||
| RefSeq (mRNA) | NM_001018102 | NM_001164793 | |||||||||||
| RefSeq (protein) | NP_001018112 | NP_001158265 | |||||||||||
| Location (UCSC) | Chr 15: 57.88 – 58.07 Mb | Chr 9: 71.48 – 71.49 Mb | |||||||||||
| PubMed search | |||||||||||||
GRINL1A complex locus protein 1 is a protein that in humans is encoded by the GRINL1A gene.[1]
This gene (GRINL1A) is part of a complex transcript unit that includes the gene for GRINL1A combined protein (Gcom1). Transcription of this gene occurs at a downstream promoter, with at least three different alternatively spliced variants, grouped together as Gdown for GRINL1A downstream transcripts. The Gcom1 gene uses an upstream promoter for transcription and also has multiple alternatively spliced variants.[1]
See also
References
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Simpson JC, Wellenreuther R, Poustka A et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
- Roginski RS, Mohan Raj BK, Finkernagel SW, Sciorra LJ (2001). "Assignment of an ionotropic glutamate receptor-like gene (GRINL1A) to human chromosome 15q22.1 by in situ hybridization.". Cytogenet. Cell Genet. 93 (1-2): 143–4. doi:10.1159/000056971. PMID 11474202.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Roginski RS, Mohan Raj BK, Birditt B, Rowen L (2005). "The human GRINL1A gene defines a complex transcription unit, an unusual form of gene organization in eukaryotes.". Genomics 84 (2): 265–76. doi:10.1016/j.ygeno.2004.04.004. PMID 15233991.
- Wiemann S, Arlt D, Huber W et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Mehrle A, Rosenfelder H, Schupp I et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
External links
- GRINL1A protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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