GRIK5

Glutamate receptor, ionotropic, kainate 5
Identifiers
SymbolsGRIK5 ; EAA2; GRIK2; GluK5; KA2
External IDsOMIM: 600283 MGI: 95818 HomoloGene: 1578 IUPHAR: 454 ChEMBL: 2675 GeneCards: GRIK5 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez290114809
EnsemblENSG00000105737ENSMUSG00000003378
UniProtQ16478Q61626
RefSeq (mRNA)NM_001301030NM_008168
RefSeq (protein)NP_001287959NP_032194
Location (UCSC)Chr 19:
42.5 – 42.57 Mb		Chr 7:
25.01 – 25.07 Mb
PubMed search

Glutamate receptor, ionotropic kainate 5 is a protein that in humans is encoded by the GRIK5 gene.[1][2]

Function

This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members.[2]

Interactions

GRIK5 has been shown to interact with DLG4[3][4] and GRIK2.[5][6]

See also

References

  1. ↑ Szpirer C, Molne M, Antonacci R, Jenkins NA, Finelli P, Szpirer J, Riviere M, Rocchi M, Gilbert DJ, Copeland NG et al. (January 1995). "The genes encoding the glutamate receptor subunits KA1 and KA2 (GRIK4 and GRIK5) are located on separate chromosomes in human, mouse, and rat". Proc Natl Acad Sci U S A 91 (25): 11849–53. doi:10.1073/pnas.91.25.11849. PMC 45333. PMID 7527545.
  2. ↑ 2.0 2.1 "Entrez Gene: GRIK5 glutamate receptor, ionotropic, kainate 5".
  3. ↑ Mehta S, Wu H, Garner CC, Marshall J (May 2001). "Molecular mechanisms regulating the differential association of kainate receptor subunits with SAP90/PSD-95 and SAP97". J. Biol. Chem. 276 (19): 16092–9. doi:10.1074/jbc.M100643200. PMID 11279111.
  4. ↑ Garcia EP, Mehta S, Blair LA, Wells DG, Shang J, Fukushima T, Fallon JR, Garner CC, Marshall J (October 1998). "SAP90 binds and clusters kainate receptors causing incomplete desensitization". Neuron 21 (4): 727–39. doi:10.1016/S0896-6273(00)80590-5. PMID 9808460.
  5. ↑ Wenthold RJ, Trumpy VA, Zhu WS, Petralia RS (January 1994). "Biochemical and assembly properties of GluR6 and KA2, two members of the kainate receptor family, determined with subunit-specific antibodies". J. Biol. Chem. 269 (2): 1332–9. PMID 8288598.
  6. ↑ Ripellino JA, Neve RL, Howe JR (January 1998). "Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum". Neuroscience 82 (2): 485–97. doi:10.1016/S0306-4522(97)00296-0. PMID 9466455.

Further reading

  • Kamboj RK, Schoepp DD, Nutt S et al. (1992). "Molecular structure and pharmacological characterization of humEAA2, a novel human kainate receptor subunit.". Mol. Pharmacol. 42 (1): 10–5. PMID 1321949.
  • Cauley K, Kukekov V, Young D (1997). "Kainate/AMPA receptors expressed on human fetal astrocytes in long-term culture.". J. Neurosci. Res. 47 (3): 311–21. doi:10.1002/(SICI)1097-4547(19970201)47:3<311::AID-JNR9>3.0.CO;2-L. PMID 9039653.
  • Porter RH, Eastwood SL, Harrison PJ (1997). "Distribution of kainate receptor subunit mRNAs in human hippocampus, neocortex and cerebellum, and bilateral reduction of hippocampal GluR6 and KA2 transcripts in schizophrenia.". Brain Res. 751 (2): 217–31. doi:10.1016/S0006-8993(96)01404-7. PMID 9099808.
  • Ripellino JA, Neve RL, Howe JR (1998). "Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum.". Neuroscience 82 (2): 485–97. doi:10.1016/S0306-4522(97)00296-0. PMID 9466455.
  • Garcia EP, Mehta S, Blair LA et al. (1998). "SAP90 binds and clusters kainate receptors causing incomplete desensitization.". Neuron 21 (4): 727–39. doi:10.1016/S0896-6273(00)80590-5. PMID 9808460.
  • Mehta S, Wu H, Garner CC, Marshall J (2001). "Molecular mechanisms regulating the differential association of kainate receptor subunits with SAP90/PSD-95 and SAP97.". J. Biol. Chem. 276 (19): 16092–9. doi:10.1074/jbc.M100643200. PMID 11279111.
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Kohda K, Kamiya Y, Matsuda S et al. (2003). "Heteromer formation of delta2 glutamate receptors with AMPA or kainate receptors.". Brain Res. Mol. Brain Res. 110 (1): 27–37. doi:10.1016/S0169-328X(02)00561-2. PMID 12573530.
  • Hayes DM, Braud S, Hurtado DE et al. (2003). "Trafficking and surface expression of the glutamate receptor subunit, KA2.". Biochem. Biophys. Res. Commun. 310 (1): 8–13. doi:10.1016/j.bbrc.2003.08.115. PMID 14511640.
  • Kamm C, Leung J, Joseph S et al. (2004). "Refined linkage to the RDP/DYT12 locus on 19q13.2 and evaluation of GRIK5 as a candidate gene.". Mov. Disord. 19 (7): 845–7. doi:10.1002/mds.20095. PMID 15254951.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.