GRID1
| Glutamate receptor, ionotropic, delta 1 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | GRID1 ; GluD1 | ||||||||||||
| External IDs | OMIM: 610659 MGI: 95812 HomoloGene: 69017 IUPHAR: 448 ChEMBL: 2936 GeneCards: GRID1 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 2894 | 14803 | |||||||||||
| Ensembl | ENSG00000182771 | ENSMUSG00000041078 | |||||||||||
| UniProt | Q9ULK0 | Q61627 | |||||||||||
| RefSeq (mRNA) | NM_017551 | NM_008166 | |||||||||||
| RefSeq (protein) | NP_060021 | NP_032192 | |||||||||||
| Location (UCSC) | Chr 10: 87.36 – 88.13 Mb | Chr 14: 34.82 – 35.58 Mb | |||||||||||
| PubMed search | |||||||||||||
Glutamate receptor delta-1 subunit also known as GluD1 or GluRδ1 is a protein[1][2] that in humans is encoded by the GRID1 gene.[3][4]
Function
This gene encodes a subunit of glutamate receptor ligand-gated ion channel. These channels mediate most of the fast excitatory synaptic transmission in the central nervous system and play key roles in synaptic plasticity.[3]
Clinical significance
Several genetic epidemiology studies have shown a strong association between several variants of the GRID1 gene and increased risk of developing schizophrenia.[5][6]
See also
References
- ↑ Yamazaki M, Araki K, Shibata A, Mishina M (March 1992). "Molecular cloning of a cDNA encoding a novel member of the mouse glutamate receptor channel family". Biochem. Biophys. Res. Commun. 183 (2): 886–92. doi:10.1016/0006-291X(92)90566-4. PMID 1372507.
- ↑ Treadaway J, Zuo J (December 1998). "Mapping of the mouse glutamate receptor delta1 subunit (Grid1) to chromosome 14". Genomics 54 (2): 359–60. doi:10.1006/geno.1998.5599. PMID 9828146.
- ↑ 3.0 3.1 "Entrez Gene: GRID1 glutamate receptor, ionotropic, delta 1".
- ↑ Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (October 1999). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
- ↑ Guo SZ, Huang K, Shi YY, Tang W, Zhou J, Feng GY, Zhu SM, Liu HJ, Chen Y, Sun XD, He L (July 2007). "A case-control association study between the GRID1 gene and schizophrenia in the Chinese Northern Han population". Schizophr. Res. 93 (1–3): 385–90. doi:10.1016/j.schres.2007.03.007. PMID 17490860.
- ↑ Treutlein J, Mühleisen TW, Frank J, Mattheisen M, Herms S, Ludwig KU, Treutlein T, Schmael C, Strohmaier J, Bösshenz KV, Breuer R, Paul T, Witt SH, Schulze TG, Schlösser RG, Nenadic I, Sauer H, Becker T, Maier W, Cichon S, Nöthen MM, Rietschel M (June 2009). "Dissection of phenotype reveals possible association between schizophrenia and Glutamate Receptor Delta 1 (GRID1) gene promoter". Schizophr. Res. 111 (1–3): 123–30. doi:10.1016/j.schres.2009.03.011. PMID 19346103.
Further reading
- Fallin MD; Lasseter VK; Avramopoulos D et al. (2006). "Bipolar I Disorder and Schizophrenia: A 440–Single-Nucleotide Polymorphism Screen of 64 Candidate Genes among Ashkenazi Jewish Case-Parent Trios". Am. J. Hum. Genet. 77 (6): 918–36. doi:10.1086/497703. PMC 1285177. PMID 16380905.
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Yue Z; Horton A; Bravin M et al. (2002). "A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice". Neuron 35 (5): 921–33. doi:10.1016/S0896-6273(02)00861-9. PMID 12372286.
- Ly CD, Roche KW, Lee HK, Wenthold RJ (2002). "Identification of rat EMAP, a delta-glutamate receptor binding protein". Biochem. Biophys. Res. Commun. 291 (1): 85–90. doi:10.1006/bbrc.2002.6413. PMID 11829466.
- Roche KW; Ly CD; Petralia RS et al. (1999). "Postsynaptic density-93 interacts with the delta2 glutamate receptor subunit at parallel fiber synapses". J. Neurosci. 19 (10): 3926–34. PMID 10234023.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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