GRAP
| GRB2-related adaptor protein | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | GRAP ; MGC64880 | ||||||||||||
| External IDs | OMIM: 604330 MGI: 1918770 HomoloGene: 4822 GeneCards: GRAP Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 10750 | 71520 | |||||||||||
| Ensembl | ENSG00000154016 | ENSMUSG00000004837 | |||||||||||
| UniProt | Q13588 | Q9CX99 | |||||||||||
| RefSeq (mRNA) | NM_006613 | NM_027817 | |||||||||||
| RefSeq (protein) | NP_006604 | NP_082093 | |||||||||||
| Location (UCSC) | Chr 17: 18.92 – 18.95 Mb | Chr 11: 61.65 – 61.67 Mb | |||||||||||
| PubMed search | |||||||||||||
GRB2-related adapter protein is a protein that in humans is encoded by the GRAP gene.[1][2][3]
This gene encodes a member of the GRB2/Sem5 (C. elegans homolog)/Drk (Drosophila homolog) family. This member functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain.[3]
Interactions
GRAP has been shown to interact with Linker of activated T cells.[4][5]
References
- ↑ Feng GS, Ouyang YB, Hu DP, Shi ZQ, Gentz R, Ni J (Jul 1996). "Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway". J Biol Chem 271 (21): 12129–32. doi:10.1074/jbc.271.21.12129. PMID 8647802.
- ↑ Trub T, Frantz JD, Miyazaki M, Band H, Shoelson SE (Feb 1997). "The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling". J Biol Chem 272 (2): 894–902. doi:10.1074/jbc.272.2.894. PMID 8995379.
- ↑ 3.0 3.1 "Entrez Gene: GRAP GRB2-related adaptor protein".
- ↑ Zhang, W; Sloan-Lancaster J; Kitchen J; Trible R P; Samelson L E (Jan 1998). "LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation". Cell (UNITED STATES) 92 (1): 83–92. doi:10.1016/S0092-8674(00)80901-0. ISSN 0092-8674. PMID 9489702.
- ↑ Perez-Villar, Juan J; Whitney Gena S, Sitnick Mitchell T, Dunn Robert J, Venkatesan Srividhya, O'Day Kathleen, Schieven Gary L, Lin Tai-An, Kanner Steven B (Aug 2002). "Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav". Biochemistry (United States) 41 (34): 10732–40. doi:10.1021/bi025554o. ISSN 0006-2960. PMID 12186560.
Further reading
- Welsh M, Songyang Z, Frantz JD et al. (1998). "Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins.". Oncogene 16 (7): 891–901. doi:10.1038/sj.onc.1201607. PMID 9484780.
- Zhang W, Sloan-Lancaster J, Kitchen J et al. (1998). "LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation.". Cell 92 (1): 83–92. doi:10.1016/S0092-8674(00)80901-0. PMID 9489702.
- Wenzel J, Sanzenbacher R, Ghadimi M et al. (2002). "Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor.". FEBS Lett. 509 (2): 255–62. doi:10.1016/S0014-5793(01)03174-X. PMID 11741599.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Zhao C, Ma H, Bossy-Wetzel E et al. (2003). "GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2.". J. Biol. Chem. 278 (36): 34641–53. doi:10.1074/jbc.M304594200. PMID 12819203.
- Shiraiwa H, Takei M, Yoshikawa T et al. (2004). "Detection of Grb-2-related adaptor protein gene (GRAP) and peptide molecule in salivary glands of MRL/lpr mice and patients with Sjögren's syndrome.". J. Int. Med. Res. 32 (3): 284–91. doi:10.1177/147323000403200308. PMID 15174222.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.