GPX6
| Glutathione peroxidase 6 (olfactory) | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | GPX6 ; GPX5p; GPXP3; GPx-6; GSHPx-6; dJ1186N24; dJ1186N24.1 | ||||||||||||
| External IDs | OMIM: 607913 MGI: 1922762 HomoloGene: 130008 GeneCards: GPX6 Gene | ||||||||||||
| EC number | 1.11.1.9 | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 257202 | 75512 | |||||||||||
| Ensembl | ENSG00000198704 | ENSMUSG00000004341 | |||||||||||
| UniProt | P59796 | Q91WR8 | |||||||||||
| RefSeq (mRNA) | NM_182701 | NM_145451 | |||||||||||
| RefSeq (protein) | NP_874360 | NP_663426 | |||||||||||
| Location (UCSC) | Chr 6: 28.47 – 28.5 Mb | Chr 13: 21.31 – 21.32 Mb | |||||||||||
| PubMed search | |||||||||||||
Glutathione peroxidase 6 (GPx-6) is an enzyme that in humans is encoded by the GPX6 gene.[1][2]
This gene product belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Expression of this gene is restricted to embryos and adult olfactory epithelium.[1]
References
- ↑ 1.0 1.1 "Entrez Gene: glutathione peroxidase 6 (olfactory)".
- ↑ Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigó R, Gladyshev VN (May 2003). "Characterization of mammalian selenoproteomes". Science 300 (5624): 1439–43. doi:10.1126/science.1083516. PMID 12775843.
Further reading
- Talmud PJ, Drenos F, Shah S et al. (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
- Richard MJ, Guiraud P, Didier C et al. (2001). "Human immunodeficiency virus type 1 Tat protein impairs selenoglutathione peroxidase expression and activity by a mechanism independent of cellular selenium uptake: consequences on cellular resistance to UV-A radiation.". Arch. Biochem. Biophys. 386 (2): 213–20. doi:10.1006/abbi.2000.2197. PMID 11368344.
- Opalenik SR, Ding Q, Mallery SR, Thompson JA (1998). "Glutathione depletion associated with the HIV-1 TAT protein mediates the extracellular appearance of acidic fibroblast growth factor.". Arch. Biochem. Biophys. 351 (1): 17–26. doi:10.1006/abbi.1997.0566. PMID 9501919.
- Choi J, Liu RM, Kundu RK et al. (2000). "Molecular mechanism of decreased glutathione content in human immunodeficiency virus type 1 Tat-transgenic mice.". J. Biol. Chem. 275 (5): 3693–8. doi:10.1074/jbc.275.5.3693. PMID 10652368.
- Strausberg RL, Feingold EA, Grouse LH et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Price TO, Ercal N, Nakaoke R, Banks WA (2005). "HIV-1 viral proteins gp120 and Tat induce oxidative stress in brain endothelial cells.". Brain Res. 1045 (1-2): 57–63. doi:10.1016/j.brainres.2005.03.031. PMID 15910762.
- Bailey SD, Xie C, Do R et al. (2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.". Diabetes Care 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168. PMID 20628086.
- Moyer AM, Sun Z, Batzler AJ et al. (2010). "Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy.". Cancer Epidemiol. Biomarkers Prev. 19 (3): 811–21. doi:10.1158/1055-9965.EPI-09-0871. PMC 2837367. PMID 20200426.
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