GPX3
| Glutathione peroxidase 3 (plasma) | |||||||||||||
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 PDB rendering based on 2r37. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | GPX3 ; GPx-P; GSHPx-3; GSHPx-P | ||||||||||||
| External IDs | OMIM: 138321 MGI: 105102 HomoloGene: 20480 GeneCards: GPX3 Gene | ||||||||||||
| EC number | 1.11.1.9 | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 2878 | 14778 | |||||||||||
| Ensembl | ENSG00000211445 | ENSMUSG00000018339 | |||||||||||
| UniProt | P22352 | P46412 | |||||||||||
| RefSeq (mRNA) | NM_002084 | NM_001083929 | |||||||||||
| RefSeq (protein) | NP_002075 | NP_032187 | |||||||||||
| Location (UCSC) | Chr 5: 150.4 – 150.41 Mb | Chr 11: 54.72 – 54.72 Mb | |||||||||||
| PubMed search | |||||||||||||
Glutathione peroxidase 3 (GPx-3), also known as plasma glutathione peroxidase (GPx-P) or extracellular glutathione peroxidase is an enzyme that in humans is encoded by the GPX3 gene.[1][2][3]
GPx-3belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.[1]
References
- ↑ 1.0 1.1 "Entrez Gene: glutathione peroxidase 3 (plasma)".
- ↑ Takahashi K, Avissar N, Whitin J, Cohen H (August 1987). "Purification and characterization of human plasma glutathione peroxidase: a selenoglycoprotein distinct from the known cellular enzyme". Arch. Biochem. Biophys. 256 (2): 677–86. doi:10.1016/0003-9861(87)90624-2. PMID 3619451.
- ↑ Chu FF (1994). "The human glutathione peroxidase genes GPX2, GPX3, and GPX4 map to chromosomes 14, 5, and 19, respectively". Cytogenet. Cell Genet. 66 (2): 96–8. doi:10.1159/000133675. PMID 8287691.
Further reading
- Guey LT, García-Closas M, Murta-Nascimento C et al. (2010). "Genetic susceptibility to distinct bladder cancer subphenotypes.". Eur. Urol. 57 (2): 283–92. doi:10.1016/j.eururo.2009.08.001. PMC 3220186. PMID 19692168.
- Lin JC, Kuo WR, Chiang FY et al. (2009). "Glutathione peroxidase 3 gene polymorphisms and risk of differentiated thyroid cancer.". Surgery 145 (5): 508–13. doi:10.1016/j.surg.2008.12.008. PMID 19375609.
- Holtzman JL (2002). "The role of low levels of the serum glutathione-dependent peroxidase and glutathione and high levels of serum homocysteine in the development of cardiovascular disease.". Clin. Lab. 48 (3-4): 129–30. PMID 11934214.
- Fullerton JM, Tiwari Y, Agahi G et al. (2010). "Assessing oxidative pathway genes as risk factors for bipolar disorder.". Bipolar Disord 12 (5): 550–6. doi:10.1111/j.1399-5618.2010.00834.x. PMID 20712757.
- Hosgood HD, Zhang L, Shen M et al. (2009). "Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.". Occup Environ Med 66 (12): 848–53. doi:10.1136/oem.2008.044024. PMC 2928224. PMID 19773279.
- Liang XS, Caporaso N, McMaster ML et al. (2009). "Common genetic variants in candidate genes and risk of familial lymphoid malignancies.". Br. J. Haematol. 146 (4): 418–23. doi:10.1111/j.1365-2141.2009.07790.x. PMC 2890251. PMID 19573080.
- Hosgood HD, Menashe I, He X et al. (2009). "PTEN identified as important risk factor of chronic obstructive pulmonary disease.". Respir Med 103 (12): 1866–70. doi:10.1016/j.rmed.2009.06.016. PMC 2783799. PMID 19625176.
- Mistry HD, Kurlak LO, Williams PJ et al. (2010). "Differential expression and distribution of placental glutathione peroxidases 1, 3 and 4 in normal and preeclamptic pregnancy.". Placenta 31 (5): 401–8. doi:10.1016/j.placenta.2010.02.011. PMID 20303587.
- Hosgood HD, Menashe I, Shen M et al. (2008). "Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.". Carcinogenesis 29 (10): 1938–43. doi:10.1093/carcin/bgn178. PMC 2722857. PMID 18676680.
- Iida R, Tsubota E, Yuasa I et al. (2009). "Simultaneous genotyping of 11 non-synonymous SNPs in the 4 glutathione peroxidase genes using the multiplex single base extension method.". Clin. Chim. Acta 402 (1-2): 79–82. doi:10.1016/j.cca.2008.12.027. PMID 19161995.
- Talmud PJ, Drenos F, Shah S et al. (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
- Wang JY, Yang IP, Wu DC et al. (2010). "Functional glutathione peroxidase 3 polymorphisms associated with increased risk of Taiwanese patients with gastric cancer.". Clin. Chim. Acta 411 (19-20): 1432–6. doi:10.1016/j.cca.2010.05.026. PMID 20576521.
- Westphal K, Stangl V, Fähling M et al. (2009). "Human-specific induction of glutathione peroxidase-3 by proteasome inhibition in cardiovascular cells.". Free Radic. Biol. Med. 47 (11): 1652–60. doi:10.1016/j.freeradbiomed.2009.09.017. PMID 19766714.
- Shen M, Vermeulen R, Rajaraman P et al. (2009). "Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.". Environ. Mol. Mutagen. 50 (4): 285–90. doi:10.1002/em.20452. PMC 2666781. PMID 19170196.
- Saga Y, Ohwada M, Suzuki M et al. (2008). "Glutathione peroxidase 3 is a candidate mechanism of anticancer drug resistance of ovarian clear cell adenocarcinoma.". Oncol. Rep. 20 (6): 1299–303. PMID 19020706.
- Zhang X, Yang JJ, Kim YS et al. (2010). "An 8-gene signature, including methylated and down-regulated glutathione peroxidase 3, of gastric cancer.". Int. J. Oncol. 36 (2): 405–14. doi:10.3892/ijo_00000513. PMID 20043075.
- Chung SS, Kim M, Youn BS et al. (2009). "Glutathione peroxidase 3 mediates the antioxidant effect of peroxisome proliferator-activated receptor gamma in human skeletal muscle cells.". Mol. Cell. Biol. 29 (1): 20–30. doi:10.1128/MCB.00544-08. PMC 2612482. PMID 18936159.
- Wang Y, Fu W, Xie F et al. (2010). "Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population.". J. Hum. Genet. 55 (8): 490–4. doi:10.1038/jhg.2010.53. PMID 20485444.
- Moyer AM, Sun Z, Batzler AJ et al. (2010). "Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy.". Cancer Epidemiol. Biomarkers Prev. 19 (3): 811–21. doi:10.1158/1055-9965.EPI-09-0871. PMC 2837367. PMID 20200426.
- Bailey SD, Xie C, Do R et al. (2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.". Diabetes Care 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168. PMID 20628086.
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