GNB2L1

Guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsGNB2L1 ; Gnb2-rs1; H12.3; HLC-7; PIG21; RACK1
External IDsOMIM: 176981 MGI: 101849 HomoloGene: 4446 GeneCards: GNB2L1 Gene
Orthologs
SpeciesHumanMouse
Entrez1039914694
EnsemblENSG00000204628ENSMUSG00000020372
UniProtP63244P68040
RefSeq (mRNA)NM_006098NM_008143
RefSeq (protein)NP_006089NP_032169
Location (UCSC)Chr 5:
180.66 – 180.68 Mb		Chr 11:
48.8 – 48.81 Mb
PubMed search

Guanine nucleotide-binding protein subunit beta-2-like 1, also known as Receptor for activated C kinase 1 (RACK1) is a 32 kDa protein that in humans is encoded by the GNB2L1 gene.[1][2]

Interactions

GNB2L1 has been shown to interact with:

See also

References

  1. ↑ Ron D, Chen CH, Caldwell J, Jamieson L, Orr E, Mochly-Rosen D (March 1994). "Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins". Proc Natl Acad Sci U S A 91 (3): 839–43. doi:10.1073/pnas.91.3.839. PMC 521407. PMID 8302854.
  2. ↑ Guillemot F, Billault A, Auffray C (July 1989). "Physical linkage of a guanine nucleotide-binding protein-related gene to the chicken major histocompatibility complex". Proc Natl Acad Sci U S A 86 (12): 4594–8. doi:10.1073/pnas.86.12.4594. PMC 287317. PMID 2499885.
  3. ↑ Yarwood, S J; Steele M R; Scotland G; Houslay M D; Bolger G B (May 1999). "The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform". J. Biol. Chem. (UNITED STATES) 274 (21): 14909–17. doi:10.1074/jbc.274.21.14909. ISSN 0021-9258. PMID 10329691.
  4. ↑ Steele, M R; McCahill A; Thompson D S; MacKenzie C; Isaacs N W; Houslay M D; Bolger G B (July 2001). "Identification of a surface on the beta-propeller protein RACK1 that interacts with the cAMP-specific phosphodiesterase PDE4D5". Cell. Signal. (England) 13 (7): 507–13. doi:10.1016/S0898-6568(01)00167-X. ISSN 0898-6568. PMID 11516626.
  5. ↑ 5.0 5.1 5.2 Usacheva, Anna; Tian Xinyong; Sandoval Raudel; Salvi Debra; Levy David; Colamonici Oscar R (September 2003). "The WD motif-containing protein RACK-1 functions as a scaffold protein within the type I IFN receptor-signaling complex". J. Immunol. (United States) 171 (6): 2989–94. doi:10.4049/jimmunol.171.6.2989. ISSN 0022-1767. PMID 12960323.
  6. ↑ 6.0 6.1 Usacheva, A; Smith R; Minshall R; Baida G; Seng S; Croze E; Colamonici O (June 2001). "The WD motif-containing protein receptor for activated protein kinase C (RACK1) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor". J. Biol. Chem. (United States) 276 (25): 22948–53. doi:10.1074/jbc.M100087200. ISSN 0021-9258. PMID 11301323.
  7. ↑ Chang, B Y; Conroy K B; Machleder E M; Cartwright C A (June 1998). "RACK1, a receptor for activated C kinase and a homolog of the beta subunit of G proteins, inhibits activity of src tyrosine kinases and growth of NIH 3T3 cells". Mol. Cell. Biol. (UNITED STATES) 18 (6): 3245–56. ISSN 0270-7306. PMC 108906. PMID 9584165.
  8. ↑ Rigas, Anastasia C; Ozanne Daniel M; Neal David E; Robson Craig N (November 2003). "The scaffolding protein RACK1 interacts with androgen receptor and promotes cross-talk through a protein kinase C signaling pathway". J. Biol. Chem. (United States) 278 (46): 46087–93. doi:10.1074/jbc.M306219200. ISSN 0021-9258. PMID 12958311.
  9. ↑ Wang, Wei; Huang Yan, Zhou Zongxiang, Tang Rong, Zhao Wei, Zeng Li, Xu Ming, Cheng Chao, Gu Shaohua, Ying Kang, Xie Yi, Mao Yumin (January 2002). "Identification and characterization of AGTRAP, a human homolog of murine Angiotensin II Receptor-Associated Protein (Agtrap)". Int. J. Biochem. Cell Biol. (England) 34 (1): 93–102. doi:10.1016/S1357-2725(01)00094-2. ISSN 1357-2725. PMID 11733189.
  10. ↑ Yaka, Rami; He Dao-Yao; Phamluong Khanhky; Ron Dorit (March 2003). "Pituitary adenylate cyclase-activating polypeptide (PACAP(1-38)) enhances N-methyl-D-aspartate receptor function and brain-derived neurotrophic factor expression via RACK1". J. Biol. Chem. (United States) 278 (11): 9630–8. doi:10.1074/jbc.M209141200. ISSN 0021-9258. PMID 12524444.
  11. ↑ Yaka, Rami; Thornton Claire; Vagts Alicia J; Phamluong Khanhky; Bonci Antonello; Ron Dorit (April 2002). "NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (8): 5710–5. doi:10.1073/pnas.062046299. ISSN 0027-8424. PMC 122836. PMID 11943848.
  12. ↑ Diederichs, Sven; Bäumer Nicole, Ji Ping, Metzelder Stephan K, Idos Gregory E, Cauvet Thomas, Wang Wenbing, Möller Maria, Pierschalski Sarah, Gromoll Jörg, Schrader Mark G, Koeffler H Phillip, Berdel Wolfgang E, Serve Hubert, Müller-Tidow Carsten (August 2004). "Identification of interaction partners and substrates of the cyclin A1-CDK2 complex". J. Biol. Chem. (United States) 279 (32): 33727–41. doi:10.1074/jbc.M401708200. ISSN 0021-9258. PMID 15159402.
  13. ↑ Croze, E; Usacheva A; Asarnow D; Minshall R D; Perez H D; Colamonici O (November 2000). "Receptor for activated C-kinase (RACK-1), a WD motif-containing protein, specifically associates with the human type I IFN receptor". J. Immunol. (UNITED STATES) 165 (9): 5127–32. doi:10.4049/jimmunol.165.9.5127. ISSN 0022-1767. PMID 11046044.
  14. ↑ Liedtke, Carole M; Yun C H Chris; Kyle Nicole; Wang Dandan (June 2002). "Protein kinase C epsilon-dependent regulation of cystic fibrosis transmembrane regulator involves binding to a receptor for activated C kinase (RACK1) and RACK1 binding to Na+/H+ exchange regulatory factor". J. Biol. Chem. (United States) 277 (25): 22925–33. doi:10.1074/jbc.M201917200. ISSN 0021-9258. PMID 11956211.
  15. ↑ Ozaki, Toshinori; Watanabe Ken-ichi; Nakagawa Takahito; Miyazaki Kou; Takahashi Masato; Nakagawara Akira (May 2003). "Function of p73, not of p53, is inhibited by the physical interaction with RACK1 and its inhibitory effect is counteracted by pRB". Oncogene (England) 22 (21): 3231–42. doi:10.1038/sj.onc.1206382. ISSN 0950-9232. PMID 12761493.
  16. ↑ Koehler, J A; Moran M F (May 2001). "RACK1, a protein kinase C scaffolding protein, interacts with the PH domain of p120GAP". Biochem. Biophys. Res. Commun. (United States) 283 (4): 888–95. doi:10.1006/bbrc.2001.4889. ISSN 0006-291X. PMID 11350068.
  17. ↑ Ron, D; Jiang Z; Yao L; Vagts A; Diamond I; Gordon A (September 1999). "Coordinated movement of RACK1 with activated betaIIPKC". J. Biol. Chem. (UNITED STATES) 274 (38): 27039–46. doi:10.1074/jbc.274.38.27039. ISSN 0021-9258. PMID 10480917.
  18. ↑ Battle, Michele A; Maher Veronica M; McCormick J Justin (June 2003). "ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways". Biochemistry (United States) 42 (24): 7270–82. doi:10.1021/bi034081y. ISSN 0006-2960. PMID 12809483.
  19. ↑ Hellberg, Carina B; Burden-Gulley Susan M, Pietz Gregory E, Brady-Kalnay Susann M (March 2002). "Expression of the receptor protein-tyrosine phosphatase, PTPmu, restores E-cadherin-dependent adhesion in human prostate carcinoma cells". J. Biol. Chem. (United States) 277 (13): 11165–73. doi:10.1074/jbc.M112157200. ISSN 0021-9258. PMID 11801604.
  20. ↑ Mourton, T; Hellberg C B; Burden-Gulley S M; Hinman J; Rhee A; Brady-Kalnay S M (May 2001). "The PTPmu protein-tyrosine phosphatase binds and recruits the scaffolding protein RACK1 to cell-cell contacts". J. Biol. Chem. (United States) 276 (18): 14896–901. doi:10.1074/jbc.M010823200. ISSN 0021-9258. PMID 11278757.
  21. ↑ Ceci, Marcello; Gaviraghi Cristina; Gorrini Chiara; Sala Leonardo A; Offenhäuser Nina; Marchisio Pier Carlo; Biffo Stefano (December 2003). "Release of eIF6 (p27BBP) from the 1960s subunit allows 1980s ribosome assembly". Nature (England) 426 (6966): 579–84. doi:10.1038/nature02160. PMID 14654845.
  22. ↑ Edelmann, Mariola J; Iphöfer Alexander, Akutsu Masato, Altun Mikael, di Gleria Katalin, Kramer Holger B, Fiebiger Edda, Dhe-Paganon Sirano, Kessler Benedikt M (March 2009). "Structural basis and specificity of human otubain 1-mediated deubiquitination". Biochem. J. (England) 418 (2): 379–90. doi:10.1042/BJ20081318. PMID 18954305.
  23. ↑ 23.0 23.1 Liliental, J; Chang D D (January 1998). "Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit". J. Biol. Chem. (UNITED STATES) 273 (4): 2379–83. doi:10.1074/jbc.273.4.2379. ISSN 0021-9258. PMID 9442085.
  24. ↑ Lee, H-S; Millward-Sadler S J; Wright M O; Nuki G; Al-Jamal R; Salter D M (November 2002). "Activation of Integrin-RACK1/PKCalpha signalling in human articular chondrocyte mechanotransduction". Osteoarthr. Cartil. (England) 10 (11): 890–7. doi:10.1053/joca.2002.0842. ISSN 1063-4584. PMID 12435334.

Further reading