GNAI1

Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1

PDB rendering based on 1agr.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1KJY, 1Y3A, 2G83, 2GTP, 2IK8, 2OM2, 2PZ3, 2XNS, 3ONW, 3QE0, 3QI2, 3UMR, 3UMS, 4G5Q

Identifiers

Symbols

GNAI1 ; Gi

External IDs

OMIM: 139310 MGI: 95771 HomoloGene: 74417 ChEMBL: 4741 GeneCards: GNAI1 Gene

Gene ontology
Molecular function	• GTPase activity • signal transducer activity • protein binding • GTP binding • G-protein beta/gamma-subunit complex binding • G-protein coupled serotonin receptor binding • metal ion binding
Cellular component	• nucleus • cytoplasm • lysosomal membrane • centrosome • heterotrimeric G-protein complex • plasma membrane • midbody • extracellular vesicular exosome
Biological process	• GTP catabolic process • cell cycle • G-protein coupled receptor signaling pathway • adenylate cyclase-modulating G-protein coupled receptor signaling pathway • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway • synaptic transmission • blood coagulation • platelet activation • response to peptide hormone • cell division
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 7:
79.76 – 79.85 Mb

Chr 5:
18.27 – 18.36 Mb

PubMed search

Guanine nucleotide-binding protein G(i), alpha-1 subunit is a protein that in humans is encoded by the GNAI1 gene.^[1]^[2]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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|{{{bSize}}}px|alt=Nicotine Activity on Dopaminergic Neurons edit|]]

Nicotine Activity on Dopaminergic Neurons edit

↑ The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602".

Interactions

GNAI1 has been shown to interact with:

References

↑ Bray P, Carter A, Guo V, Puckett C, Kamholz J, Spiegel A et al. (Aug 1987). "Human cDNA clones for an alpha subunit of Gi signal-transduction protein". Proceedings of the National Academy of Sciences of the United States of America 84 (15): 5115–9. doi:10.1073/pnas.84.15.5115. PMC 298804. PMID 3110783.
↑ "Entrez Gene: GNAI1 Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1".
↑ Schiaffino MV, d'Addio M, Alloni A, Baschirotto C, Valetti C, Cortese K et al. (Sep 1999). "Ocular albinism: evidence for a defect in an intracellular signal transduction system". Nature Genetics 23 (1): 108–12. doi:10.1038/12715. PMID 10471510.
↑ 4.0 4.1 Kimple RJ, De Vries L, Tronchère H, Behe CI, Morris RA, Gist Farquhar M et al. (Aug 2001). "RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity". The Journal of Biological Chemistry 276 (31): 29275–81. doi:10.1074/jbc.M103208200. PMID 11387333.
↑ Kimple RJ, Kimple ME, Betts L, Sondek J, Siderovski DP (Apr 2002). "Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits". Nature 416 (6883): 878–81. doi:10.1038/416878a. PMID 11976690.
↑ Woulfe DS, Stadel JM (Jun 1999). "Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP". The Journal of Biological Chemistry 274 (25): 17718–24. doi:10.1074/jbc.274.25.17718. PMID 10364213.
↑ De Vries L, Elenko E, Hubler L, Jones TL, Farquhar MG (Dec 1996). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits". Proceedings of the National Academy of Sciences of the United States of America 93 (26): 15203–8. doi:10.1073/pnas.93.26.15203. PMC 26381. PMID 8986788.
↑ Tall GG, Krumins AM, Gilman AG (Mar 2003). "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor". The Journal of Biological Chemistry 278 (10): 8356–62. doi:10.1074/jbc.M211862200. PMID 12509430.
↑ Lee MJ, Evans M, Hla T (May 1996). "The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway". The Journal of Biological Chemistry 271 (19): 11272–9. doi:10.1074/jbc.271.19.11272. PMID 8626678.

Sidhu A, Niznik HB (Nov 2000). "Coupling of dopamine receptor subtypes to multiple and diverse G proteins". International Journal of Developmental Neuroscience : The Official Journal of the International Society for Developmental Neuroscience 18 (7): 669–77. doi:10.1016/S0736-5748(00)00033-2. PMID 10978845. CS1 maint: Date and year (link)
Brown EJ, Frazier WA (Mar 2001). "Integrin-associated protein (CD47) and its ligands". Trends in Cell Biology 11 (3): 130–5. doi:10.1016/S0962-8924(00)01906-1. PMID 11306274. CS1 maint: Date and year (link)
Raymond JR, Mukhin YV, Gelasco A, Turner J, Collinsworth G, Gettys TW et al. (2002). "Multiplicity of mechanisms of serotonin receptor signal transduction". Pharmacology & Therapeutics 92 (2-3): 179–212. doi:10.1016/S0163-7258(01)00169-3. PMID 11916537.
Jiang M, Pandey S, Tran VT, Fong HK (May 1991). "Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells". Proceedings of the National Academy of Sciences of the United States of America 88 (9): 3907–11. doi:10.1073/pnas.88.9.3907. PMC 51562. PMID 1902575. CS1 maint: Date and year (link)
Gennity JM, Siess W (Nov 1991). "Thrombin inhibits the pertussis-toxin-dependent ADP-ribosylation of a novel soluble Gi-protein in human platelets". The Biochemical Journal. 279 ( Pt 3) (Pt 3): 643–50. PMC 1151493. PMID 1953657. CS1 maint: Date and year (link)
Itoh H, Toyama R, Kozasa T, Tsukamoto T, Matsuoka M, Kaziro Y (May 1988). "Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs". The Journal of Biological Chemistry 263 (14): 6656–64. PMID 2834384. CS1 maint: Date and year (link)
Bloch DB, Bloch KD, Iannuzzi M, Collins FS, Neer EJ, Seidman JG et al. (Jun 1988). "The gene for the alpha i1 subunit of human guanine nucleotide binding protein maps near the cystic fibrosis locus". American Journal of Human Genetics 42 (6): 884–8. PMC 1715192. PMID 3130752. CS1 maint: Date and year (link)
Nagata K, Katada T, Tohkin M, Itoh H, Kaziro Y, Ui M et al. (Sep 1988). "GTP-binding proteins in human platelet membranes serving as the specific substrate of islet-activating protein, pertussis toxin". FEBS Letters 237 (1-2): 113–7. doi:10.1016/0014-5793(88)80182-0. PMID 3139448. CS1 maint: Date and year (link)
Kagimoto S, Yamada Y, Kubota A, Someya Y, Ihara Y, Yasuda K et al. (Jul 1994). "Human somatostatin receptor, SSTR2, is coupled to adenylyl cyclase in the presence of Gi alpha 1 protein". Biochemical and Biophysical Research Communications 202 (2): 1188–95. doi:10.1006/bbrc.1994.2054. PMID 7914078. CS1 maint: Date and year (link)
Nitta K, Uchida K, Kawashima A, Tsutsui T, Ozu H, Naito T et al. (Jan 1994). "Identification of GTP-binding proteins in human glomeruli". Nihon Jinzo Gakkai Shi 36 (1): 9–12. PMID 8107314. CS1 maint: Date and year (link)
Law SF, Zaina S, Sweet R, Yasuda K, Bell GI, Stadel J et al. (Apr 1994). "Gi alpha 1 selectively couples somatostatin receptor subtype 3 to adenylyl cyclase: identification of the functional domains of this alpha subunit necessary for mediating the inhibition by somatostatin of cAMP formation". Molecular Pharmacology 45 (4): 587–90. PMID 8183236. CS1 maint: Date and year (link)
Europe-Finner GN, Phaneuf S, Watson SP, López Bernal A (Jun 1993). "Identification and expression of G-proteins in human myometrium: up-regulation of G alpha s in pregnancy". Endocrinology 132 (6): 2484–90. doi:10.1210/en.132.6.2484. PMID 8504751. CS1 maint: Date and year (link)
Laugwitz KL, Allgeier A, Offermanns S, Spicher K, Van Sande J, Dumont JE et al. (Jan 1996). "The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families". Proceedings of the National Academy of Sciences of the United States of America 93 (1): 116–20. doi:10.1073/pnas.93.1.116. PMC 40189. PMID 8552586. CS1 maint: Date and year (link)
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474. CS1 maint: Date and year (link)
Lee MJ, Evans M, Hla T (May 1996). "The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway". The Journal of Biological Chemistry 271 (19): 11272–9. doi:10.1074/jbc.271.19.11272. PMID 8626678. CS1 maint: Date and year (link)
De Vries L, Elenko E, Hubler L, Jones TL, Farquhar MG (Dec 1996). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits". Proceedings of the National Academy of Sciences of the United States of America 93 (26): 15203–8. doi:10.1073/pnas.93.26.15203. PMC 26381. PMID 8986788. Check date values in: |year= / |date= mismatch (help)
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W et al. (Apr 1997). "Large-scale concatenation cDNA sequencing". Genome Research 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174. CS1 maint: Date and year (link)
Popov S, Yu K, Kozasa T, Wilkie TM (Jul 1997). "The regulators of G protein signaling (RGS) domains of RGS4, RGS10, and GAIP retain GTPase activating protein activity in vitro". Proceedings of the National Academy of Sciences of the United States of America 94 (14): 7216–20. doi:10.1073/pnas.94.14.7216. PMC 23796. PMID 9207071. CS1 maint: Date and year (link)
Shuey DJ, Betty M, Jones PG, Khawaja XZ, Cockett MI (May 1998). "RGS7 attenuates signal transduction through the G(alpha q) family of heterotrimeric G proteins in mammalian cells". Journal of Neurochemistry 70 (5): 1964–72. doi:10.1046/j.1471-4159.1998.70051964.x. PMID 9572280. CS1 maint: Date and year (link)

PDB gallery

1agr: COMPLEX OF ALF4-ACTIVATED GI-ALPHA-1 WITH RGS4

1as0: GTP-GAMMA-S BOUND G42V GIA1

1as2: GDP+PI BOUND G42V GIA1

1as3: GDP BOUND G42V GIA1

1bh2: A326S MUTANT OF AN INHIBITORY ALPHA SUBUNIT

1bof: GI-ALPHA-1 BOUND TO GDP AND MAGNESIUM

1cip: GI-ALPHA-1 SUBUNIT OF GUANINE NUCLEOTIDE-BINDING PROTEIN COMPLEXED WITH A GTP ANALOGUE

1gdd: TERTIARY AND QUATERNARY STRUCTURAL CHANGES IN GIA1 INDUCED BY GTP HYDROLYSIS

1gfi: STRUCTURES OF ACTIVE CONFORMATIONS OF GI ALPHA 1 AND THE MECHANISM OF GTP HYDROLYSIS

1gg2: G PROTEIN HETEROTRIMER MUTANT GI_ALPHA_1(G203A) BETA_1 GAMMA_2 WITH GDP BOUND

1gia: STRUCTURE OF ACTIVE CONFORMATIONS OF GIA1 AND THE MECHANISM OF GTP HYDROLYSIS

1gil: STRUCTURE OF ACTIVE CONFORMATIONS OF GIA1 AND THE MECHANISM OF GTP HYDROLYSIS

1git: STRUCTURE OF GTP-BINDING PROTEIN

1gp2: G PROTEIN HETEROTRIMER GI_ALPHA_1 BETA_1 GAMMA_2 WITH GDP BOUND

1kjy: Crystal Structure of Human G[alpha]i1 Bound to the GoLoco Motif of RGS14

1svk: Structure of the K180P mutant of Gi alpha subunit bound to AlF4 and GDP

1svs: Structure of the K180P mutant of Gi alpha subunit bound to GppNHp.

1y3a: Structure of G-Alpha-I1 bound to a GDP-selective peptide provides insight into guanine nucleotide exchange

2g83: Structure of activated G-alpha-i1 bound to a nucleotide-state-selective peptide: Minimal determinants for recognizing the active form of a G protein alpha subunit

2gtp: Crystal structure of the heterodimeric complex of human RGS1 and activated Gi alpha 1

2hlb: A Structural Basis for Nucleotide Exchange on G-alpha-i Subunits and Receptor Coupling Specificity

2ihb: Crystal structure of the heterodimeric complex of human RGS10 and activated Gi alpha 3

2ik8: Crystal structure of the heterodimeric complex of human RGS16 and activated Gi alpha 1

2ode: Crystal structure of the heterodimeric complex of human RGS8 and activated Gi alpha 3

Hydrolases: acid anhydride hydrolases (EC 3.6)

3.6.1

3.6.2

3.6.3-4: ATPase

3.6.3

Cu++ (3.6.3.4)	Menkes/ATP7A Wilson/ATP7B

Ca+ (3.6.3.8)	SERCA ATP2A1 ATP2A2 ATP2A3 Plasma membrane ATP2B1 ATP2B2 ATP2B3 ATP2B4 SPCA ATP2C1 ATP2C2

Na+/K+ (3.6.3.9)	ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B1 ATP1B2 ATP1B3 ATP1B4

H+/K+ (3.6.3.10)	ATP4A

Other P-type ATPase	ATP8B1 ATP10A ATP11B ATP12A ATP13A2 ATP13A3

3.6.4

3.6.5: GTPase

3.6.5.1: Heterotrimeric G protein	G_αs G_αi GNAI1 GNAI2 GNAI3 G_αq/11 GNAQ GNA11 G_α12/13 GNA12 GNA13 Transducin GNAT1 GNAT2

3.6.5.2: Small GTPase > Ras superfamily	Rho family of GTPases: Cdc42 CDC42 TC10 TCL RhoUV RhoU RhoV Rac Rac1 2 3 RhoG RhoBTB 1 2 RhoH Rho A B C Rnd 1 2 3 RhoDF RhoF RhoD other: Ras HRAS KRAS NRAS Rab RAB23 RAB27 Arf ARF6 SAR1B ARL13B ARL6 Ran Rheb Rap RGK

3.6.5.3: Protein-synthesizing GTPase	Prokaryotic IF-2 EF-Tu EF-G Eukaryotic

3.6.5.5-6: Polymerization motors	Dynamin Tubulin

Biochemistry overview
Enzymes overview
By EC number: 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
2.1
- 2
- 3
- 4
- 5
- 6
- 7
  - 2.7.10
  - 11-12
- 8
3.1
- - 3.1.3.48
- 2
- 3
- 4
  - 3.4.21
  - 22
  - 23
  - 24
- 5
- 6
- 7
4.1
- 2
- 3
- 4
- 5
- 6
5.1
- 2
- 3
- 4
- 99
6.1-3
- 4
- 5-6

GNAI1

Interactive pathway map

Interactions

References

Further reading