GLUD2

Glutamate dehydrogenase 2

PDB rendering based on 1hwx.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1hwx, 1hwy, 1hwz, 1l1f, 1nqt, 1nr1, 1nr7

Identifiers

Symbols

GLUD2 ; GDH2; GLUDP1

External IDs

OMIM: 300144 HomoloGene: 115647 GeneCards: GLUD2 Gene

EC number

1.4.1.3

Gene ontology
Molecular function	• glutamate dehydrogenase (NAD+) activity • glutamate dehydrogenase [NAD(P)+ activity] • GTP binding • ADP binding • leucine binding
Cellular component	• cytoplasm • mitochondrion
Biological process	• glutamate metabolic process • glutamate biosynthetic process • glutamate catabolic process • oxidation-reduction process
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

n/a

n/a

n/a

RefSeq (mRNA)

NM_012084

n/a

RefSeq (protein)

NP_036216

n/a

Location (UCSC)

Chr X:
120.18 – 120.18 Mb

n/a

PubMed search

n/a

Glutamate dehydrogenase 2, mitochondrial, also known as GDH 2, is an enzyme that in humans is encoded by the GLUD2 gene.^[1]^[2]^[3]

Function

Glutamate dehydrogenase 2 is localized to the mitochondrion and acts as a homohexamer to recycle glutamate during neurotransmission. The encoded enzyme catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate.^[1]

References

↑ 1.0 1.1 "Entrez Gene: glutamate dehydrogenase 2".
↑ Shashidharan P, Michaelidis TM, Robakis NK, Kresovali A, Papamatheakis J, Plaitakis A (June 1994). "Novel human glutamate dehydrogenase expressed in neural and testicular tissues and encoded by an X-linked intronless gene". J. Biol. Chem. 269 (24): 16971–6. PMID 8207021.
↑ Shashidharan P, Clarke DD, Ahmed N, Moschonas N, Plaitakis A (May 1997). "Nerve tissue-specific human glutamate dehydrogenase that is thermolabile and highly regulated by ADP". J. Neurochem. 68 (5): 1804–11. doi:10.1046/j.1471-4159.1997.68051804.x. PMID 9109504.

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