GLRB

"GLRB" is also the ICAO code for Roberts International Airport near Monrovia, Liberia.
Glycine receptor, beta

PDB rendering based on 1t3e.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsGLRB ; HKPX2
External IDsOMIM: 138492 MGI: 95751 HomoloGene: 20224 IUPHAR: 427 GeneCards: GLRB Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez274314658
EnsemblENSG00000109738ENSMUSG00000028020
UniProtP48167P48168
RefSeq (mRNA)NM_000824NM_001281969
RefSeq (protein)NP_000815NP_001268898
Location (UCSC)Chr 4:
158 – 158.09 Mb		Chr 3:
80.84 – 80.91 Mb
PubMed search

Glycine receptor subunit beta is a protein that in humans is encoded by the GLRB gene.[1][2][3]

The inhibitory glycine receptor mediates postsynaptic inhibition in the spinal cord and other regions of the central nervous system. It is a pentameric receptor composed of alpha (GLRA1, MIM 138491; GLRA2, MIM 305990) and beta subunits.[supplied by OMIM][3]

See also

References

  1. ↑ Milani N, Mulhardt C, Weber RG, Lichter P, Kioschis P, Poustka A, Becker CM (Oct 1998). "The human glycine receptor beta subunit gene (GLRB): structure, refined chromosomal localization, and population polymorphism". Genomics 50 (3): 341–5. doi:10.1006/geno.1998.5324. PMID 9676428.
  2. ↑ Handford CA, Lynch JW, Baker E, Webb GC, Ford JH, Sutherland GR, Schofield PR (Oct 1996). "The human glycine receptor beta subunit: primary structure, functional characterisation and chromosomal localisation of the human and murine genes". Brain Res Mol Brain Res 35 (1–2): 211–9. doi:10.1016/0169-328x(95)00218-h. PMID 8717357.
  3. ↑ 3.0 3.1 "Entrez Gene: GLRB glycine receptor, beta".

Further reading

  • Meyer G, Kirsch J, Betz H, Langosch D (1995). "Identification of a gephyrin binding motif on the glycine receptor beta subunit". Neuron 15 (3): 563–72. doi:10.1016/0896-6273(95)90145-0. PMID 7546736.
  • Sarang SS, Miller GW, Grant DF, Schnellmann RG (1999). "Expression and localization of the neuronal glycine receptor beta-subunit in human, rabbit and rat kidneys". Nephron 82 (3): 254–60. doi:10.1159/000045410. PMID 10395998.
  • Rees MI, Lewis TM, Kwok JB et al. (2002). "Hyperekplexia associated with compound heterozygote mutations in the beta-subunit of the human inhibitory glycine receptor (GLRB)". Hum. Mol. Genet. 11 (7): 853–60. doi:10.1093/hmg/11.7.853. PMID 11929858.
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Chen Z, Dillon GH, Huang R (2004). "Molecular determinants of proton modulation of glycine receptors". J. Biol. Chem. 279 (2): 876–83. doi:10.1074/jbc.M307684200. PMID 14563849.
  • Burzomato V, Groot-Kormelink PJ, Sivilotti LG, Beato M (2004). "Stoichiometry of recombinant heteromeric glycine receptors revealed by a pore-lining region point mutation". Recept. Channels 9 (6): 353–61. PMID 14698963.
  • Harvey K, Duguid IC, Alldred MJ et al. (2004). "The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering". J. Neurosci. 24 (25): 5816–26. doi:10.1523/JNEUROSCI.1184-04.2004. PMID 15215304.
  • Grudzinska J, Schemm R, Haeger S et al. (2005). "The beta subunit determines the ligand binding properties of synaptic glycine receptors". Neuron 45 (5): 727–39. doi:10.1016/j.neuron.2005.01.028. PMID 15748848.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.