GLRA4

Glycine receptor, alpha 4

Identifiers

External IDs

MGI: 95750 HomoloGene: 69070 IUPHAR: 426 GeneCards: GLRA4 Gene

Gene ontology
Molecular function	• extracellular ligand-gated ion channel activity • chloride channel activity • glycine binding • transmitter-gated ion channel activity
Cellular component	• integral to plasma membrane • cell junction • chloride channel complex • postsynaptic membrane
Biological process	• ion transport
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr X:
102.96 – 102.98 Mb

Chr X:
136.76 – 136.78 Mb

PubMed search

The glycine receptor, alpha 4, also known as GLRA4, is a human pseudogene. The protein encoded by this gene is a subunit of the glycine receptor.^[1]

References

↑ Matzenbach B, Maulet Y, Sefton L, Courtier B, Avner P, Guénet JL, Betz H (28 January 1994). "Structural analysis of mouse glycine receptor alpha subunit genes. Identification and chromosomal localization of a novel variant". J. Biol. Chem. 269 (4): 2607–12. PMID 7507926.

External links

GLRA4 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

Ion channel, cell surface receptor: ligand-gated ion channels

Cys-loop receptors

5-HT/serotonin	5-HT₃ A B C D E

GABA	GABA_A α₁ α₂ α₃ α₄ α₅ α₆ β₁ β₂ β₃ γ₁ γ₂ γ₃ δ ε π θ GABA_A-ρ ρ₁ ρ₂ ρ₃

Glycine	α₁ α₂ α₃ α₄ β

Nicotinic acetylcholine	monomers: α1 α2 α3 α4 α5 α6 α7 α9 α10 β1 β2 β3 β4 δ ε pentamers: (α3)₂(β4)₃ (α4)₂(β2)₃ (α7)₅ (α1)₂(β4)₃ - Ganglion type (α1)₂β1δε - Muscle type

Zinc	Zinc-activated

Ionotropic glutamates

Ligand-gated only	AMPA (1 2 3 4) Kainate 1 2 3 4 5

Voltage- and ligand-gated	NMDA 1 2A 2B 2C 2D 3A 3B L1A L1B

‘Orphan’	GluD δ₁ δ₂

ATP-gated channels

Purinergic receptors	P2X 1 2 3 4 5 6 7

Index of signal transduction

Description	Intercellular neuropeptides growth factors cytokines hormones Cell surface receptors ligand-gated enzyme-linked G protein-coupled immunoglobulin superfamily integrins neuropeptide growth factor cytokine Intracellular adaptor proteins GTP-binding MAP kinase Calcium signaling Lipid signaling Pathways hedgehog Wnt TGF beta MAPK ERK notch JAK-STAT apoptosis hippo TLR