GGPS1
Geranylgeranyl pyrophosphate synthetase is an enzyme that in humans is encoded by the GGPS1 gene.[1][2][3]
This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[3]
Much like its homolog farnesyl diphosphate synthase, GGPS1 is inhibited by bisphosphonate compounds.[4]
References
- ↑ Ericsson J, Greene JM, Carter KC, Shell BK, Duan DR, Florence C, Edwards PA (Dec 1998). "Human geranylgeranyl diphosphate synthase: isolation of the cDNA, chromosomal mapping and tissue expression". J Lipid Res 39 (9): 1731–9. PMID 9741684.
- ↑ Kainou T, Kawamura K, Tanaka K, Matsuda H, Kawamukai M (May 1999). "Identification of the GGPS1 genes encoding geranylgeranyl diphosphate synthases from mouse and human". Biochim Biophys Acta 1437 (3): 333–40. doi:10.1016/S1388-1981(99)00028-1. PMID 10101267.
- ↑ 3.0 3.1 "Entrez Gene: GGPS1 geranylgeranyl diphosphate synthase 1".
- ↑ Wiemer, AJ; Wiemer, DF; Hohl, RJ (December 2011). "Geranylgeranyl diphosphate synthase: an emerging therapeutic target.". Clinical pharmacology and therapeutics 90 (6): 804–12. doi:10.1038/clpt.2011.215. PMID 22048229.
Further reading
- Ericsson J, Runquist M, Thelin A et al. (1993). "Distribution of prenyltransferases in rat tissues. Evidence for a cytosolic all-trans-geranylgeranyl diphosphate synthase.". J. Biol. Chem. 268 (2): 832–8. PMID 8419360.
- Kuzuguchi T, Morita Y, Sagami I et al. (1999). "Human geranylgeranyl diphosphate synthase. cDNA cloning and expression.". J. Biol. Chem. 274 (9): 5888–94. doi:10.1074/jbc.274.9.5888. PMID 10026212.
- Hu RM, Han ZG, Song HD et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
- Bommel H, Xie G, Rossoll W et al. (2003). "Missense mutation in the tubulin-specific chaperone E (Tbce) gene in the mouse mutant progressive motor neuronopathy, a model of human motoneuron disease.". J. Cell Biol. 159 (4): 563–9. doi:10.1083/jcb.200208001. PMC 2173089. PMID 12446740.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Kavanagh KL, Dunford JE, Bunkoczi G et al. (2006). "The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding.". J. Biol. Chem. 281 (31): 22004–12. doi:10.1074/jbc.M602603200. PMID 16698791.
- Gregory SG, Barlow KF, McLay KE et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
- Ma J, Dempsey AA, Stamatiou D et al. (2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects.". Atherosclerosis 191 (1): 63–72. doi:10.1016/j.atherosclerosis.2006.05.032. PMID 16806233.
- Raz T, Nardi V, Azam M et al. (2007). "Farnesyl transferase inhibitor resistance probed by target mutagenesis.". Blood 110 (6): 2102–9. doi:10.1182/blood-2006-12-064907. PMC 1976354. PMID 17536018.
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