GGA2
| Golgi-associated, gamma adaptin ear containing, ARF binding protein 2 | |||||||||||||
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 PDB rendering based on 1mhq. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | GGA2 ; VEAR | ||||||||||||
| External IDs | OMIM: 606005 MGI: 1921355 HomoloGene: 22860 GeneCards: GGA2 Gene | ||||||||||||
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| Species | Human | Mouse | |||||||||||
| Entrez | 23062 | 74105 | |||||||||||
| Ensembl | ENSG00000103365 | ENSMUSG00000030872 | |||||||||||
| UniProt | Q9UJY4 | Q6P5E6 | |||||||||||
| RefSeq (mRNA) | NM_015044 | NM_028758 | |||||||||||
| RefSeq (protein) | NP_055859 | NP_083034 | |||||||||||
| Location (UCSC) | Chr 16: 23.47 – 23.53 Mb | Chr 7: 121.99 – 122.02 Mb | |||||||||||
| PubMed search | |||||||||||||
ADP-ribosylation factor-binding protein GGA2 is a protein that in humans is encoded by the GGA2 gene.[1][2][3]
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly.[3]
Interactions
GGA2 has been shown to interact with RABEP1,[4] Sortilin 1,[5][6] BACE2[7] and CLINT1.[8][9]
References
- ↑ Hirst J, Lui WW, Bright NA, Totty N, Seaman MN, Robinson MS (May 2000). "A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome". J Cell Biol 149 (1): 67–80. doi:10.1083/jcb.149.1.67. PMC 2175106. PMID 10747088.
- ↑ Boman AL, Zhang C, Zhu X, Kahn RA (Jul 2000). "A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi". Mol Biol Cell 11 (4): 1241–55. doi:10.1091/mbc.11.4.1241. PMC 14844. PMID 10749927.
- ↑ 3.0 3.1 "Entrez Gene: GGA2 golgi associated, gamma adaptin ear containing, ARF binding protein 2".
- ↑ Mattera, Rafael; Arighi Cecilia N; Lodge Robert; Zerial Marino; Bonifacino Juan S (Jan 2003). "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex". EMBO J. (England) 22 (1): 78–88. doi:10.1093/emboj/cdg015. ISSN 0261-4189. PMC 140067. PMID 12505986.
- ↑ Nielsen, M S; Madsen P; Christensen E I; Nykjaer A; Gliemann J; Kasper D; Pohlmann R; Petersen C M (May 2001). "The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein". EMBO J. (England) 20 (9): 2180–90. doi:10.1093/emboj/20.9.2180. ISSN 0261-4189. PMC 125444. PMID 11331584.
- ↑ Jacobsen, Linda; Madsen Peder; Nielsen Morten S; Geraerts Wijnand P M; Gliemann Jørgen; Smit August B; Petersen Claus M (Jan 2002). "The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding". FEBS Lett. (Netherlands) 511 (1–3): 155–8. doi:10.1016/S0014-5793(01)03299-9. ISSN 0014-5793. PMID 11821067.
- ↑ He, Xiangyuan; Chang Wan-Pin; Koelsch Gerald; Tang Jordan (Jul 2002). "Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2". FEBS Lett. (Netherlands) 524 (1–3): 183–7. doi:10.1016/S0014-5793(02)03052-1. ISSN 0014-5793. PMID 12135764.
- ↑ Wasiak, Sylwia; Legendre-Guillemin Valerie, Puertollano Rosa, Blondeau Francois, Girard Martine, de Heuvel Elaine, Boismenu Daniel, Bell Alexander W, Bonifacino Juan S, McPherson Peter S (Sep 2002). "Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics". J. Cell Biol. (United States) 158 (5): 855–62. doi:10.1083/jcb.200205078. ISSN 0021-9525. PMC 2173151. PMID 12213833.
- ↑ Kalthoff, Christoph; Groos Stephanie; Kohl Rüdiger; Mahrhold Stefan; Ungewickell Ernst J (Nov 2002). "Clint: a novel clathrin-binding ENTH-domain protein at the Golgi". Mol. Biol. Cell (United States) 13 (11): 4060–73. doi:10.1091/mbc.E02-03-0171. ISSN 1059-1524. PMC 133614. PMID 12429846.
Further reading
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Kikuno R, Nagase T, Ishikawa K et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
- Loftus BJ, Kim UJ, Sneddon VP et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
- Poussu A, Lohi O, Lehto VP (2000). "Vear, a novel Golgi-associated protein with VHS and gamma-adaptin "ear" domains". J. Biol. Chem. 275 (10): 7176–83. doi:10.1074/jbc.275.10.7176. PMID 10702286.
- Dell'Angelica EC, Puertollano R, Mullins C et al. (2000). "GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex". J. Cell Biol. 149 (1): 81–94. doi:10.1083/jcb.149.1.81. PMC 2175099. PMID 10747089.
- Takatsu H, Yoshino K, Nakayama K (2000). "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochem. Biophys. Res. Commun. 271 (3): 719–25. doi:10.1006/bbrc.2000.2700. PMID 10814529.
- Puertollano R, Randazzo PA, Presley JF et al. (2001). "The GGAs promote ARF-dependent recruitment of clathrin to the TGN". Cell 105 (1): 93–102. doi:10.1016/S0092-8674(01)00299-9. PMID 11301005.
- Nielsen MS, Madsen P, Christensen EI et al. (2001). "The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein". EMBO J. 20 (9): 2180–90. doi:10.1093/emboj/20.9.2180. PMC 125444. PMID 11331584.
- Puertollano R, Aguilar RC, Gorshkova I et al. (2001). "Sorting of mannose 6-phosphate receptors mediated by the GGAs". Science 292 (5522): 1712–6. doi:10.1126/science.1060750. PMID 11387475.
- Zhu Y, Doray B, Poussu A et al. (2001). "Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor". Science 292 (5522): 1716–8. doi:10.1126/science.1060896. PMID 11387476.
- Takatsu H, Katoh Y, Shiba Y, Nakayama K (2001). "Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p/Hrs/STAM (VHS) domains". J. Biol. Chem. 276 (30): 28541–5. doi:10.1074/jbc.C100218200. PMID 11390366.
- Jacobsen L, Madsen P, Nielsen MS et al. (2002). "The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding". FEBS Lett. 511 (1–3): 155–8. doi:10.1016/S0014-5793(01)03299-9. PMID 11821067.
- Doray B, Bruns K, Ghosh P, Kornfeld S (2002). "Interaction of the cation-dependent mannose 6-phosphate receptor with GGA proteins". J. Biol. Chem. 277 (21): 18477–82. doi:10.1074/jbc.M201879200. PMID 11886874.
- Takatsu H, Yoshino K, Toda K, Nakayama K (2002). "GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors". Biochem. J. 365 (Pt 2): 369–78. doi:10.1042/BJ20020428. PMC 1222692. PMID 11950392.
- He X, Chang WP, Koelsch G, Tang J (2002). "Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2". FEBS Lett. 524 (1–3): 183–7. doi:10.1016/S0014-5793(02)03052-1. PMID 12135764.
- Wasiak S, Legendre-Guillemin V, Puertollano R et al. (2002). "Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics". J. Cell Biol. 158 (5): 855–62. doi:10.1083/jcb.200205078. PMC 2173151. PMID 12213833.
- Kalthoff C, Groos S, Kohl R et al. (2003). "Clint: a novel clathrin-binding ENTH-domain protein at the Golgi". Mol. Biol. Cell 13 (11): 4060–73. doi:10.1091/mbc.E02-03-0171. PMC 133614. PMID 12429846.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
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