GEMIN5
| Gem (nuclear organelle) associated protein 5 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | GEMIN5 ; GEMIN-5 | ||||||||||||
| External IDs | OMIM: 607005 MGI: 2449311 HomoloGene: 9155 GeneCards: GEMIN5 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 25929 | 216766 | |||||||||||
| Ensembl | ENSG00000082516 | ENSMUSG00000037275 | |||||||||||
| UniProt | Q8TEQ6 | Q8BX17 | |||||||||||
| RefSeq (mRNA) | NM_001252156 | NM_001166669 | |||||||||||
| RefSeq (protein) | NP_001239085 | NP_001160141 | |||||||||||
| Location (UCSC) | Chr 5: 154.27 – 154.32 Mb | Chr 11: 58.12 – 58.17 Mb | |||||||||||
| PubMed search | |||||||||||||
Gem-associated protein 5 is a protein that in humans is encoded by the GEMIN5 gene.[1][2]
Function
GEMIN5 is part of a large macromolecular complex localized to both the cytoplasm and the nucleus that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), GEMIN2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), and GEMIN4 (MIM 606969).[2]
Interactions
GEMIN5 has been shown to interact with DDX20[1][3] and SMN1.[1]
References
- ↑ 1.0 1.1 1.2 Gubitz AK, Mourelatos Z, Abel L, Rappsilber J, Mann M, Dreyfuss G (Feb 2002). "Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins". J Biol Chem 277 (7): 5631–6. doi:10.1074/jbc.M109448200. PMID 11714716.
- ↑ 2.0 2.1 "Entrez Gene: GEMIN5 gem (nuclear organelle) associated protein 5".
- ↑ Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L et al. (Mar 2002). "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs". Genes Dev. 16 (6): 720–8. doi:10.1101/gad.974702. PMC 155365. PMID 11914277.
Further reading
- Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". J. Biol. Chem. 277 (35): 31957–62. doi:10.1074/jbc.M203478200. PMID 12065586.
- Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. Vancouver style error (help)
- Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Battle DJ, Lau CK, Wan L, Deng H, Lotti F, Dreyfuss G (2006). "The Gemin5 protein of the SMN complex identifies snRNAs". Mol. Cell 23 (2): 273–9. doi:10.1016/j.molcel.2006.05.036. PMID 16857593.
- Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. Vancouver style error (help)
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Kim EK, Noh KT, Yoon JH, Cho JH, Yoon KW, Dreyfuss G et al. (2007). "Positive regulation of ASK1-mediated c-Jun NH(2)-terminal kinase signaling pathway by the WD-repeat protein Gemin5". Cell Death Differ. 14 (8): 1518–28. doi:10.1038/sj.cdd.4402157. PMID 17541429.
- Hao le T, Fuller HR, Lam le T, Le TT, Burghes AH, Morris GE (2007). "Absence of gemin5 from SMN complexes in nuclear Cajal bodies". BMC Cell Biol. 8: 28. doi:10.1186/1471-2121-8-28. PMC 1939999. PMID 17640370.
- Battle DJ, Kasim M, Wang J, Dreyfuss G (2007). "SMN-independent subunits of the SMN complex. Identification of a small nuclear ribonucleoprotein assembly intermediate". J. Biol. Chem. 282 (38): 27953–9. doi:10.1074/jbc.M702317200. PMID 17640873.
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