GCA (gene)
| Grancalcin, EF-hand calcium binding protein | |||||||||||||
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 PDB rendering based on 1f4o. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | GCA ; GCL | ||||||||||||
| External IDs | OMIM: 607030 MGI: 1918521 HomoloGene: 22702 GeneCards: GCA Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 25801 | 227960 | |||||||||||
| Ensembl | ENSG00000115271 | ENSMUSG00000026893 | |||||||||||
| UniProt | P28676 | Q8VC88 | |||||||||||
| RefSeq (mRNA) | NM_012198 | NM_145523 | |||||||||||
| RefSeq (protein) | NP_036330 | NP_663498 | |||||||||||
| Location (UCSC) | Chr 2: 163.18 – 163.23 Mb | Chr 2: 62.66 – 62.69 Mb | |||||||||||
| PubMed search | |||||||||||||
Grancalcin is a protein that in humans is encoded by the GCA gene.[1][2][3][4]
This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation.[4]
Interactions
GCA (gene) has been shown to interact with SRI.[3]
References
- ↑ Boyhan A, Casimir CM, French JK, Teahan CG, Segal AW (Mar 1992). "Molecular cloning and characterization of grancalcin, a novel EF-hand calcium-binding protein abundant in neutrophils and monocytes". J Biol Chem 267 (5): 2928–33. PMID 1737748.
- ↑ Teahan CG, Totty NF, Segal AW (Oct 1992). "Isolation and characterization of grancalcin, a novel 28 kDa EF-hand calcium-binding protein from human neutrophils". Biochem J. 286. ( Pt 2): 549–54. PMC 1132932. PMID 1530588.
- ↑ 3.0 3.1 Hansen C, Tarabykina S, la Cour JM, Lollike K, Berchtold MW (Jun 2003). "The PEF family proteins sorcin and grancalcin interact in vivo and in vitro". FEBS Lett 545 (2-3): 151–4. doi:10.1016/S0014-5793(03)00518-0. PMID 12804766.
- ↑ 4.0 4.1 "Entrez Gene: GCA grancalcin, EF-hand calcium binding protein".
Further reading
- Lim J, Hao T, Shaw C et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Hillier LW, Graves TA, Fulton RS et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Jia J, Borregaard N, Lollike K, Cygler M (2002). "Structure of Ca(2+)-loaded human grancalcin.". Acta Crystallogr. D Biol. Crystallogr. 57 (Pt 12): 1843–9. doi:10.1107/S0907444901016511. PMID 11717497.
- Lollike K, Johnsen AH, Durussel I et al. (2001). "Biochemical characterization of the penta-EF-hand protein grancalcin and identification of L-plastin as a binding partner.". J. Biol. Chem. 276 (21): 17762–9. doi:10.1074/jbc.M100965200. PMID 11279160.
- Jia J, Han Q, Borregaard N et al. (2000). "Crystal structure of human grancalcin, a member of the penta-EF-hand protein family.". J. Mol. Biol. 300 (5): 1271–81. doi:10.1006/jmbi.2000.3925. PMID 10903868.
- Maki M, Narayana SV, Hitomi K (1998). "A growing family of the Ca2+-binding proteins with five EF-hand motifs.". Biochem. J. 328. ( Pt 2): 718–20. PMC 1218977. PMID 9441591.
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