GABRP
| Gamma-aminobutyric acid (GABA) A receptor, pi | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | GABRP ; MGC126386; MGC126387 | ||||||||||||
| External IDs | OMIM: 602729 MGI: 2387597 HomoloGene: 22798 IUPHAR: 419 ChEMBL: 3506 GeneCards: GABRP Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 2568 | 216643 | |||||||||||
| Ensembl | ENSG00000094755 | ENSMUSG00000020159 | |||||||||||
| UniProt | O00591 | Q8QZW7 | |||||||||||
| RefSeq (mRNA) | NM_001291985 | NM_146017 | |||||||||||
| RefSeq (protein) | NP_001278914 | NP_666129 | |||||||||||
| Location (UCSC) | Chr 5: 170.19 – 170.24 Mb | Chr 11: 33.55 – 33.58 Mb | |||||||||||
| PubMed search | |||||||||||||
Gamma-aminobutyric acid receptor subunit pi is a protein that in humans is encoded by the GABRP gene.[1][2]
The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. The subunit encoded by this gene is expressed in several non-neuronal tissues including the uterus and ovaries. This subunit can assemble with known GABA A receptor subunits, and the presence of this subunit alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone.[2]
See also
References
- ↑ Hedblom E, Kirkness EF (Jul 1997). "A novel class of GABAA receptor subunit in tissues of the reproductive system". J Biol Chem 272 (24): 15346–50. doi:10.1074/jbc.272.24.15346. PMID 9182563.
- ↑ 2.0 2.1 "Entrez Gene: GABRP gamma-aminobutyric acid (GABA) A receptor, pi".
Further reading
- Mehta AK, Ticku MK (1999). "An update on GABAA receptors.". Brain Res. Brain Res. Rev. 29 (2–3): 196–217. doi:10.1016/S0165-0173(98)00052-6. PMID 10209232.
- Zafrakas M, Chorovicer M, Klaman I et al. (2007). "Systematic characterisation of GABRP expression in sporadic breast cancer and normal breast tissue". Int. J. Cancer 118 (6): 1453–9. doi:10.1002/ijc.21517. PMID 16187283.
- Petryshen TL, Middleton FA, Tahl AR et al. (2006). "Genetic investigation of chromosome 5q GABAA receptor subunit genes in schizophrenia". Mol. Psychiatry 10 (12): 1074–88, 1057. doi:10.1038/sj.mp.4001739. PMID 16172613.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Galey D, Becker K, Haughey N et al. (2003). "Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes". J. Neurovirol. 9 (3): 358–71. doi:10.1080/13550280390201119. PMID 12775419.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Neelands TR, Macdonald RL (1999). "Incorporation of the pi subunit into functional gamma-aminobutyric Acid(A) receptors". Mol. Pharmacol. 56 (3): 598–610. PMID 10462548.
- Taylor PM, Thomas P, Gorrie GH et al. (1999). "Identification of amino acid residues within GABA(A) receptor beta subunits that mediate both homomeric and heteromeric receptor expression". J. Neurosci. 19 (15): 6360–71. PMID 10414965.
External links
- GABRP protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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