GABRG1
| Gamma-aminobutyric acid (GABA) A receptor, gamma 1 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | GABRG1 ; DKFZp686H2042; MGC33838 | ||||||||||||
| External IDs | OMIM: 137166 MGI: 103156 HomoloGene: 22570 IUPHAR: 413 ChEMBL: 4044 GeneCards: GABRG1 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 2565 | 14405 | |||||||||||
| Ensembl | ENSG00000163285 | ENSMUSG00000001260 | |||||||||||
| UniProt | Q8N1C3 | Q9R0Y8 | |||||||||||
| RefSeq (mRNA) | NM_173536 | NM_010252 | |||||||||||
| RefSeq (protein) | NP_775807 | NP_034382 | |||||||||||
| Location (UCSC) | Chr 4: 46.04 – 46.13 Mb | Chr 5: 70.75 – 70.84 Mb | |||||||||||
| PubMed search | |||||||||||||
Gamma-aminobutyric acid receptor subunit gamma-1 is a protein that in humans is encoded by the GABRG1 gene.[1] The protein encoded by this gene is a subunit of the GABAA receptor.[2]
Variants of this gene may be associated with alcohol dependence.[3]
References
- ↑ Wilcox AS, Warrington JA, Gardiner K, Berger R, Whiting P, Altherr MR, Wasmuth JJ, Patterson D, Sikela JM (July 1992). "Human chromosomal localization of genes encoding the gamma 1 and gamma 2 subunits of the gamma-aminobutyric acid receptor indicates that members of this gene family are often clustered in the genome". Proc. Natl. Acad. Sci. U.S.A. 89 (13): 5857–61. doi:10.1073/pnas.89.13.5857. PMC 49396. PMID 1321425.
- ↑ Hevers W, Lüddens H (August 1998). "The diversity of GABAA receptors. Pharmacological and electrophysiological properties of GABAA channel subtypes". Mol. Neurobiol. 18 (1): 35–86. doi:10.1007/BF02741459. PMID 9824848.
- ↑ Ittiwut C, Listman J, Mutirangura A, Malison R, Covault J, Kranzler HR, Sughondhabirom A, Thavichachart N, Gelernter J (January 2008). "Interpopulation linkage disequilibrium patterns of GABRA2 and GABRG1 genes at the GABA cluster locus on human chromosome 4". Genomics 91 (1): 61–9. doi:10.1016/j.ygeno.2007.08.007. PMC 2709929. PMID 17976953.
Further reading
- Nymann-Andersen J, Wang H, Chen L et al. (2002). "Subunit specificity and interaction domain between GABA(A) receptor-associated protein (GABARAP) and GABA(A) receptors.". J. Neurochem. 80 (5): 815–23. doi:10.1046/j.0022-3042.2002.00762.x. PMID 11948245.
- Iwakiri M, Mizukami K, Ikonomovic MD et al. (2009). "An immunohistochemical study of GABA A receptor gamma subunits in Alzheimer's disease hippocampus: relationship to neurofibrillary tangle progression.". Neuropathology 29 (3): 263–9. doi:10.1111/j.1440-1789.2008.00978.x. PMC 3078755. PMID 19019179.
- Craddock N, Jones L, Jones IR et al. (2010). "Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype.". Mol. Psychiatry 15 (2): 146–53. doi:10.1038/mp.2008.66. PMID 19078961.
- Ray LA, Hutchison KE (2009). "Associations among GABRG1, level of response to alcohol, and drinking behaviors.". Alcohol. Clin. Exp. Res. 33 (8): 1382–90. doi:10.1111/j.1530-0277.2009.00968.x. PMC 2965732. PMID 19426171.
- Ittiwut C, Listman J, Mutirangura A et al. (2008). "Interpopulation linkage disequilibrium patterns of GABRA2 and GABRG1 genes at the GABA cluster locus on human chromosome 4". Genomics 91 (1): 61–9. doi:10.1016/j.ygeno.2007.08.007. PMC 2709929. PMID 17976953.
- Gratacòs M, Costas J, de Cid R et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–16. doi:10.1002/ajmg.b.30902. PMID 19086053.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Bonnert TP, McKernan RM, Farrar S et al. (1999). "theta, a novel gamma-aminobutyric acid type A receptor subunit". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9891–6. doi:10.1073/pnas.96.17.9891. PMC 22306. PMID 10449790.
- Guilmatre A, Dubourg C, Mosca AL et al. (2009). "Recurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardation". Arch. Gen. Psychiatry 66 (9): 947–56. doi:10.1001/archgenpsychiatry.2009.80. PMC 2958844. PMID 19736351.
- Strausberg RL, Feingold EA, Grouse LH et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ma DQ, Whitehead PL, Menold MM et al. (2005). "Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism". Am. J. Hum. Genet. 77 (3): 377–88. doi:10.1086/433195. PMC 1226204. PMID 16080114.
- Covault J, Gelernter J, Jensen K et al. (2008). "Markers in the 5'-region of GABRG1 associate to alcohol dependence and are in linkage disequilibrium with markers in the adjacent GABRA2 gene". Neuropsychopharmacology 33 (4): 837–48. doi:10.1038/sj.npp.1301456. PMC 2743531. PMID 17507911.
- Enoch MA, Hodgkinson CA, Yuan Q et al. (2009). "GABRG1 and GABRA2 as independent predictors for alcoholism in two populations". Neuropsychopharmacology 34 (5): 1245–54. doi:10.1038/npp.2008.171. PMC 2656604. PMID 18818659.
- Wilcox AS, Warrington JA, Gardiner K et al. (1992). "Human chromosomal localization of genes encoding the gamma 1 and gamma 2 subunits of the gamma-aminobutyric acid receptor indicates that members of this gene family are often clustered in the genome". Proc. Natl. Acad. Sci. U.S.A. 89 (13): 5857–61. doi:10.1073/pnas.89.13.5857. PMC 49396. PMID 1321425.
External links
- GABRG1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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