GABRD
| Gamma-aminobutyric acid (GABA) A receptor, delta | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | GABRD ; EIG10; EJM7; GEFSP5 | ||||||||||||
| External IDs | OMIM: 137163 MGI: 95622 HomoloGene: 55489 IUPHAR: 416 ChEMBL: 3591 GeneCards: GABRD Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 2563 | 14403 | |||||||||||
| Ensembl | ENSG00000187730 | ENSMUSG00000029054 | |||||||||||
| UniProt | O14764 | P22933 | |||||||||||
| RefSeq (mRNA) | NM_000815 | NM_008072 | |||||||||||
| RefSeq (protein) | NP_000806 | NP_032098 | |||||||||||
| Location (UCSC) | Chr 1: 1.95 – 1.96 Mb | Chr 4: 155.38 – 155.4 Mb | |||||||||||
| PubMed search | |||||||||||||
Gamma-aminobutyric acid receptor subunit delta is a protein that in humans is encoded by the GABRD gene.[1][2][3]
Function
γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABAA receptors, which are ligand-gated chloride channels. The GABAA receptor is generally pentameric. Its five subunits are alpha, beta, gamma, delta, and rho. The GABRD gene encodes the delta subunit.[3]
Cell type-specific expression
In a technical comparison between quantitative reverse transcriptase PCR and digital PCR, the expression of the rat gabrd gene was examined across three cell types in the somatosensory cortex: neurogliaform cells, fast spiking basket cells and pyramidal cells.[4] Gene expression was detected in all three cell types, but showed marked enrichment in neurogliaform cells versus the other cell types examined.[4]
See also
References
- ↑ Sommer B, Poustka A, Spurr NK, Seeburg PH (Feb 1991). "The murine GABAA receptor delta-subunit gene: structure and assignment to human chromosome 1". DNA Cell Biol 9 (8): 561–8. doi:10.1089/dna.1990.9.561. PMID 2176788.
- ↑ Emberger W, Windpassinger C, Petek E, Kroisel PM, Wagner K (Sep 2000). "Assignment of the human GABAA receptor delta-subunit gene (GABRD) to chromosome band 1p36.3 distal to marker NIB1364 by radiation hybrid mapping". Cytogenet Cell Genet 89 (3-4): 281–2. doi:10.1159/000015636. PMID 10965146.
- ↑ 3.0 3.1 "Entrez Gene: GABRD gamma-aminobutyric acid (GABA) A receptor, delta".
- ↑ 4.0 4.1 Faragó Nóra, Kocsis AK, Lovas Sándor, Molnár Gábor, Boldog E, Rózsa Márton, Szemenyei V, Vámos Enikö, Nagy LI, Tamás Gábor, Puskás László G. (2013). "Digital PCR to determine the number of transcripts from single neurons after patch-clamp recording". BioTechniques 54 (6): 327–36. doi:10.2144/000114029. PMID 23750542. Vancouver style error (help)
Further reading
- Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
- Lenzen KP, Heils A, Lorenz S, Hempelmann A, Sander T (June 2005). "Association analysis of the Arg220His variation of the human gene encoding the GABA delta subunit with idiopathic generalized epilepsy". Epilepsy Res. 65 (1-2): 53–7. doi:10.1016/j.eplepsyres.2005.04.005. PMID 16023832.
- Windpassinger C, Kroisel PM, Wagner K, Petek E (June 2002). "The human gamma-aminobutyric acid A receptor delta (GABRD) gene: molecular characterisation and tissue-specific expression". Gene 292 (1-2): 25–31. doi:10.1016/S0378-1119(02)00649-2. PMID 12119096.
External links
- GABRD protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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