GABRA6
Gamma-aminobutyric acid receptor subunit alpha-6 is a protein that in humans is encoded by the GABRA6 gene.[1][2]
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.[2]
One study has found a genetic variant in the gene to be associated with the personality trait neuroticism.[3]
See also
References
- ↑ Hicks AA, Bailey ME, Riley BP, Kamphuis W, Siciliano MJ, Johnson KJ, Darlison MG (Aug 1994). "Further evidence for clustering of human GABAA receptor subunit genes: localization of the alpha 6-subunit gene (GABRA6) to distal chromosome 5q by linkage analysis". Genomics 20 (2): 285–8. doi:10.1006/geno.1994.1167. PMID 8020978.
- ↑ 2.0 2.1 "Entrez Gene: GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6".
- ↑ Srijan Sen, Sandra Villafuerte, Randolph Nesse, Scott F. Stoltenberg, Jeffrey Hopcian, Lillian Gleiberman, Alan Weder & Margit Burmeister (February 2004). "Serotonin transporter and GABAA alpha 6 receptor variants are associated with neuroticism". Biological Psychiatry 55 (3): 244–249. doi:10.1016/j.biopsych.2003.08.006. PMID 14744464.
Further reading
- Tögel M, Mossier B, Fuchs K, Sieghart W (1994). "gamma-Aminobutyric acidA receptors displaying association of gamma 3-subunits with beta 2/3 and different alpha-subunits exhibit unique pharmacological properties.". J. Biol. Chem. 269 (17): 12993–8. PMID 8175718.
- Hadingham KL, Garrett EM, Wafford KA et al. (1996). "Cloning of cDNAs encoding the human gamma-aminobutyric acid type A receptor alpha 6 subunit and characterization of the pharmacology of alpha 6-containing receptors.". Mol. Pharmacol. 49 (2): 253–9. PMID 8632757.
- Russek SJ (1999). "Evolution of GABA(A) receptor diversity in the human genome.". Gene 227 (2): 213–22. doi:10.1016/S0378-1119(98)00594-0. PMID 10023064.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Sen S, Villafuerte S, Nesse R et al. (2004). "Serotonin transporter and GABAA alpha 6 receptor variants are associated with neuroticism.". Biol. Psychiatry 55 (3): 244–9. doi:10.1016/j.biopsych.2003.08.006. PMID 14744464.
- Peran M, Hooper H, Rayner SL et al. (2004). "GABAA receptor alpha1 and alpha6 subunits mediate cell surface anchoring in cultured cells.". Neurosci. Lett. 364 (2): 67–70. doi:10.1016/j.neulet.2004.03.081. PMID 15196679.
- Uhart M, McCaul ME, Oswald LM et al. (2005). "GABRA6 gene polymorphism and an attenuated stress response.". Mol. Psychiatry 9 (11): 998–1006. doi:10.1038/sj.mp.4001535. PMID 15197399.
- Wang W, Stock RE, Gronostajski RM et al. (2005). "A role for nuclear factor I in the intrinsic control of cerebellar granule neuron gene expression.". J. Biol. Chem. 279 (51): 53491–7. doi:10.1074/jbc.M410370200. PMID 15466411.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Kimura K, Wakamatsu A, Suzuki Y et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Lucht M, Barnow S, Schroeder W et al. (2006). "Negative perceived paternal parenting is associated with dopamine D2 receptor exon 8 and GABA(A) alpha 6 receptor variants: an explorative study.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 141 (2): 167–72. doi:10.1002/ajmg.b.30255. PMID 16402352.
- Park CS, Park SY, Lee CS et al. (2007). "Association between alcoholism and the genetic polymorphisms of the GABAA receptor genes on chromosome 5q33-34 in Korean population.". J. Korean Med. Sci. 21 (3): 533–8. doi:10.3346/jkms.2006.21.3.533. PMC 2729963. PMID 16778401.
- Kobayashi Y, Akiyoshi J, Kanehisa M et al. (2007). "Lack of polymorphism in genes encoding mGluR 7, mGluR 8, GABA(A) receptor alfa-6 subunit and nociceptin/orphanin FQ receptor and panic disorder.". Psychiatr. Genet. 17 (1): 9. doi:10.1097/YPG.0b013e32801118bc. PMID 17167337.
- Lee YC, Wang HP, Chiu HM et al. (2007). "GABRA6 genetic polymorphism is associated with the risk of functional heartburn in Chinese.". J. Gastroenterol. Hepatol. 22 (2): 227–33. doi:10.1111/j.1440-1746.2006.04441.x. PMID 17295876.
External links
- GABRA6 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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