G-CSF factor stem-loop destabilising element
| G-CSF factor stem-loop destabilising element (SLDE) | |
|---|---|
 | |
| Predicted secondary structure and sequence conservation of G-CSF_SLDE | |
| Identifiers | |
| Symbol | G-CSF_SLDE |
| Rfam | RF00183 |
| Other data | |
| RNA type | Cis-reg |
| Domain(s) | Eukaryota |
| SO | 0000233 |
The G-CSF factor stem-loop destabilising element (SLDE) is an RNA element secreted by fibroblasts and endothelial cells in response to the inflammatory mediators interleukin-1 (IL-1) and tumour necrosis factor-alpha and by activated macrophages. The synthesis of G-CSF is regulated both transcriptionally and through control of mRNA stability. In unstimulated cells G-CSF mRNA is unstable but becomes stabilised in response to IL-1 or tumour necrosis factor alpha, and also in the case of monocytes and macrophages, in response to lipopolysaccharide. It is likely that the presence of the SLDE in the G-CSF mRNA contributes to the specificity of regulation of G-CSF mRNA and enhances the rate of shortening of the poly(A) tail.[1]
References
- ↑ Putland, RA; Sassinis TA; Harvey JS; Diamond P; Coles LS; Brown CY; Goodall GJ (2002). "RNA destabilization by the granulocyte colony-stimulating factor stem-loop destabilizing element involves a single stem-loop that promotes deadenylation". Mol Cell Biol 22 (6): 1664–1673. doi:10.1128/MCB.22.6.1664-1673.2002. PMC 135610. PMID 11865046.