Fusafungine

Fusafungine
Clinical data
AHFS/Drugs.com International Drug Names
Identifiers
1393-87-9 Yes
R02AB03
DrugBank DB08965 
UNII 65DD690W0C Yes
KEGG D08002 
Synonyms Fusafungin
Chemical data
Formula C29H51N2O8
555.72 g/mol[1]
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Fusafungine (INN), also known as fusafungin, is an active agent used in antibiotics for treatment of nasal and throat infection. It also possesses anti-inflammatory properties. Fusafungine is a mixture of enniatin cyclohexadepsipeptides made up of alternating D-α-hydroxyvaleric acid and L-N-methylamino acid residues,[2] produced by the ascomycete Fusarium lateritium, and marketed by Servier under the trade names Locabiotal, Bioparox, and Locabiosol.

According to a pooled analysis study done in the UK for the efficacy of fusafungine in rhinopharingitis, it was found that the proportion of patients who showed an improvement in symptoms from Day 0 to Day 4 of infection was 61.5% with fusafungine vs. 46.8% when compared to a placebo.[3]

References

  1. ↑ Fusafungine at MeSH
  2. ↑ Daniel Levy, Aline Bluzat, Michel Seigneuret and Jean-Louis Rigaud (1995). "Alkali cation transport through liposomes by the antimicrobial fusafungine and its constitutive enniatins". Biochemical Pharmacology 50 (12 22): 2105–2107. doi:10.1016/0006-2952(95)02045-4. PMID 8849339.
  3. ↑ Lund, V. J.; Grouin, J. M.; Eccles, R; Bouter, C; Chabolle, F (2004). "Efficacy of fusafungine in acute rhinopharyngitis: A pooled analysis". Rhinology 42 (4): 207–12. PMID 15626253.