Fosfluconazole

Fosfluconazole

Systematic (IUPAC) name
{[2-(2,4-Difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-yl]oxy}phosphonic acid
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	℞ (Prescription only)
Routes of administration	IV
Identifiers
CAS Registry Number	Y
ATC code	None
PubChem	CID 214356
ChemSpider	185843 Y
UNII	3JIJ299EWH Y
ChEMBL	CHEMBL1908301 Y
Chemical data
Formula	C13H13F2N6O4P
Molecular mass	386.25 g/mol
SMILES Fc1ccc(c(F)c1)C(OP(=O)(O)O)(Cn2ncnc2)Cn3ncnc3
InChI InChI=1S/C13H13F2N6O4P/c14-10-1-2-11(12(15)3-10)13(25-26(22,23)24,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9H,4-5H2,(H2,22,23,24)  Y Key:GHJWNRRCRIGGIO-UHFFFAOYSA-N  Y
N (what is this?)  (verify)

Fosfluconazole (INN) is a water-soluble phosphate prodrug of fluconazole - a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections. The phosphate ester bond is hydrolysed by the action of a phosphatase - an enzyme that removes a phosphate group from its substrate by hydrolysing phosphoric acid monoesters into a phosphate ion and a molecule with a free hydroxyl group (see dephosphorylation).