Formyl peptide receptor 1

Identifiers

FPR1 ; FMLP; FPR

External IDs

OMIM: 136537 MGI: 107443 HomoloGene: 20466 IUPHAR: 222 ChEMBL: 3359 GeneCards: FPR1 Gene

Gene ontology
Molecular function	• receptor activity • N-formyl peptide receptor activity • protein binding • RAGE receptor binding
Cellular component	• endosome • plasma membrane • integral component of membrane
Biological process	• activation of MAPK activity • cellular component movement • chemotaxis • signal transduction • G-protein coupled receptor signaling pathway • adenylate cyclase-modulating G-protein coupled receptor signaling pathway • phospholipase C-activating G-protein coupled receptor signaling pathway • nitric oxide mediated signal transduction
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 19:
52.25 – 52.31 Mb

Chr 17:
17.88 – 17.88 Mb

PubMed search

fMet-Leu-Phe receptor also known as the N-formyl peptide receptor is a protein that in humans is encoded by the FPR1 gene.^[1]^[2]^[3]

References

↑ Boulay F, Tardif M, Brouchon L, Vignais P (Jul 1990). "Synthesis and use of a novel N-formyl peptide derivative to isolate a human N-formyl peptide receptor cDNA". Biochem Biophys Res Commun 168 (3): 1103–9. doi:10.1016/0006-291X(90)91143-G. PMID 2161213.
↑ Zhang Y, Syed R, Uygar C, Pallos D, Gorry MC, Firatli E, Cortelli JR, VanDyke TE, Hart PS, Feingold E, Hart TC (Feb 2003). "Evaluation of human leukocyte N-formylpeptide receptor (FPR1) SNPs in aggressive periodontitis patients". Genes Immun 4 (1): 22–9. doi:10.1038/sj.gene.6363900. PMID 12595898.
↑ "Entrez Gene: FPR1 formyl peptide receptor 1".

Graves V, Gabig T, McCarthy L et al. (1992). "Simultaneous mobilization of Mac-1 (CD11b/CD18) and formyl peptide chemoattractant receptors in human neutrophils.". Blood 80 (3): 776–87. PMID 1322204.
Murphy PM, Ozçelik T, Kenney RT et al. (1992). "A structural homologue of the N-formyl peptide receptor. Characterization and chromosome mapping of a peptide chemoattractant receptor family.". J. Biol. Chem. 267 (11): 7637–43. PMID 1373134.
Perez HD, Holmes R, Kelly E et al. (1992). "Cloning of the gene coding for a human receptor for formyl peptides. Characterization of a promoter region and evidence for polymorphic expression.". Biochemistry 31 (46): 11595–9. doi:10.1021/bi00161a044. PMID 1445895.
Bao L, Gerard NP, Eddy RL et al. (1992). "Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19.". Genomics 13 (2): 437–40. doi:10.1016/0888-7543(92)90265-T. PMID 1612600.
Murphy PM, McDermott D (1991). "Functional expression of the human formyl peptide receptor in Xenopus oocytes requires a complementary human factor.". J. Biol. Chem. 266 (19): 12560–7. PMID 1712023.
Boulay F, Tardif M, Brouchon L, Vignais P (1991). "The human N-formylpeptide receptor. Characterization of two cDNA isolates and evidence for a new subfamily of G-protein-coupled receptors.". Biochemistry 29 (50): 11123–33. doi:10.1021/bi00502a016. PMID 2176894.
Wahl SM, Allen JB, Gartner S et al. (1989). "HIV-1 and its envelope glycoprotein down-regulate chemotactic ligand receptors and chemotactic function of peripheral blood monocytes.". J. Immunol. 142 (10): 3553–9. PMID 2541200.
Jesaitis AJ, Naemura JR, Painter RG et al. (1983). "Intracellular localization of N-formyl chemotactic receptor and Mg2+ dependent ATPase in human granulocytes.". Biochim. Biophys. Acta 719 (3): 556–68. doi:10.1016/0304-4165(82)90246-x. PMID 6129903.
Prossnitz ER, Kim CM, Benovic JL, Ye RD (1995). "Phosphorylation of the N-formyl peptide receptor carboxyl terminus by the G protein-coupled receptor kinase, GRK2.". J. Biol. Chem. 270 (3): 1130–7. doi:10.1074/jbc.270.3.1130. PMID 7836371.
Klotz KN, Jesaitis AJ (1994). "Physical coupling of N-formyl peptide chemoattractant receptors to G protein is unaffected by desensitization.". Biochem. Pharmacol. 48 (6): 1297–300. doi:10.1016/0006-2952(94)90168-6. PMID 7945424.
Bommakanti RK, Dratz EA, Siemsen DW, Jesaitis AJ (1994). "Characterization of complex formation between Gi2 and octyl glucoside solubilized neutrophil N-formyl peptide chemoattractant receptor by sedimentation velocity.". Biochim. Biophys. Acta 1209 (1): 69–76. doi:10.1016/0167-4838(94)90138-4. PMID 7947984.
Murphy PM, Tiffany HL, McDermott D, Ahuja SK (1993). "Sequence and organization of the human N-formyl peptide receptor-encoding gene.". Gene 133 (2): 285–90. doi:10.1016/0378-1119(93)90653-K. PMID 8224916.
Jesaitis AJ, Erickson RW, Klotz KN et al. (1993). "Functional molecular complexes of human N-formyl chemoattractant receptors and actin.". J. Immunol. 151 (10): 5653–65. PMID 8228254.
Särndahl E, Bokoch GM, Boulay F et al. (1996). "Direct or C5a-induced activation of heterotrimeric Gi2 proteins in human neutrophils is associated with interaction between formyl peptide receptors and the cytoskeleton.". J. Biol. Chem. 271 (25): 15267–71. doi:10.1074/jbc.271.25.15267. PMID 8663057.
Maestes DC, Potter RM, Prossnitz ER (1999). "Differential phosphorylation paradigms dictate desensitization and internalization of the N-formyl peptide receptor.". J. Biol. Chem. 274 (42): 29791–5. doi:10.1074/jbc.274.42.29791. PMID 10514456.
Liang TS, Wang JM, Murphy PM, Gao JL (2000). "Serum amyloid A is a chemotactic agonist at FPR2, a low-affinity N-formylpeptide receptor on mouse neutrophils.". Biochem. Biophys. Res. Commun. 270 (2): 331–5. doi:10.1006/bbrc.2000.2416. PMID 10753626.
Luu NT, Rainger GE, Nash GB (2000). "Differential ability of exogenous chemotactic agents to disrupt transendothelial migration of flowing neutrophils.". J. Immunol. 164 (11): 5961–9. doi:10.4049/jimmunol.164.11.5961. PMID 10820279.
Bennett TA, Maestas DC, Prossnitz ER (2000). "Arrestin binding to the G protein-coupled N-formyl peptide receptor is regulated by the conserved "DRY" sequence.". J. Biol. Chem. 275 (32): 24590–4. doi:10.1074/jbc.C000314200. PMID 10823817.
Ayala JM, Goyal S, Liverton NJ et al. (2000). "Serum-induced monocyte differentiation and monocyte chemotaxis are regulated by the p38 MAP kinase signal transduction pathway.". J. Leukoc. Biol. 67 (6): 869–75. PMID 10857861.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Cell surface receptor: G protein-coupled receptors

Class A: Rhodopsin like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3

Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)

Serotonin	(all but 5-HT3) 5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)

Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine (D1 D2 D3 D4 D5) Histamine (H1 H2 H3 H4) Melatonin (1A 1B 1C) TAAR (1 2 3 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 (1 2) FPRL1 OXE Prostaglandin (DP (1 2), EP (1 2 3 4), FP) Prostacyclin Thromboxane

Other	Bile acid Cannabinoid (CB1 CB2, GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Lactate Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Niacin (1 2) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide	B/W (1 2) FF (1 2) S Y (1 2 4 5) Neuromedin (B U (1 2)) Neurotensin (1 2)

Other	Anaphylatoxin (C3a C5a) Angiotensin (1 2) Apelin Bombesin (BRS3 GRPR NMBR) Bradykinin (B1 B2) Chemokine Cholecystokinin (A B) Endothelin (A B) Formyl peptide (1 2 3) FSH Galanin (1 2 3) GHB receptor Gonadotropin-releasing hormone (1 2) Ghrelin Kisspeptin Luteinizing hormone/choriogonadotropin MAS (1 1L D E F G X1 X2 X3 X4) Melanocortin (1 2 3 4 5) MCHR (1 2) Motilin Opioid (Delta Kappa Mu Nociceptin & Zeta, but not Sigma) Orexin (1 2) Oxytocin Prokineticin (1 2) Prolactin-releasing peptide Relaxin (1 2 3 4) Somatostatin (1 2 3 4 5) Tachykinin (1 2 3) Thyrotropin Thyrotropin-releasing hormone Urotensin-II Vasopressin (1A 1B 2)

Miscellaneous

Orphan	GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42 44 45 50 52 55 61 62 63 65 68 75 77 78 81 82 83 84 85 87 88 92 101 103 109A 109B 119 120 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)

Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B: Secretin like

Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)

Adhesion	ADGRG (1 2 3 4 5 6 7)

Other	Brain-specific angiogenesis inhibitor (1 2 3) Cadherin (1 2 3) Calcitonin CALCRL CD97 Corticotropin-releasing hormone (1 2) EMR (1 2 3) Glucagon (GR GIPR GLP1R GLP2R) Growth hormone releasing hormone PACAPR1 GPR Latrophilin (1 2 3 ELTD1) Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C: Metabotropic glutamate / pheromone

Taste	TAS1R (1 2 3) TAS2R (1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60)

Other	Calcium-sensing receptor GABA B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)

Class F: Frizzled / Smoothened

Frizzled	Frizzled (1 2 3 4 5 6 7 8 9 10)

Smoothened	Smoothened

Index of signal transduction

Description	Intercellular neuropeptides growth factors cytokines hormones Cell surface receptors ligand-gated enzyme-linked G protein-coupled immunoglobulin superfamily integrins neuropeptide growth factor cytokine Intracellular adaptor proteins GTP-binding MAP kinase Calcium signaling Lipid signaling Pathways hedgehog Wnt TGF beta MAPK ERK notch JAK-STAT apoptosis hippo TLR

Formyl peptide receptor 1

See also

References

Further reading