Foreign-body giant cell
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Histopathologic image of aspiration pneumonia in an elderly patient with debilitating neurologic illness. Note foreign-body giant cell reaction. Autopsy case. H & E stain.
A foreign-body giant cell is a collection of fused macrophages (giant cell) which are generated in response to the presence of a large foreign body. This is particularly evident with implants that cause the body chronic inflammation and foreign body response.[1] This reaction to the implant causes damages to the infected area, leaving the exterior surface with scars. [2]
The nuclei are arranged in a disorganized manner.[3] The nuclei in this cell are centrally placed and overlap each other. [4] This is in contrast to a Langhans giant cell, where the nuclei are arranged on the border.
Additional images
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Foreign-body giant cell reaction to a suture. H&E stain.
Small image of an infected area of the body due to a reaction with an implant
References
- ↑ Foreign Body Giant Cell at the US National Library of Medicine Medical Subject Headings (MeSH)
- ↑ Mcnally, Amy. "Giant Cell Formation". Retrieved May 21, 2013.
- ↑ "Inflammation".
- ↑ "Giant cells in chronic inflammation". Retrieved May 21, 2013.
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