Fluvastatin


Fluvastatin
Systematic (IUPAC) name
(3R,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid
Clinical data
Trade names Lescol
AHFS/Drugs.com monograph
MedlinePlus a694010
  • AU: D
  • US: X (Contraindicated)
Oral
Pharmacokinetic data
Bioavailability 30%[1]
Protein binding >98%[1]
Metabolism Hepatic (CYP2C9 (75%), CYP2C8 (5%), CYP3A4 (20%))[1][2]
Half-life 1-3 hours (capsule), 9 hours (XR)[1][2]
Excretion Faeces (95%), urine (5%)[1]
Identifiers
93957-54-1 Yes
C10AA04
PubChem CID 446155
DrugBank DB01095 Yes
ChemSpider 393587 Yes
UNII 4L066368AS Yes
KEGG D07983 Yes
ChEBI CHEBI:38565 Yes
ChEMBL CHEMBL1078 Yes
Chemical data
Formula C24H26FNO4
411.466 g/mol
 Yes (what is this?)  (verify)

Fluvastatin (trade names Lescol, Canef, Vastin) is a member of the drug class of statins, used to treat hypercholesterolemia and to prevent cardiovascular disease.

It has also been shown to exhibit antiviral activity against Hepatitis C in a study with 31 patients. This effect has been described as modest, variable, and often short-lived by the authors.[3]

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Neuvonen, PJ; Backman, JT; Niemi, M (2008). "Pharmacokinetic comparison of the potential over-the-counter statins simvastatin, lovastatin, fluvastatin and pravastatin.". Clinical Pharmacokinetics 47 (7): 463–74. doi:10.2165/00003088-200847070-00003. PMID 18563955.
  2. ↑ 2.0 2.1 "Lescol, Lescol XR (fluvastatin) dosing, indications, interactions, adverse efects, and more". Medscape Reference. WebMD. Retrieved 18 March 2014.
  3. ↑ Bader T, Fazili J, Madhoun M et al. (April 2008). "Fluvastatin Inhibits Hepatitis C Replication in Humans". Am. J. Gastroenterol. 103 (6): 1383–9. doi:10.1111/j.1572-0241.2008.01876.x. PMID 18410471.