Flumedroxone

Flumedroxone
Systematic (IUPAC) name


(2R,8S,14S,15S)-14-acetyl-14-hydroxy-2,15-dimethyl-8-(trifluoromethyl)tetracyclo[8.7.0.0^2,7.0^11,15]heptadec-6-en-5-one
Clinical data
Identifiers
CAS Registry Number	987-18-8
ATC code	N02CB01
PubChem	CID 71881
ChemSpider	16736667
UNII	K80185F39X^Y
ChEMBL	CHEMBL2104932
Synonyms	(6S,10R,13S,17S)-17-acetyl-17-hydroxy-10,13-dimethyl-6-(trifluoromethyl)-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one 17-Acetyloxy-6α-(trifluoromethyl)preg-4-ene-3,20-dione
Chemical data
Formula	C₂₂H₂₉F₃O₃
Molecular mass	398.459 g/mol
SMILES CC(=O)[C@]1(CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2C[C@@H](C4=CC(=O)CC[C@]34C)C(F)(F)F)C)O
InChI InChI=1S/C22H29F3O3/c1-12(26)21(28)9-6-16-14-11-18(22(23,24)25)17-10-13(27)4-7-19(17,2)15(14)5-8-20(16,21)3/h10,14-16,18,28H,4-9,11H2,1-3H3/t14-,15+,16+,18+,19-,20+,21+/m1/s1 Key:CDZJOBWKHSYNMO-SCUQKFFVSA-N
Y (what is this?) (verify)

Flumedroxone is a corticosteroid derivative used to treat migraines. In one study, the benefit was largely limited to women with headache associated with premenstrual syndrome.^[1]

References

↑ Bradley WG, Hudgson P, Foster JB, Newell DJ (August 1968). "Double-blind controlled trial of a micronized preparation of flumedroxone (Demigran) in prophylaxis of migraine". Br Med J 3 (5617): 531–3. doi:10.1136/bmj.3.5617.531. PMC 1986487. PMID 4877801.

Antimigraine preparations (N02C)

Analgesic/abortive

Ergolines	Dihydroergotamine Ergotamine Methysergide Lisuride

5-HT₁ agonists	Triptans Almotriptan Avitriptan Eletriptan Frovatriptan Naratriptan Rizatriptan Sumatriptan Zolmitriptan Alniditan

Others	Dimetotiazine Dotarizine Iprazochrome Oxetorone Pizotifen

Others

Paracetamol^#
Amidrine

Calcium channel blockers	Dotarizine Lomerizine Verapamil

Corticosteroids	Flumedroxone

Sympatholytics	Beta blockers Propranolol^# Timolol Clonidine

Tricyclic antidepressants	Amitriptyline Nortriptyline Imipramine

Anticonvulsants	Carbamazepine Oxcarbazepine Topiramate Valproate

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

Index of the central nervous system

Description	Anatomy meninges cortex association fibers commissural fibers lateral ventricles basal ganglia diencephalon mesencephalon pons cerebellum medulla spinal cord tracts Physiology neutrotransmission enzymes intermediates Development

Disease	Cerebral palsy Meningitis Demyelinating diseases Seizures and epilepsy Headache Stroke Sleep Congenital Injury Neoplasms and cancer Other paralytic syndromes ALS Symptoms and signs head and neck eponymous lesions Tests CSF

Treatment	Procedures Drugs general anesthetics analgesics addiction epilepsy cholinergics migraine Parkinson's vertigo other