Fluanisone

Fluanisone
Systematic (IUPAC) name

1-(4-fluorophenyl)-4-[4-(2-methoxyphenyl)piperazin-1-yl]butan-1-one
Clinical data
Identifiers
ATC code	N05AD09
PubChem	CID 15139
ChemSpider	14410^Y
UNII	1D0W98U1I4^Y
KEGG	D02621^Y
ChEMBL	CHEMBL58792^Y
Chemical data
Formula	C₂₁H₂₅F N₂O₂
Molecular mass	356.43 g/mol
SMILES Fc1ccc(cc1)C(=O)CCCN3CCN(c2ccccc2OC)CC3
InChI InChI=1S/C21H25FN2O2/c1-26-21-7-3-2-5-19(21)24-15-13-23(14-16-24)12-4-6-20(25)17-8-10-18(22)11-9-17/h2-3,5,7-11H,4,6,12-16H2,1H3 ^Y Key:IRYFCWPNDIUQOW-UHFFFAOYSA-N ^Y
Y (what is this?) (verify)

Fluanisone is a typical antipsychotic and sedative of the butyrophenone chemical class. It is used in the treatment of schizophrenia and mania.

References

Antipsychotics (neuroleptics) (N05A)

Typical

Benzamides: Levosulpiride; Nemonapride; Sulpiride; Sultopride; Tiapride; Veralipride

Butyrophenones: Azaperone; Benperidol; Bromperidol; Droperidol; Fluanisone; Haloperidol #; Lenperone; Moperone; Pipamperone; Spiperone; Timiperone; Trifluperidol

Diphenylbutylpiperidines: Clopimozide; Fluspirilene; Penfluridol; Pimozide

Phenothiazines: Acepromazine; Acetophenazine; Butaperazine; Carphenazine; Chloracizine; Chlorproethazine; Chlorpromazine; Cyamemazine; Dixyrazine; Fluacizine; Fluphenazine; Levomepromazine/Methotrimeprazine; Mesoridazine; Perazine; Periciazine; Perphenazine; Piperacetazine; Pipotiazine; Prochlorperazine; Promazine; Promethazine; Propiomazine; Sulforidazine; Thiethylperazine; Thiopropazate; Thioproperazine; Thioridazine; Trifluoperazine; Triflupromazine

Thioxanthenes: Chlorprothixene; Clopenthixol; Flupentixol; Thiothixene; Zuclopenthixol

Tricyclics: Butaclamol; Fluotracen; Loxapine; Trimipramine

Others: Prothipendyl

Atypical

Benzamides: Amisulpride; Remoxipride‡

Butyrophenones: Cinuperone; Melperone; Setoperone

Benzo(iso)oxazole piperidines: Iloperidone; Ocaperidone; Paliperidone; Risperidone #

Benzo(iso)thiazole piperazines: Lurasidone; Perospirone; Revospirone; Tiospirone; Ziprasidone

Diphenylbutylpiperazines: Amperozide

Phenylpiperazines: Aripiprazole; Bifeprunox; Brexpiprazole^†

Tricyclics: Amoxapine; Asenapine; Carpipramine; Clocapramine; Clorotepine; Clotiapine; Clozapine #; Fluperlapine; Metitepine; Mosapramine; Olanzapine; Quetiapine; Tenilapine; Zotepine

Others: Blonanserin; Cariprazine; Molindone; Pimavanserin; Sertindole; Zicronapine^†

Others

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

Index of psychology and psychiatry

Description	Mental processes

Disorders	Mental and behavioral ADHD OCD Tourette's Mood Developmental pervasive dyslexia and specific Substance-related alcohol Emotional and behavioral Symptoms and signs eponymous Evaluation and testing

Treatment	Psychotherapy CBT Drugs depression antipsychotics anxiety dementia hypnotics and sedatives psychostimulants, ADHD and nootropics

Cholinergics

Receptor ligands

mACh	Agonists: 77-LH-28-1 AC-42 AC-260,584 Aceclidine Acetylcholine AF30 AF150(S) AF267B AFDX-384 Alvameline AQRA-741 Arecoline Bethanechol Butyrylcholine Carbachol CDD-0034 CDD-0078 CDD-0097 CDD-0098 CDD-0102 Cevimeline Choline cis-Dioxolane Ethoxysebacylcholine Itameline LY-593,039 L-689,660 LY-2,033,298 McNA343 Methacholine Milameline Muscarine NGX-267 Ocvimeline Oxotremorine PD-151,832 Pilocarpine RS86 Sabcomeline SDZ 210-086 Sebacylcholine Suberyldicholine Talsaclidine Tazomeline Thiopilocarpine Vedaclidine VU-0029767 VU-0090157 VU-0152099 VU-0152100 VU-0238429 WAY-132,983 Xanomeline YM-796 Antagonists: 3-Quinuclidinyl benzilate 4-DAMP Aclidinium bromide Anisodamine Anisodine Antihistamines (first-generation) (e.g., brompheniramine, chlorphenamine, cyproheptadine, dimenhydrinate, diphenhydramine, doxylamine, mepyramine (pyrilamine), phenindamine, pheniramine, promethazine, tripelennamine, triprolidine) Atropine Atropine methonitrate Atypical antipsychotics (e.g., clozapine, olanzapine, quetiapine, zotepine) Benactyzine Benzatropine (benztropine) Benzydamine BIBN 99 Biperiden Bornaprine CAR-226,086 CAR-301,060 CAR-302,196 CAR-302,282 CAR-302,368 CAR-302,537 CAR-302,668 CS-27349 Cyclobenzaprine Cyclopentolate Darifenacin DAU-5884 Dimethindene Dexetimide DIBD Dicyclomine (dicycloverine) Ditran EA-3167 EA-3443 EA-3580 EA-3834 Etanautine Etybenzatropine (ethybenztropine) Flavoxate Himbacine HL-031,120 Ipratropium bromide J-104,129 Hyoscyamine Mamba toxin 3 Mamba toxin 7 Mazaticol Mebeverine Methoctramine Metixene N-Ethyl-3-piperidyl benzilate N-Methyl-3-piperidyl benzilate Orphenadrine Otenzepad Oxybutynin PBID PD-102,807 PD-0298029 Phenglutarimide Phenyltoloxamine Pirenzepine Piroheptine Procyclidine Profenamine RU-47,213 SCH-57,790 SCH-72,788 SCH-217,443 Scopolamine (hyoscine) Solifenacin Telenzepine Tetracyclic antidepressants (e.g., amoxapine, maprotiline, mianserin, mirtazapine) Tiotropium bromide Tolterodine Tricyclic antidepressants (e.g., amitriptyline, butriptyline, clomipramine, desipramine, dosulepin (dothiepin), doxepin, imipramine, lofepramine, nortriptyline, protriptyline, trimipramine) Trihexyphenidyl Tripitamine Tropatepine Tropicamide Typical antipsychotics (e.g., chlorpromazine, loxapine, thioridazine) WIN-2299 Xanomeline Zamifenacin

nACh	Agonists: 5-HIAA A-84,543 A-366,833 A-582,941 A-867,744 ABT-202 ABT-418 ABT-560 ABT-894 Acetylcholine Altinicline Anabasine Anatoxin-a AR-R17779 Butinoline Butyrylcholine Carbachol Choline Cotinine Cytisine Decamethonium Desformylflustrabromine Dianicline Dimethylphenylpiperazinium Epibatidine Epiboxidine Ethanol Ethoxysebacylcholine EVP-4473 EVP-6124 Galantamine GTS-21 Ispronicline Ivermectin Levamisole Lobeline MEM-63,908 (RG-3487) Morantel Nicotine (tobacco) NS-1738 PHA-543,613 PHA-709,829 PNU-120,596 PNU-282,987 Pozanicline Rivanicline RJR-2429 Sazetidine A SB-206553 Sebacylcholine SIB-1508Y SIB-1553A SSR-180,711 Suberyldicholine Suxamethonium (succinylcholine) TC-1698 TC-1734 TC-1827 TC-2216 TC-5214 TC-5619 TC-6683 Tebanicline Tropisetron UB-165 Varenicline WAY-317,538 XY-4083 Antagonists: 18-MAC 18-MC α-Bungarotoxin α-Conotoxin ABT-126 Alcuronium Allopregnanolone Amantadine Anatruxonium AQW051 Atracurium Barbiturates (e.g., pentobarbital, sodium thiopental) Bupropion Chandonium Chlorisondamine Cisatracurium Coclaurine Coronaridine Cyclopropane Dacuronium Decamethonium Desflurane Dextromethorphan Dextropropoxyphene Dextrorphan Diadonium DHβE Dihydrochandonium Dimethyltubocurarine (metocurine) Dipyrandium Dizocilpine (MK-801) Doxacurium Encenicline Enflurane Esketamine Fazadinium Gallamine Halothane Hexafluronium Hexamethonium (benzohexonium) Hydroxybupropion Ibogaine Isoflurane Ketamine Kynurenic acid Laudexium (laudolissin) Levacetylmethadol Levomethadone Malouetine ME-18-MC Mecamylamine Memantine Methadone Methorphan (racemethorphan) Methyllycaconitine Metocurine Mivacurium Morphanol (racemorphan) Neramexane Nitrous oxide Pancuronium bromide Pempidine Pentamine Pentolinium Phencyclidine Pipecuronium Progesterone Promegestone Radafaxine Rapacuronium Reboxetine Rocuronium Sevoflurane Surugatoxin Thiocolchicoside Toxiferine Tramadol Trimetaphan camsilate (trimethaphan camsylate) Tropeinium Tubocurarine Vanoxerine Vecuronium Xenon

Transporter ligands

CHT	Inhibitors: Hemicholinium-3 (hemicholine) Triethylcholine Enhancers: Coluracetam

VAChT	Inhibitors: Vesamicol

Enzyme inhibitors

ChAT	1-(-Benzoylethyl)pyridinium 2-(α-Naphthoyl)ethyltrimethylammonium 3-Chloro-4-stillbazole 4-(1-Naphthylvinyl)pyridine Acetylseco hemicholinium-3 Acryloylcholine AF64A B115 BETA CM-54,903 N,N-Dimethylaminoethylacrylate N,N-Dimethylaminoethylchloroacetate

AChE	Reversible: Carbamates: Aldicarb Bendiocarb Bufencarb Carbaryl Carbendazim Carbetamide Carbofuran Chlorbufam Chloropropham Ethienocarb Ethiofencarb Fenobucarb Fenoxycarb Formetanate Furadan Ladostigil Methiocarb Methomyl Miotine Oxamyl Phenmedipham Pinmicarb Pirimicarb Propamocarb Propham Propoxur; Stigmines: Distigmine bromide Eptastigmine Ganstigmine Neostigmine Phenserine Physostigmine Pyridostigmine bromide Quilostigmine Rivastigmine Terestigmine; Others: Acotiamide Ambenonium Donepezil Caffeine Edrophonium Galantamine Huperzine A Ipidacrine Minaprine Tacrine Zanapezil Irreversible: Organophosphates: Acephate Azinphos-methyl Bensulide Cadusafos Chlorethoxyfos Chlorfenvinphos Chlorpyrifos Chlorpyrifos-methyl Coumaphos Cyclosarin Demeton Demeton-S-methyl Diazinon Dichlorvos Dicrotophos Diisopropyl fluorophosphate Diisopropylphosphate Dimethoate Dioxathion Disulfoton EA-3148 Echothiophate Ethion Ethoprop Fenamiphos Fenitrothion Fenthion Fosthiazate GV Isofluorophate Isoxathion Malaoxon Malathion Methamidophos Methidathion Metrifonate Mevinphos Monocrotophos Naled Novichok agent Omethoate Oxydemeton-methyl Paraoxon Parathion Parathion-methyl Phorate Phosalone Phosmet Phoxim Pirimiphos-methyl Sarin Soman Tabun Tebupirimfos Temefos Terbufos Tetrachlorvinphos Tribufos Trichlorfon VE VG VM VR VX; Others: Demecarium Onchidal (Onchidella binneyi)

BChE	Cymserine Note: Many of the AChE inhibitors listed above also act as BChE inhibitors.

Others

Precursors	Choline (lecithin) Citicoline Cyprodenate Dimethylethanolamine Glycerophosphocholine Meclofenoxate (centrophenoxine) Phosphatidylcholine Phosphatidylethanolamine Phosphorylcholine Pirisudanol

Cofactors	Acetic acid Acetylcarnitine Acetyl-coA Vitamin B₅

Others	Acetylcholine releasing agents: α-Latrotoxin β-Bungarotoxin; Acetylcholine release inhibitors: Botulinum toxin (Botox); Acetylcholinesterase reactivators: Asoxime Obidoxime Pralidoxime

Index of the central nervous system

Description	Anatomy meninges cortex association fibers commissural fibers lateral ventricles basal ganglia diencephalon mesencephalon pons cerebellum medulla spinal cord tracts Physiology neutrotransmission enzymes intermediates Development

Disease	Cerebral palsy Meningitis Demyelinating diseases Seizures and epilepsy Headache Stroke Sleep Congenital Injury Neoplasms and cancer Other paralytic syndromes ALS Symptoms and signs head and neck eponymous lesions Tests CSF

Treatment	Procedures Drugs general anesthetics analgesics addiction epilepsy cholinergics migraine Parkinson's vertigo other

Dopaminergics

Receptor ligands

Agonists: Adamantanes: Amantadine
Memantine
Rimantadine; Aminotetralins: 7-OH-DPAT
8-OH-PBZI
Rotigotine
UH-232; Benzazepines: 6-Br-APB
Fenoldopam
SKF-38,393
SKF-77,434
SKF-81,297
SKF-82,958
SKF-83,959; Ergolines: Bromocriptine
Cabergoline
Dihydroergocryptine
Epicriptine
Lisuride
LSD
Pergolide; Dihydrexidine derivatives: 2-OH-NPA
A-86929
Adrogolide (ABT-431, DAS-431)
Ciladopa
Dihydrexidine
Dinapsoline
Dinoxyline
Doxanthrine; Others: A-68930
A-77636
A-412997
ABT-670
ABT-724
Aplindore
Apomorphine
Aripiprazole
Bifeprunox
BP-897
Captodiame
CY-208,243
Dizocilpine
Etilevodopa
Flibanserin
Ketamine
Melevodopa
Modafinil
Pardoprunox
Phencyclidine
PD-128,907
PD-168,077
PF-219,061
Piribedil
Pramipexole
Propylnorapomorphine
Pukateine
Quinagolide
Quinelorane
Quinpirole
RDS-127
Ro10-5824
Ropinirole
Rotigotine
Roxindole
Salvinorin A
SKF-89,145
Sumanirole
Terguride
Umespirone
WAY-100,635

Antagonists: Typical antipsychotics: Acepromazine
Azaperone
Benperidol
Bromperidol
Clopenthixol
Chlorpromazine
Chlorprothixene
Droperidol
Flupentixol
Fluphenazine
Fluspirilene
Haloperidol
Levosulpiride
Loxapine
Mesoridazine
Methotrimeprazine
Nemonapride
Penfluridol
Perazine
Periciazine
Perphenazine
Pimozide
Prochlorperazine
Promazine
Sulforidazine
Sulpiride
Sultopride
Thioridazine
Thiothixene
Trifluoperazine
Triflupromazine
Trifluperidol
Zuclopenthixol; Atypical antipsychotics: Amisulpride
Asenapine
Blonanserin
Cariprazine
Carpipramine
Clocapramine
Clorotepine
Clozapine
Gevotroline
Iloperidone
Lurasidone
Melperone
Molindone
Mosapramine
Olanzapine
Paliperidone
Perospirone
Piquindone
Quetiapine
Remoxipride
Risperidone
Sertindole
Tiospirone
Zicronapine
Ziprasidone
Zotepine; Antiemetics: AS-8112
Alizapride
Bromopride
Clebopride
Domperidone
Metoclopramide
Thiethylperazine; Others: Amoxapine
Buspirone
Butaclamol
Ecopipam
EEDQ
Eticlopride
Fananserin
Hydroxyzine
L-745,870
Nafadotride
Nuciferine
PNU-99,194
Raclopride
Sarizotan
SB-277,011-A
SCH-23,390
SKF-83,959
Sonepiprazole
Spiperone
Spiroxatrine
Stepholidine
Tetrahydropalmatine
Tiapride
UH-232
Yohimbine

NAMs: SB-269,652

Transporter modulators

DAT	Inhibitors: Piperazines: DBL-583 GBR-12783 GBR-12935 GBR-13069 GBR-13098 Nefazodone Vanoxerine; Piperidines: 3,4-Dichloropethidine 4-Fluoropethidine 4-Iodopethidine Benocyclidine (BTCP) Desoxypipradrol Dextromethylphenidate Difemetorex Ethylphenidate Methylnaphthidate Methylphenidate Pethidine (meperidine) Phencyclidine Pipradrol; Pyrrolidines: Diphenylprolinol MDPV Naphyrone Prolintane Pyrovalerone; Tropanes: 3-CPMT) 3α-Bis-(4-fluorophenyl)methoxytropane AHN-1055 AHN-2005 Altropane Benzatropine (benztropine) Brasofensine CFT Cocaine Dichloropane Difluoropine Etybenzatropine (ethybenztropine) FE-β-CPPIT FP-β-CPPIT Ioflupane (¹²³I) Iometopane JHW-007 RTI-112 RTI-113 RTI-121 RTI-126 RTI-150 RTI-177 RTI-229 RTI-336 Tenocyclidine Tesofensine Troparil Tropoxane WF-11 WF-23 WF-31 WF-33; Others: (S)-Duloxetine Adrafinil Armodafinil Amfonelic acid Amineptine Bromantane BTQ BTS-74,398 Bupropion Chaenomeles speciosa Ciclazindol Dasotraline Desmethylsertraline Diclofensine Dimethocaine Diphenylpyraline Dizocilpine (MK-801) DOV-102677 DOV-21947 DOV-216303 Efavirenz EXP-561 Fencamfamine Fezolamine Fluorenol GYKI-52,895 Indatraline Ketamine Lefetamine Levophacetoperane Liafensine LR-5182 Manifaxine Mazindol Medifoxamine Mesocarb Metaphit Modafinil Nefopam Nomifensine NS-2359 O-2172 Oroxylin A Perafensine Pridefrine Radafaxine Rimcazole SEP-228431 SEP-228432 Sertraline Sibutramine Tametraline Tedatioxetine Tripelennamine Venlafaxine Enhancers: Luteolin Modulators: Agonist-like: SoRI-9804 SoRI-20040; Antagonist-like: SoRI-20041

VMATs	Inhibitors: Amiodarone Amphetamines (e.g., amphetamine, methamphetamine, MDMA) APP AZIK Bietaserpine Deserpidine Dihydrotetrabenazine Efavirenz GBR-12935 GZ-793A Ibogaine Ketanserin Lobeline Methoxytetrabenazine NBI-98854 Reserpine Rose bengal SD-809 Tetrabenazine Vanoxerine (GBR-12909)

Releasing agents

Morpholines: Fenbutrazate
Fenmetramide
Morazone
Morforex
Phendimetrazine
Phenmetrazine
Pseudophenmetrazine; Oxazolines: 4-MAR
Aminorex
Clominorex
Cyclazodone
Fenozolone
Fluminorex
Pemoline
Thozalinone; Phenethylamines (also amphetamines, cathinones, etc): 2-OH-PEA
4-CAB
4-FA
4-FMA
4-MA
4-MMA
Alfetamine
Amfecloral
Amfepentorex
Amfepramone
Amphetamine (Dextroamphetamine
Levoamphetamine)
Amphetaminil
β-Me-PEA
BDB
BOH
Benzphetamine
Buphedrone
Bupropion
Butylone
Cathine
Cathinone
Clobenzorex
Clortermine
D-Deprenyl
DMA
DMMA
Dimethylamphetamine
Dimethylcathinone
Ephedrine
Ethcathinone
EBDB
Ethylone
Etilamfetamine
Famprofazone
Fenethylline
Fenproporex
Flephedrone
Fludorex
Furfenorex
Hordenine
4-Hydroxyamphetamine
Iofetamine
Lophophine
Mefenorex
Mephedrone
Methamphetamine (Dextromethamphetamine, Levomethamphetamine)
Methcathinone
Methedrone
MMDA
MMDMA
MBDB
MDA
MDEA
MDMA
MDMPEA
MDOH
MDPEA
Methylone
Morforex
Ortetamine
pBA
pCA
pIA
Pholedrine
Phenethylamine
Pholedrine
Phenpromethamine
Prenylamine
Propylamphetamine
Pseudoephedrine
Tiflorex
Tyramine
Xylopropamine
Zylofuramine; Piperazines: 2C-B-BZP
BZP
MBZP
MDBZP
MeOPP; Others: 2-ADN
2-AI
2-AT
4-BP
5-IAI
Clofenciclan
Cyclopentamine
Cypenamine
Cyprodenate
Feprosidnine
Gilutensin
Heptaminol
Hexacyclonate
IAP
Indanorex
Isometheptene
Methylhexanamine
Naphthylisopropylamine
Octodrine
Phthalimidopropiophenone
Propylhexedrine (Levopropylhexedrine)
Tuaminoheptane

Enzyme inhibitors

PAH	3,4-Dihydroxystyrene

TH	3-Iodotyrosine Aquayamycin Bulbocapnine Metirosine Oudenone

AAAD	Benserazide Carbidopa DFMD Genistein Methyldopa

MAO	Nonselective: Benmoxin Caroxazone Echinopsidine Furazolidone Hydralazine Indantadol Iproclozide Iproniazid Isocarboxazid Isoniazid Linezolid Mebanazine Metfendrazine Nialamide Octamoxin Paraxazone Phenelzine Pheniprazine Phenoxypropazine Pivalylbenzhydrazine Procarbazine Safrazine Tranylcypromine; MAO-A selective: Amiflamine Bazinaprine Befloxatone Brofaromine Cimoxatone Clorgiline Eprobemide Esuprone Harmala alkaloids Methylene Blue Metralindole Minaprine Moclobemide Pirlindole Sercloremine Tetrindole Toloxatone Tyrima; MAO-B selective: D-Deprenyl Ethanol Ladostigil Lazabemide Milacemide Nicotine Pargyline^‡ Rasagiline Safinamide Selegiline (L-deprenyl)

COMT	Entacapone Nitecapone Opicapone Tolcapone

DBH	Disulfiram Dopastin Fusaric acid Nepicastat Tropolone

Others

Precursors	L-Phenylalanine → L-Tyrosine → L-DOPA (levodopa)

Cofactors	Ferrous iron (Fe²⁺) Tetrahydrobiopterin Vitamin B₃ (Niacin Nicotinamide → NADPH) Vitamin B₆ (Pyridoxine Pyridoxamine Pyridoxal → Pyridoxal phosphate) Vitamin B₉ (Folic acid → Tetrahydrofolic acid) Vitamin C (Ascorbic acid) Zinc (Zn²⁺)

Neurotoxins	Amphetamine DMDHIQ⁺ Methamphetamine MPP⁺ MPTP NMDHIQ⁺ NMNorsal (2-MDTIQ) NMSal Norsalsolinol Oxidopamine (6-OHDA) Rotenone Salsolinol

Others	Activity enhancers: BPAP PPAP; Levodopa prodrugs: XP21279

See also: Adrenergics • Melatonergics • Serotonergics • List of dopaminergic drugs

Histaminergics

Receptor
(ligands)

H₁	Agonists: 2-Pyridylethylamine Betahistine Histamine HTMT UR-AK49 Antagonists: First-generation: 4-Methyldiphenhydramine Alimemazine Antazoline Azatadine Bamipine Benzatropine (benztropine) Bepotastine Bromazine Brompheniramine Buclizine Captodiame Carbinoxamine Chlorcyclizine Chloropyramine Chlorothen Chlorphenamine Chlorphenoxamine Cinnarizine Clemastine Clobenzepam Clocinizine Cyclizine Cyproheptadine Dacemazine Decloxizine Deptropine Dexbrompheniramine Dexchlorpheniramine Dimenhydrinate Dimetindene Diphenhydramine Diphenylpyraline Doxylamine Embramine Etodroxizine Etybenzatropine (ethylbenztropine) Etymemazine Flunarizine Histapyrrodine Homochlorcyclizine Hydroxyethylpromethazine Hydroxyzine Isopromethazine Isothipendyl Meclozine Medrylamine Mepyramine (pyrilamine) Mequitazine Methafurylene Methapyrilene Methdilazine Moxastine Orphenadrine Oxatomide Oxomemazine Phenindamine Pheniramine Phenyltoloxamine Pimethixene Piperoxan Pipoxizine Promethazine Propiomazine Pyrrobutamine Talastine Thenalidine Thenyldiamine Thiazinamium Thonzylamine Tolpropamine Tripelennamine Triprolidine Second/third-generation: Acrivastine Alinastine Astemizole Azelastine Bamirastine Barmastine Bepiastine Bepotastine Bilastine Cabastinen Carebastine Cetirizine Clemastine Clemizole Clobenztropine Desloratadine Dorastine Ebastine Efletirizine Emedastine Epinastine Fexofenadine Flezelastine Ketotifen Latrepirdine Levocabastine Levocetirizine Linetastine Loratadine Mapinastine Mebhydrolin Mizolastine Moxastine Noberastine Octastine Olopatadine Perastine Pibaxizine Piclopastine Rocastine Rupatadine Setastine Talastine Temelastine Terfenadine Vapitadine Zepastine Non-generational: Atypical antipsychotics (e.g., aripiprazole, asenapine, clozapine, iloperidone, olanzapine, paliperidone, quetiapine, risperidone, ziprasidone, zotepine) Tetracyclic antidepressants (e.g., amoxapine, loxapine, maprotiline, mianserin, mirtazapine, oxaprotiline) Tricyclic antidepressants (e.g., amitriptyline, butriptyline, clomipramine, desipramine, dosulepin (dothiepin), doxepin, imipramine, iprindole, lofepramine, nortriptyline, protriptyline, trimipramine) Typical antipsychotics (e.g., chlorpromazine, flupenthixol, fluphenazine, loxapine, perphenazine, prochlorperazine, thioridazine, thiothixene) Unknown/unsorted: Belarizine Elbanizine Flotrenizine Napactadine Tagorizine Trelnarizine Trenizine

H₂	Agonists: Amthamine Betazole Dimaprit Histamine HTMT Impromidine UR-AK49 Antagonists: Bisfentidine Burimamide Cimetidine Dalcotidine Donetidine Ebrotidine Etintidine Famotidine Lafutidine Lamtidine Lavoltidine (loxtidine) Lupitidine Metiamide Mifentidine Niperotidine Nizatidine Osutidine Oxmetidine Pibutidine Quisultazine (quisultidine) Ramixotidine Ranitidine Roxatidine Sufotidine Tiotidine Tuvatidine Venritidine Xaltidine

H₃	Agonists: α-Methylhistamine Cipralisant Histamine Imetit Immepip Immethridine Methimepip Proxyfan Antagonists: A-349,821 A-423,579 ABT-239 ABT-652 AZD5213 Betahistine Burimamide Ciproxifan Clobenpropit Conessine GSK-189,254 Impentamine Iodophenpropit Irdabisant JNJ-5207852 MK-0249 NNC 38-1049 PF-03654746 Pitolisant SCH-79687 Thioperamide VUF-5681

H₄	Agonists: 4-Methylhistamine α-Methylhistamine Histamine VUF-8430 Antagonists: JNJ-7777120 JNJ-38518168 Mianserin Thioperamide VUF-6002

Transporter
(inhibitors)

VMATs

TAAR1 inactive	Amiodarone APP AZIK Bietaserpine Deserpidine Dihydrotetrabenazine Efavirenz GBR-12935 GZ-793A Ibogaine Ketanserin Lobeline Methoxytetrabenazine NBI-98854 Reserpine Rose bengal SD-809 Tetrabenazine Vanoxerine (GBR-12909)

TAAR1 active	Amphetamine Methamphetamine MDMA Phenethylamine

Enzyme
(inhibitors)

HDC	Catechin Meciadanol Naringenin Tritoqualine

HNMT	Amodiaquine Diphenhydramine Harmaline Metoprine Quinacrine SKF-91,488 Tacrine

DAO	Aminoguanidine

Others

Precursors	L -Histidine

Cofactors	Vitamin B₆

Index of the respiratory system

Description	Anatomy nose larynx lower thorax Physiology Development

Disease	Congenital Neoplasms and cancer Chest trauma Infection common cold pneumonia tuberculosis Other Symptoms and signs eponymous

Treatment	Procedures mechanical ventilation Drugs nasal throat obstructive airway diseases cough and cold histaminergics pulmonary arterial hypertension other Surgery