Flavokavain B

Flavokavain B
Names
IUPAC name
(E)-1-(2-Hydroxy-4,6-dimethoxy-phenyl)-3-phenyl-propenone
Other names
2'-hydroxy-4',6'-dimethoxychalcone
Flavokawain B
Identifiers
2059845
1775-97-9 Yes
Jmol-3D images Image
PubChem 5356121
Properties
Molecular formula
 C17H16O4
Molar mass 284.31 g·mol−1
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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Infobox references

Flavokavain B is a flavokavain found in the kava plant.[1] In 2010 a paper was published identifying it as a hepatotoxin.[2] Another paper published in 2013 suggests that Flavokavain B might be effective in killing bone cancer cells by pointing out evidence of apoptosis and cell cycle arrest by Flacokavain B treatment with less toxicity than the standard treatments.[3] Flavokavain B has been demonstrated to possess potent apoptotic abilities.[4]

See also

References

  1. ↑ Dharmaratne, H. Ranjith W.; N. P. Dhammika Nanayakkara; Ikhlas A. Khan (February 2002). "Kavalactones from Piper methysticum, and their 13C NMR spectroscopic analyses". Phytochemistry 59 (4): 429–33. doi:10.1016/S0031-9422(01)00443-5. PMID 11830162.
  2. ↑ Zhou P., Gross S., Liu J.-H., Yu B.-Y., Feng L.-L., Nolta J., Sharma V., Piwnica-Worms D., Qiu S.X 'Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-κB and MAPK signaling pathways . FASEB Journal 2010 24:12 (4722-4732)
  3. ↑ "Flavokawain B, a kava chalcone, inhibits growth of human osteosarcoma cells through G2/M cell cycle arrest and apoptosis". Molecular Cancer 12: 55. 2013. doi:10.1186/1476-4598-12-55. PMC 3681603. PMID 23764122.
  4. ↑ Ramez N. Eskander1, Leslie M. Randall1, Toshinori Sakai, Yi Guy, Bang Hoang, Xiaolin Zi. "Flavokawain B, a novel, naturally occurring chalcone, exhibits robust apoptotic effects and induces G2/M arrest of a uterine leiomyosarcoma cell line".

External links