Ferric uptake regulator family
| FUR | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 ferric uptake regulator | |||||||||
| Identifiers | |||||||||
| Symbol | FUR | ||||||||
| Pfam | PF01475 | ||||||||
| Pfam clan | CL0123 | ||||||||
| InterPro | IPR002481 | ||||||||
| SCOP | 1mzb | ||||||||
| SUPERFAMILY | 1mzb | ||||||||
| |||||||||
| Ferric Uptake Regulator (E. Coli) | |
|---|---|
|
ferric uptake regulator | |
| Identifiers | |
| Symbol | FUR |
| UniProt | P0A9A9 |
In molecular biology, the ferric uptake regulator (FUR) family of proteins includes metal ion uptake regulator proteins. These are responsible for controlling the intracellular concentration of iron in many bacteria. Although iron is essential for most organisms, high concentrations can be toxic because of the formation of hydroxyl radicals.[1] FURs can also control zinc homeostasis and is the subject of research on the pathogenesis of mycobacteria.[2]
References
- ↑ Pohl E, Haller JC, Mijovilovich A, Meyer-Klaucke W, Garman E, Vasil ML (February 2003). "Architecture of a protein central to iron homeostasis: crystal structure and spectroscopic analysis of the ferric uptake regulator". Mol. Microbiol. 47 (4): 903–15. doi:10.1046/j.1365-2958.2003.03337.x. PMID 12581348.
- ↑ Jiang H, Gao X, Li Y, Xu ZK, Wang LM, Bai XF, Yue Y (May 2008). "Prokaryotic expression and monoclonal antibody preparation of Mycobacterium tuberculosis ferric uptake regulator B". APMIS 116 (5): 372–81. doi:10.1111/j.1600-0463.2008.00975.x. PMID 18452427.
This article incorporates text from the public domain Pfam and InterPro IPR002481