Fenbendazole
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| Systematic (IUPAC) name | |
|---|---|
|
methyl N-(6-phenylsulfanyl-1H-benzoimidazol- 2-yl)carbamate | |
| Clinical data | |
| AHFS/Drugs.com | International Drug Names |
| Identifiers | |
43210-67-9  | |
| P02CA06 QP52AC13 | |
| PubChem | CID 3334 |
| ChemSpider |
3217 |
| UNII |
621BVT9M36 |
| KEGG |
D04140 |
| ChEBI |
CHEBI:77092  |
| ChEMBL |
CHEMBL37161 |
| Chemical data | |
| Formula | C15H13N3O2S |
| 299.349 g/mol | |
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Fenbendazole (Hoechst brand names Panacur and Safe-Guard, Intervet Panacur and Panacur Rabbit) is a broad spectrum benzimidazole anthelmintic used against gastrointestinal parasites including: giardia, roundworms, hookworms, whipworms, the taenia species of tapeworms(It is effective against the Taenia species of tapeworm but not against the common tapeworm, Dipylidium caninum.), pinworms, aelurostrongylus, paragonimiasis, strongyles and strongyloides and can be administered to sheep, cattle, horses, fish, dogs, cats, rabbits and seals. Drug interactions may occur if using bromsalan flukicides such as dibromsalan and tribromsalan. Abortions in cattle and death in sheep have been reported after using these medications together.[1]
Toxicity
Despite being widely used as a dewormer in many species, toxicity has been reported. Birds (storks, pink pelicans, vultures, pigeons and doves) and reptiles (vipers, turtles and tortoises) have shown toxicity associated with bone marrow suppression, intestinal crypt cell necrosis and distal villi sloughing. Abortions in domestic ruminants have been associated with concurrent use of anti-trematode therapeutic agents.
Fenbendazole is poorly absorbed from the gastrointestinal tract in most species. The LD50 in laboratory animals exceeds 10 g/kg when administered orally.[1]
References
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