Fasoracetam
| |||
Names | |||
---|---|---|---|
IUPAC name
(5R)-5-(piperidine-1-carbonyl) pyrrolidin-2-one | |||
Identifiers | |||
110958-19-5 ![]() | |||
ChemSpider | 171980 ![]() | ||
| |||
Jmol-3D images | Image Image | ||
KEGG | C13311 ![]() | ||
PubChem | 198695 | ||
| |||
Properties | |||
Molecular formula |
C10H16N2O2 | ||
Molar mass | 196.25 g·mol−1 | ||
Pharmacology | |||
Oral | |||
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa) | |||
![]() ![]() ![]() | |||
Infobox references | |||
Fasoracetam (NS-105, 5-oxo-D-prolinepiperidinamide monohydrate) is a research chemical of the racetam family.[1]
Effects
Fasoracetam appears to act as a GABAB receptor antagonist. It has been shown to block memory disruptions caused by Baclofen, a GABA B agonist.[2] Fasoracetam upregulates GABA B receptors after repeat dosing.[3]
Fasoracetam may act as a mGluR agonist and research into the efficacy for treating ADHD and cognitive impairment is currently being conducted.[4] [5]
Similar to Coluracetam, Fasoracetam enhances high affinity choline reuptake (HACU). [2]
References
- ↑ "5-oxo-D-prolinepiperidinamide monohydrate - Compound Summary". Retrieved 21 July 2013.
- ↑ 2.0 2.1 "Involvement of cholinergic and GABAergic systems in the reversal of memory disruption by NS-105, a cognition enhancer.".
- ↑ "Effect of a novel cognition enhancer NS-105 on learned helplessness in rats: possible involvement of GABA(B) receptor up-regulation after repeated treatment.".
- ↑ "A novel cognition enhancer NS-105 modulates adenylate cyclase activity through metabotropic glutamate receptors in primary neuronal culture.".
- ↑ http://www.research.chop.edu/forms/btob/Oct12BtoB.pdf